Thermohydrogel Containing Melanin for Photothermal Cancer Therapy
Melanin is an effective absorber of light and can extend to near infrared (NIR) regions. In this study, a natural melanin is presented as a photothermal therapeutic agent (PTA) because it provides a good photothermal conversion efficiency, shows biodegradability, and does not induce long‐term toxici...
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| Veröffentlicht in: | Macromolecular bioscience 2017-05, Vol.17 (5), p.n/a |
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| creator | Kim, Miri Kim, Hyun Soo Kim, Min Ah Ryu, Hyanghwa Jeong, Hwan‐Jeong Lee, Chang‐Moon |
| description | Melanin is an effective absorber of light and can extend to near infrared (NIR) regions. In this study, a natural melanin is presented as a photothermal therapeutic agent (PTA) because it provides a good photothermal conversion efficiency, shows biodegradability, and does not induce long‐term toxicity during retention in vivo. Poloxamer solution containing melanin (Pol–Mel) does not show any precipitation and shows sol–gel transition at body temperature. After irradiation from 808 nm NIR laser at 1.5 W cm−2 for 3 min, the photothermal conversion efficiency of Pol–Mel is enough to kill cancer cells in vitro and in vivo. The tumor growth of mice bearing CT26 tumors treated with Pol–Mel injection and laser irradiation is suppressed completely without recurrence postirradiation. All these results indicate that Pol–Mel can become an attractive PTA for photothermal cancer therapy.
Poloxamer solution containing melanin (Pol–Mel) shows sol–gel transition at body temperature after heat generation induced by near infrared 808 nm laser irradiation. Following intratumoral injection of Pol–Mel and the laser irradiation, the growth of the CT26 tumors is suppressed completely without recurrence. From these results, Pol–Mel is a potentially attractive photothermal therapeutic agent for cancer therapy. |
| doi_str_mv | 10.1002/mabi.201600371 |
| format | Article |
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Poloxamer solution containing melanin (Pol–Mel) shows sol–gel transition at body temperature after heat generation induced by near infrared 808 nm laser irradiation. Following intratumoral injection of Pol–Mel and the laser irradiation, the growth of the CT26 tumors is suppressed completely without recurrence. From these results, Pol–Mel is a potentially attractive photothermal therapeutic agent for cancer therapy.</description><identifier>ISSN: 1616-5187</identifier><identifier>EISSN: 1616-5195</identifier><identifier>DOI: 10.1002/mabi.201600371</identifier><identifier>PMID: 27906510</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Animals ; Biocompatibility ; Biodegradability ; Body temperature ; Cancer ; Cancer therapies ; cancer therapy ; Cell Line, Tumor ; Chemical compounds ; Chemical precipitation ; Humans ; Hydrogels - chemistry ; Hyperthermia, Induced - methods ; Infrared Rays ; Irradiation ; Male ; Melanin ; Melanins - administration & dosage ; Melanins - chemistry ; Melanins - therapeutic use ; Mice ; Mice, Inbred BALB C ; Neoplasms - therapy ; Pharmacology ; Phototherapy - methods ; Photothermal conversion ; photothermal therapy ; Poloxamer ; Sol-gel processes ; Temperature effects ; Therapy ; thermohydrogel ; Toxicity ; Tumors ; Xenograft Model Antitumor Assays</subject><ispartof>Macromolecular bioscience, 2017-05, Vol.17 (5), p.n/a</ispartof><rights>2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3731-2665e877f9c09c0e3035938e9c1e253e6a66b052d401abf8f70d15abc16e193</citedby><cites>FETCH-LOGICAL-c3731-2665e877f9c09c0e3035938e9c1e253e6a66b052d401abf8f70d15abc16e193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmabi.201600371$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmabi.201600371$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27906510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Miri</creatorcontrib><creatorcontrib>Kim, Hyun Soo</creatorcontrib><creatorcontrib>Kim, Min Ah</creatorcontrib><creatorcontrib>Ryu, Hyanghwa</creatorcontrib><creatorcontrib>Jeong, Hwan‐Jeong</creatorcontrib><creatorcontrib>Lee, Chang‐Moon</creatorcontrib><title>Thermohydrogel Containing Melanin for Photothermal Cancer Therapy</title><title>Macromolecular bioscience</title><addtitle>Macromol Biosci</addtitle><description>Melanin is an effective absorber of light and can extend to near infrared (NIR) regions. In this study, a natural melanin is presented as a photothermal therapeutic agent (PTA) because it provides a good photothermal conversion efficiency, shows biodegradability, and does not induce long‐term toxicity during retention in vivo. Poloxamer solution containing melanin (Pol–Mel) does not show any precipitation and shows sol–gel transition at body temperature. After irradiation from 808 nm NIR laser at 1.5 W cm−2 for 3 min, the photothermal conversion efficiency of Pol–Mel is enough to kill cancer cells in vitro and in vivo. The tumor growth of mice bearing CT26 tumors treated with Pol–Mel injection and laser irradiation is suppressed completely without recurrence postirradiation. All these results indicate that Pol–Mel can become an attractive PTA for photothermal cancer therapy.
