Stress-Activated Kinase Mitogen-Activated Kinase Kinase-7 Governs Epigenetics of Cardiac Repolarization for Arrhythmia Prevention

BACKGROUND:Ventricular arrhythmia is a leading cause of cardiac mortality. Most antiarrhythmics present paradoxical proarrhythmic side effects, culminating in a greater risk of sudden death. METHODS:We describe a new regulatory mechanism linking mitogen-activated kinase kinase-7 deficiency with incr...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2017-02, Vol.135 (7), p.683-699
Hauptverfasser:	Chowdhury, Sanjoy K, Liu, Wei, Zi, Min, Li, Yatong, Wang, Shunyao, Tsui, Hoyee, Prehar, Sukhpal, Castro, Simon, Zhang, Henggui, Ji, Yong, Zhang, Xiuqin, Xiao, Ruiping, Zhang, Rongli, Lei, Ming, Cyganek, Lukas, Guan, Kaomei, Millar, Catherine B, Liao, Xudong, Jain, Mukesh K, Boyett, Mark R, Cartwright, Elizabeth J, Shiels, Holly A, Wang, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmias, Cardiac - physiopathology Arrhythmias, Cardiac - prevention & control Epigenesis, Genetic Humans Kruppel-Like Factor 4 MAP Kinase Kinase 7 - metabolism Mice Myocytes, Cardiac - metabolism Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!