Branched-chain fatty acid composition of human milk and the impact of maternal diet: the Global Exploration of Human Milk (GEHM) Study
An understudied component of the diet, branched-chain fatty acids (BCFAs) are distinctive saturated fatty acids that may have an important influence on health. Human-milk fatty acid composition is known to differ worldwide, but comparative data are lacking on BCFAs. We tested the hypotheses that con...
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| Veröffentlicht in: | The American journal of clinical nutrition 2017-01, Vol.105 (1), p.177-184 |
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| creator | Dingess, Kelly A Valentine, Christina J Ollberding, Nicholas J Davidson, Barbara S Woo, Jessica G Summer, Suzanne Peng, Yongmei M Guerrero, M Lourdes Ruiz-Palacios, Guillermo M Ran-Ressler, Rinat R McMahon, Robert J Brenna, J Thomas Morrow, Ardythe L |
| description | An understudied component of the diet, branched-chain fatty acids (BCFAs) are distinctive saturated fatty acids that may have an important influence on health. Human-milk fatty acid composition is known to differ worldwide, but comparative data are lacking on BCFAs.
We tested the hypotheses that concentrations of BCFAs in human milk differ between populations and are associated with maternal diet.
We surveyed the BCFA composition of samples collected as part of a standardized, prospective study of human-milk composition. Mothers were enrolled from 3 urban populations with differing diets: Cincinnati, Ohio; Shanghai, China; and Mexico City, Mexico. Enrollment was limited to healthy mothers of term singleton infants. We undertook a cross-sectional analysis of milk from all women with samples at postpartum week 4 (n = 359; ∼120 women/site). Fatty acids were extracted from milk by using a modified Bligh-Dyer technique and analyzed by gas chromatography. Statistical analysis was performed by ANOVA and Tobit regression. For Cincinnati mothers, 24-h diet recalls were analyzed in relation to the individual BCFA concentrations measured in milk samples.
Total BCFAs in milk differed by site, with the highest concentration in Cincinnati followed by Mexico City and Shanghai (mean ± SE: 7.90 ± 0.41, 6.10 ± 0.36, and 4.27 ± 0.25 mg/100 mL, respectively; P < 0.001). Site differences persisted after delivery mode, maternal age, and body mass index were controlled for. The individual concentrations of iso-14:0, iso-16:0, iso-18:0, anteiso-15:0, and anteiso-17:0 also differed between sites. Milk concentrations of iso-14:0 and anteiso-15:0 were associated with maternal intake of dairy; iso-16:0 was associated with maternal intakes of dairy and beef.
BCFA concentrations in milk at 4 wk postpartum differed between mothers from Cincinnati, Shanghai, and Mexico City. Variations in human-milk BCFAs are influenced by diet. The impact of BCFAs on infant health warrants investigation. |
| doi_str_mv | 10.3945/ajcn.116.132464 |
| format | Article |
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We tested the hypotheses that concentrations of BCFAs in human milk differ between populations and are associated with maternal diet.
We surveyed the BCFA composition of samples collected as part of a standardized, prospective study of human-milk composition. Mothers were enrolled from 3 urban populations with differing diets: Cincinnati, Ohio; Shanghai, China; and Mexico City, Mexico. Enrollment was limited to healthy mothers of term singleton infants. We undertook a cross-sectional analysis of milk from all women with samples at postpartum week 4 (n = 359; ∼120 women/site). Fatty acids were extracted from milk by using a modified Bligh-Dyer technique and analyzed by gas chromatography. Statistical analysis was performed by ANOVA and Tobit regression. For Cincinnati mothers, 24-h diet recalls were analyzed in relation to the individual BCFA concentrations measured in milk samples.
Total BCFAs in milk differed by site, with the highest concentration in Cincinnati followed by Mexico City and Shanghai (mean ± SE: 7.90 ± 0.41, 6.10 ± 0.36, and 4.27 ± 0.25 mg/100 mL, respectively; P < 0.001). Site differences persisted after delivery mode, maternal age, and body mass index were controlled for. The individual concentrations of iso-14:0, iso-16:0, iso-18:0, anteiso-15:0, and anteiso-17:0 also differed between sites. Milk concentrations of iso-14:0 and anteiso-15:0 were associated with maternal intake of dairy; iso-16:0 was associated with maternal intakes of dairy and beef.