Poloxamer solution containing melanin (Pol–Mel) shows sol–gel transition at body temperature after heat generation induced by near infrared 808 nm laser irradiation. Following intratumoral injection of Pol–Mel and the laser irradiation, the growth of the CT26 tumors is suppressed completely without recurrence. From these results, Pol–Mel is a potentially attractive photothermal therapeutic agent for cancer therapy.</description><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>Body temperature</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>cancer therapy</subject><subject>Cell Line, Tumor</subject><subject>Chemical compounds</subject><subject>Chemical precipitation</subject><subject>Humans</subject><subject>Hydrogels - chemistry</subject><subject>Hyperthermia, Induced - methods</subject><subject>Infrared Rays</subject><subject>Irradiation</subject><subject>Male</subject><subject>Melanin</subject><subject>Melanins - administration & dosage</subject><subject>Melanins - chemistry</subject><subject>Melanins - therapeutic use</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Neoplasms - therapy</subject><subject>Pharmacology</subject><subject>Phototherapy - methods</subject><subject>Photothermal conversion</subject><subject>photothermal therapy</subject><subject>Poloxamer</subject><subject>Sol-gel processes</subject><subject>Temperature effects</subject><subject>Therapy</subject><subject>thermohydrogel</subject><subject>Toxicity</subject><subject>Tumors</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1616-5187</issn><issn>1616-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M9LwzAUB_AgipvTq0cpePHSmdc0SXOcwx8Dh4K7l7R93TraZqYt0v_elM0JXoRA3uHzvjy-hFwDnQKlwX2lk2IaUBCUMgknZAwChM9B8dPjHMkRuWiaLaUgIxWck1EgFRUc6JjMVhu0ldn0mTVrLL25qVtd1EW99pZYajd4ubHe-8a0ph2odkbXKVpv2NS7_pKc5bps8OrwT8jH0-Nq_uK_vj0v5rNXP2WSgR8IwTGSMlcpdQ8ZZVyxCFUKGHCGQguRUB5kIQWd5FEuaQZcJykIBMUm5G6furPms8OmjauiSbF0J6LpmhiikAc8DJVw9PYP3ZrO1u42p1TkRCiYU9O9Sq1pGot5vLNFpW0fA42HauOh2vhYrVu4OcR2SYXZkf906YDag6-ixP6fuHg5e1j8hn8D-8mDxg</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Kim, Miri</creator><creator>Kim, Hyun Soo</creator><creator>Kim, Min Ah</creator><creator>Ryu, Hyanghwa</creator><creator>Jeong, Hwan‐Jeong</creator><creator>Lee, Chang‐Moon</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201705</creationdate><title>Thermohydrogel Containing Melanin for Photothermal Cancer Therapy</title><author>Kim, Miri ; Kim, Hyun Soo ; Kim, Min Ah ; Ryu, Hyanghwa ; Jeong, Hwan‐Jeong ; Lee, Chang‐Moon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3731-2665e877f9c09c0e3035938e9c1e253e6a66b052d401abf8f70d15abc16e193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Biocompatibility</topic><topic>Biodegradability</topic><topic>Body temperature</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>cancer therapy</topic><topic>Cell Line, Tumor</topic><topic>Chemical compounds</topic><topic>Chemical precipitation</topic><topic>Humans</topic><topic>Hydrogels - chemistry</topic><topic>Hyperthermia, Induced - methods</topic><topic>Infrared Rays</topic><topic>Irradiation</topic><topic>Male</topic><topic>Melanin</topic><topic>Melanins - administration & dosage</topic><topic>Melanins - chemistry</topic><topic>Melanins - therapeutic use</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Neoplasms - therapy</topic><topic>Pharmacology</topic><topic>Phototherapy - methods</topic><topic>Photothermal conversion</topic><topic>photothermal therapy</topic><topic>Poloxamer</topic><topic>Sol-gel processes</topic><topic>Temperature effects</topic><topic>Therapy</topic><topic>thermohydrogel</topic><topic>Toxicity</topic><topic>Tumors</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Miri</creatorcontrib><creatorcontrib>Kim, Hyun Soo</creatorcontrib><creatorcontrib>Kim, Min Ah</creatorcontrib><creatorcontrib>Ryu, Hyanghwa</creatorcontrib><creatorcontrib>Jeong, Hwan‐Jeong</creatorcontrib><creatorcontrib>Lee, Chang‐Moon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Macromolecular bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Miri</au><au>Kim, Hyun Soo</au><au>Kim, Min Ah</au><au>Ryu, Hyanghwa</au><au>Jeong, Hwan‐Jeong</au><au>Lee, Chang‐Moon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thermohydrogel Containing Melanin for Photothermal Cancer Therapy</atitle><jtitle>Macromolecular bioscience</jtitle><addtitle>Macromol Biosci</addtitle><date>2017-05</date><risdate>2017</risdate><volume>17</volume><issue>5</issue><epage>n/a</epage><issn>1616-5187</issn><eissn>1616-5195</eissn><abstract>Melanin is an effective absorber of light and can extend to near infrared (NIR) regions. In this study, a natural melanin is presented as a photothermal therapeutic agent (PTA) because it provides a good photothermal conversion efficiency, shows biodegradability, and does not induce long‐term toxicity during retention in vivo. Poloxamer solution containing melanin (Pol–Mel) does not show any precipitation and shows sol–gel transition at body temperature. After irradiation from 808 nm NIR laser at 1.5 W cm−2 for 3 min, the photothermal conversion efficiency of Pol–Mel is enough to kill cancer cells in vitro and in vivo. The tumor growth of mice bearing CT26 tumors treated with Pol–Mel injection and laser irradiation is suppressed completely without recurrence postirradiation. All these results indicate that Pol–Mel can become an attractive PTA for photothermal cancer therapy.
Poloxamer solution containing melanin (Pol–Mel) shows sol–gel transition at body temperature after heat generation induced by near infrared 808 nm laser irradiation. Following intratumoral injection of Pol–Mel and the laser irradiation, the growth of the CT26 tumors is suppressed completely without recurrence. From these results, Pol–Mel is a potentially attractive photothermal therapeutic agent for cancer therapy.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27906510</pmid><doi>10.1002/mabi.201600371</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biocompatibility Biodegradability Body temperature Cancer Cancer therapies cancer therapy Cell Line, Tumor Chemical compounds Chemical precipitation Humans Hydrogels - chemistry Hyperthermia, Induced - methods Infrared Rays Irradiation Male Melanin Melanins - administration & dosage Melanins - chemistry Melanins - therapeutic use Mice Mice, Inbred BALB C Neoplasms - therapy Pharmacology Phototherapy - methods Photothermal conversion photothermal therapy Poloxamer Sol-gel processes Temperature effects Therapy thermohydrogel Toxicity Tumors Xenograft Model Antitumor Assays |
| title | Thermohydrogel Containing Melanin for Photothermal Cancer Therapy |
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