aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

Presenilins are components of the γ-secretase protein complex that mediates intramembranous cleavage of βAPP and Notch proteins. A C. elegans genetic screen revealed two genes, aph-1 and pen-2, encoding multipass transmembrane proteins, that interact strongly with sel-12/presenilin and aph-2/nicastr...

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Veröffentlicht in:	Developmental cell 2002-07, Vol.3 (1), p.85-97
Hauptverfasser:	Francis, Ross, McGrath, Garth, Zhang, Jianhuan, Ruddy, David A., Sym, Mary, Apfeld, Javier, Nicoll, Monique, Maxwell, Mark, Hai, Bing, Ellis, Michael C., Parks, Annette L., Xu, Wei, Li, Jinhe, Gurney, Mark, Myers, Richard L., Himes, Carol S., Hiebsch, Ronald, Ruble, Cara, Nye, Jeffrey S., Curtis, Daniel
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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