BCFA concentrations in milk at 4 wk postpartum differed between mothers from Cincinnati, Shanghai, and Mexico City. Variations in human-milk BCFAs are influenced by diet. The impact of BCFAs on infant health warrants investigation.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.3945/ajcn.116.132464</identifier><identifier>PMID: 27903517</identifier><language>eng</language><publisher>United States: American Society for Clinical Nutrition, Inc</publisher><subject>China ; Chromatography ; Cross-Sectional Studies ; Dairy Products ; Diet ; Fatty acids ; Fatty Acids - analysis ; Feeding Behavior ; Female ; Humans ; Infant, Newborn ; Lactation - metabolism ; Male ; Meat ; Mexico ; Milk ; Milk, Human - chemistry ; Mothers ; Ohio ; Pregnancy ; Prospective Studies ; Statistical analysis</subject><ispartof>The American journal of clinical nutrition, 2017-01, Vol.105 (1), p.177-184</ispartof><rights>2017 American Society for Nutrition.</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Jan 1, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-8d1b3058b454ff8c1ee8c462e5e1f652907f445e5c4ac0d6af138c5843ee98873</citedby><cites>FETCH-LOGICAL-c366t-8d1b3058b454ff8c1ee8c462e5e1f652907f445e5c4ac0d6af138c5843ee98873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27903517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dingess, Kelly A</creatorcontrib><creatorcontrib>Valentine, Christina J</creatorcontrib><creatorcontrib>Ollberding, Nicholas J</creatorcontrib><creatorcontrib>Davidson, Barbara S</creatorcontrib><creatorcontrib>Woo, Jessica G</creatorcontrib><creatorcontrib>Summer, Suzanne</creatorcontrib><creatorcontrib>Peng, Yongmei M</creatorcontrib><creatorcontrib>Guerrero, M Lourdes</creatorcontrib><creatorcontrib>Ruiz-Palacios, Guillermo M</creatorcontrib><creatorcontrib>Ran-Ressler, Rinat R</creatorcontrib><creatorcontrib>McMahon, Robert J</creatorcontrib><creatorcontrib>Brenna, J Thomas</creatorcontrib><creatorcontrib>Morrow, Ardythe L</creatorcontrib><title>Branched-chain fatty acid composition of human milk and the impact of maternal diet: the Global Exploration of Human Milk (GEHM) Study</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>An understudied component of the diet, branched-chain fatty acids (BCFAs) are distinctive saturated fatty acids that may have an important influence on health. Human-milk fatty acid composition is known to differ worldwide, but comparative data are lacking on BCFAs.
We tested the hypotheses that concentrations of BCFAs in human milk differ between populations and are associated with maternal diet.
We surveyed the BCFA composition of samples collected as part of a standardized, prospective study of human-milk composition. Mothers were enrolled from 3 urban populations with differing diets: Cincinnati, Ohio; Shanghai, China; and Mexico City, Mexico. Enrollment was limited to healthy mothers of term singleton infants. We undertook a cross-sectional analysis of milk from all women with samples at postpartum week 4 (n = 359; ∼120 women/site). Fatty acids were extracted from milk by using a modified Bligh-Dyer technique and analyzed by gas chromatography. Statistical analysis was performed by ANOVA and Tobit regression. For Cincinnati mothers, 24-h diet recalls were analyzed in relation to the individual BCFA concentrations measured in milk samples.
Total BCFAs in milk differed by site, with the highest concentration in Cincinnati followed by Mexico City and Shanghai (mean ± SE: 7.90 ± 0.41, 6.10 ± 0.36, and 4.27 ± 0.25 mg/100 mL, respectively; P < 0.001). Site differences persisted after delivery mode, maternal age, and body mass index were controlled for. The individual concentrations of iso-14:0, iso-16:0, iso-18:0, anteiso-15:0, and anteiso-17:0 also differed between sites. Milk concentrations of iso-14:0 and anteiso-15:0 were associated with maternal intake of dairy; iso-16:0 was associated with maternal intakes of dairy and beef.
