Involvement of cAMP receptor protein in biofilm formation, fimbria production, capsular polysaccharide biosynthesis and lethality in mouse of Klebsiella pneumoniae serotype K1 causing pyogenic liver abscess

The global regulator cAMP receptor protein (CRP) has been shown to be required for the full virulence and/or for the expression of virulence determinants in a wide set of bacterial pathogens. In this work, the crp mutant as well as the complemented mutant was constructed from a wild-type Klebsiella...

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Veröffentlicht in:	Journal of medical microbiology 2017-01, Vol.66 (1), p.1-7
Hauptverfasser:	Ou, Qin, Fan, Jinming, Duan, Dejian, Xu, Li, Wang, Jie, Zhou, Dongsheng, Yang, Huiying, Li, Bei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Capsules - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism Biofilms - growth & development Cyclic AMP Receptor Protein - genetics Cyclic AMP Receptor Protein - metabolism Female Fimbriae, Bacterial - metabolism Gene Deletion Gene Expression Regulation, Bacterial Klebsiella pneumoniae - genetics Klebsiella pneumoniae - metabolism Klebsiella pneumoniae - pathogenicity Liver Abscess, Pyogenic - microbiology Liver Abscess, Pyogenic - pathology Mice Mice, Inbred BALB C Polysaccharides, Bacterial RNA, Bacterial - genetics Serotyping Virulence
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