Reduced aversion to oral capsaicin following neurotoxic destruction of superficial medullary neurons expressing NK-1 receptors

Aversion to capsaicin (0.1–10 ppm) was assessed using a two-bottle paired preference paradigm, before and after intracisternal injection of substance P conjugated to saporin (SP-SAP) to ablate neurons in superficial medullary and cervical dorsal horn that express NK-1 receptors. Before SP-SAP, there...

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Veröffentlicht in:	Brain research 2002-07, Vol.945 (1), p.139-143
Hauptverfasser:	Simons, Christopher T, Gogineni, Alvin G, Iodi Carstens, Mirela, Carstens, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Aversion Biological and medical sciences Capsaicin Capsaicin - administration & dosage Cervical Vertebrae Fundamental and applied biological sciences. Psychology Injections, Intraventricular Irritants - administration & dosage Male Medulla Oblongata - pathology Medulla Oblongata - physiopathology Neurons - physiology Oral irritation Pain - chemically induced Pain - physiopathology Pain Threshold - physiology Rats Rats, Sprague-Dawley Receptors, Neurokinin-1 - metabolism Solutions Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord - pathology Spinal Cord - physiopathology Substance P Substance P - administration & dosage Substance P - pharmacology Trigeminal caudalis Vertebrates: nervous system and sense organs
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