BCFA concentrations in milk at 4 wk postpartum differed between mothers from Cincinnati, Shanghai, and Mexico City. Variations in human-milk BCFAs are influenced by diet. The impact of BCFAs on infant health warrants investigation.</description><subject>China</subject><subject>Chromatography</subject><subject>Cross-Sectional Studies</subject><subject>Dairy Products</subject><subject>Diet</subject><subject>Fatty acids</subject><subject>Fatty Acids - analysis</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Lactation - metabolism</subject><subject>Male</subject><subject>Meat</subject><subject>Mexico</subject><subject>Milk</subject><subject>Milk, Human - chemistry</subject><subject>Mothers</subject><subject>Ohio</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Statistical analysis</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc9P2zAUgK1paJSy826TpV3gkOLfcXYDVNpJIA7AOXKdZ9VdEmexI9F_YH_3Elo47PQkv8-f9PQh9I2SBS-EvDI72y4oVQvKmVDiE5rRguuMM5J_RjNCCMsKquQpOotxRwhlQqsv6JTlBeGS5jP096Y3rd1Cldmt8S12JqU9NtZX2IamC9EnH1ocHN4OjWlx4-vf2LQVTlvAvumMTdOyMQn61tS48pB-vi1XddiMD8vXrg69ebes3ywPk-VitVw_XOKnNFT7c3TiTB3h63HO0cvd8vl2nd0_rn7dXt9nliuVMl3RDSdSb4QUzmlLAbQVioEE6pRkBcmdEBKkFcaSShlHubZSCw5QaJ3zObo4eLs-_BkgprLx0UJdmxbCEEuqhWRSaUlG9Md_6C4M040TJWXBCWPFSF0dKNuHGHtwZdf7xvT7kpJySlROicoxUXlINP74fvQOmwaqD_69Cf8HLXKMIQ</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Dingess, Kelly A</creator><creator>Valentine, Christina J</creator><creator>Ollberding, Nicholas J</creator><creator>Davidson, Barbara S</creator><creator>Woo, Jessica G</creator><creator>Summer, Suzanne</creator><creator>Peng, Yongmei M</creator><creator>Guerrero, M Lourdes</creator><creator>Ruiz-Palacios, Guillermo M</creator><creator>Ran-Ressler, Rinat R</creator><creator>McMahon, Robert J</creator><creator>Brenna, J Thomas</creator><creator>Morrow, Ardythe L</creator><general>American Society for Clinical Nutrition, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>Branched-chain fatty acid composition of human milk and the impact of maternal diet: the Global Exploration of Human Milk (GEHM) Study</title><author>Dingess, Kelly A ; Valentine, Christina J ; Ollberding, Nicholas J ; Davidson, Barbara S ; Woo, Jessica G ; Summer, Suzanne ; Peng, Yongmei M ; Guerrero, M Lourdes ; Ruiz-Palacios, Guillermo M ; Ran-Ressler, Rinat R ; McMahon, Robert J ; Brenna, J Thomas ; Morrow, Ardythe L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-8d1b3058b454ff8c1ee8c462e5e1f652907f445e5c4ac0d6af138c5843ee98873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>China</topic><topic>Chromatography</topic><topic>Cross-Sectional Studies</topic><topic>Dairy Products</topic><topic>Diet</topic><topic>Fatty acids</topic><topic>Fatty Acids - analysis</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Lactation - metabolism</topic><topic>Male</topic><topic>Meat</topic><topic>Mexico</topic><topic>Milk</topic><topic>Milk, Human - chemistry</topic><topic>Mothers</topic><topic>Ohio</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dingess, Kelly A</creatorcontrib><creatorcontrib>Valentine, Christina J</creatorcontrib><creatorcontrib>Ollberding, Nicholas J</creatorcontrib><creatorcontrib>Davidson, Barbara S</creatorcontrib><creatorcontrib>Woo, Jessica G</creatorcontrib><creatorcontrib>Summer, Suzanne</creatorcontrib><creatorcontrib>Peng, Yongmei M</creatorcontrib><creatorcontrib>Guerrero, M Lourdes</creatorcontrib><creatorcontrib>Ruiz-Palacios, Guillermo M</creatorcontrib><creatorcontrib>Ran-Ressler, Rinat R</creatorcontrib><creatorcontrib>McMahon, Robert