Sulfation of R(--)-apomorphine in the human liver and duodenum, and its inhibition by mefenamic acid, salicylic acid and quercetin

1. The aims were to study the sulfation of R-(--)-apomorphine (hereafter apomorphine) in the human liver and duodenum, and to study the rate of inhibition of apomorphine sulphation by mefenamic acid, salicylic acid and quercetin also in the human liver and duodenum. 2. A rapid and sensitive method w...

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Veröffentlicht in:	Xenobiotica 2002, Vol.32 (7), p.587-594
Hauptverfasser:	Vietri, M., Vaglini, F., Pietrabissa, A., Spisni, R., Mosca, F., Pacifici, G. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anticonvulsants. Antiepileptics. Antiparkinson agents Apomorphine - chemistry Apomorphine - metabolism Arylsulfotransferase Biological and medical sciences Duodenum - drug effects Duodenum - metabolism Female Humans In Vitro Techniques Kinetics Liver - drug effects Liver - metabolism Male Medical sciences Mefenamic Acid - pharmacology Middle Aged Neuropharmacology Pharmacology. Drug treatments Quercetin - pharmacology Salicylic Acid - pharmacology Stereoisomerism Sulfates - metabolism Sulfotransferases - antagonists & inhibitors Sulfotransferases - metabolism
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