J</creatorcontrib><creatorcontrib>Brenna, J Thomas</creatorcontrib><creatorcontrib>Morrow, Ardythe L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dingess, Kelly A</au><au>Valentine, Christina J</au><au>Ollberding, Nicholas J</au><au>Davidson, Barbara S</au><au>Woo, Jessica G</au><au>Summer, Suzanne</au><au>Peng, Yongmei M</au><au>Guerrero, M Lourdes</au><au>Ruiz-Palacios, Guillermo M</au><au>Ran-Ressler, Rinat R</au><au>McMahon, Robert J</au><au>Brenna, J Thomas</au><au>Morrow, Ardythe L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Branched-chain fatty acid composition of human milk and the impact of maternal diet: the Global Exploration of Human Milk (GEHM) Study</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2017-01</date><risdate>2017</risdate><volume>105</volume><issue>1</issue><spage>177</spage><epage>184</epage><pages>177-184</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><abstract>An understudied component of the diet, branched-chain fatty acids (BCFAs) are distinctive saturated fatty acids that may have an important influence on health. Human-milk fatty acid composition is known to differ worldwide, but comparative data are lacking on BCFAs.
We tested the hypotheses that concentrations of BCFAs in human milk differ between populations and are associated with maternal diet.
We surveyed the BCFA composition of samples collected as part of a standardized, prospective study of human-milk composition. Mothers were enrolled from 3 urban populations with differing diets: Cincinnati, Ohio; Shanghai, China; and Mexico City, Mexico. Enrollment was limited to healthy mothers of term singleton infants. We undertook a cross-sectional analysis of milk from all women with samples at postpartum week 4 (n = 359; ∼120 women/site). Fatty acids were extracted from milk by using a modified Bligh-Dyer technique and analyzed by gas chromatography. Statistical analysis was performed by ANOVA and Tobit regression. For Cincinnati mothers, 24-h diet recalls were analyzed in relation to the individual BCFA concentrations measured in milk samples.
Total BCFAs in milk differed by site, with the highest concentration in Cincinnati followed by Mexico City and Shanghai (mean ± SE: 7.90 ± 0.41, 6.10 ± 0.36, and 4.27 ± 0.25 mg/100 mL, respectively; P < 0.001). Site differences persisted after delivery mode, maternal age, and body mass index were controlled for. The individual concentrations of iso-14:0, iso-16:0, iso-18:0, anteiso-15:0, and anteiso-17:0 also differed between sites. Milk concentrations of iso-14:0 and anteiso-15:0 were associated with maternal intake of dairy; iso-16:0 was associated with maternal intakes of dairy and beef.
BCFA concentrations in milk at 4 wk postpartum differed between mothers from Cincinnati, Shanghai, and Mexico City. Variations in human-milk BCFAs are influenced by diet. The impact of BCFAs on infant health warrants investigation.</abstract><cop>United States</cop><pub>American Society for Clinical Nutrition, Inc</pub><pmid>27903517</pmid><doi>10.3945/ajcn.116.132464</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | China Chromatography Cross-Sectional Studies Dairy Products Diet Fatty acids Fatty Acids - analysis Feeding Behavior Female Humans Infant, Newborn Lactation - metabolism Male Meat Mexico Milk Milk, Human - chemistry Mothers Ohio Pregnancy Prospective Studies Statistical analysis |
| title | Branched-chain fatty acid composition of human milk and the impact of maternal diet: the Global Exploration of Human Milk (GEHM) Study |
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