The Effects of Atrazine Metabolites on Puberty and Thyroid Function in the Male Wistar Rat
Recently we reported that atrazine (ATR), a chlorotriazine herbicide, alters the onset of puberty in male Wistar rats. In this study, we examined the same reproductive parameters in the developing male rat following a similar exposure to the primary, chlorinated metabolites of atrazine. Intact male...
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| Veröffentlicht in: | Toxicological sciences 2002-06, Vol.67 (2), p.198-206 |
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| creator | Stoker, T. E. Guidici, D. L. Laws, S. C. Cooper, R. L. |
| description | Recently we reported that atrazine (ATR), a chlorotriazine herbicide, alters the onset of puberty in male Wistar rats. In this study, we examined the same reproductive parameters in the developing male rat following a similar exposure to the primary, chlorinated metabolites of atrazine. Intact male Wistar rats were gavaged from postnatal day (PND) 23 through PND 53 and several reproductive endpoints were examined. The doses selected were the molar equivalents to atrazine in our previous work. Deethylatrazine (DEA), deisopropyl-atrazine (DIA), and diaminochlorotriazine (DACT) were administered by gavage at doses equivalent to the atrazine equimolar doses (AED) of 6.25, 12.5, 25, 50, 100, or 200 mg/kg. Preputial separation (PPS) was significantly delayed by DEA at 25, 100, and 200 AED, by DIA at 25, 100, and 200 AED, and by DACT at 12.5 through 200 AED. When the males were killed on PND 53, DEA (100 and 200 AED), DIA (50 through 200 AED), and DACT (200 AED) treatments caused a significant reduction in ventral prostate weight, while only the highest doses of DIA and DEA resulted in a significant decrease in lateral prostate weight. Seminal vesicle weight was reduced by DEA (25, 100, and 200 AED), DIA (100 and 200 AED), and 100 and 200 AED of DACT. Epididymal weights were reduced in the DEA (200 AED), DIA (200 AED), and DACT (100 and 200 AED) treatment groups. Serum testosterone was reduced only in the males receiving the 2 highest doses of DIA. Serum estrone was increased in the 2 highest doses of the DACT group, while serum estradiol was not different in any group. No differences were observed in any of the thyroid measures. In summary, the metabolites of ATR delay puberty in a manner similar to that observed in the previous study testing atrazine. These data also suggest that the 3 chlorinated metabolites are similar to ATR, by affecting the CNS control of the pituitary/gonadal axis and subsequent development of the reproductive tract. |
| doi_str_mv | 10.1093/toxsci/67.2.198 |
| format | Article |
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E. ; Guidici, D. L. ; Laws, S. C. ; Cooper, R. L.</creator><creatorcontrib>Stoker, T. E. ; Guidici, D. L. ; Laws, S. C. ; Cooper, R. L.</creatorcontrib><description>Recently we reported that atrazine (ATR), a chlorotriazine herbicide, alters the onset of puberty in male Wistar rats. In this study, we examined the same reproductive parameters in the developing male rat following a similar exposure to the primary, chlorinated metabolites of atrazine. Intact male Wistar rats were gavaged from postnatal day (PND) 23 through PND 53 and several reproductive endpoints were examined. The doses selected were the molar equivalents to atrazine in our previous work. Deethylatrazine (DEA), deisopropyl-atrazine (DIA), and diaminochlorotriazine (DACT) were administered by gavage at doses equivalent to the atrazine equimolar doses (AED) of 6.25, 12.5, 25, 50, 100, or 200 mg/kg. Preputial separation (PPS) was significantly delayed by DEA at 25, 100, and 200 AED, by DIA at 25, 100, and 200 AED, and by DACT at 12.5 through 200 AED. When the males were killed on PND 53, DEA (100 and 200 AED), DIA (50 through 200 AED), and DACT (200 AED) treatments caused a significant reduction in ventral prostate weight, while only the highest doses of DIA and DEA resulted in a significant decrease in lateral prostate weight. Seminal vesicle weight was reduced by DEA (25, 100, and 200 AED), DIA (100 and 200 AED), and 100 and 200 AED of DACT. Epididymal weights were reduced in the DEA (200 AED), DIA (200 AED), and DACT (100 and 200 AED) treatment groups. Serum testosterone was reduced only in the males receiving the 2 highest doses of DIA. Serum estrone was increased in the 2 highest doses of the DACT group, while serum estradiol was not different in any group. No differences were observed in any of the thyroid measures. In summary, the metabolites of ATR delay puberty in a manner similar to that observed in the previous study testing atrazine. These data also suggest that the 3 chlorinated metabolites are similar to ATR, by affecting the CNS control of the pituitary/gonadal axis and subsequent development of the reproductive tract.</description><identifier>ISSN: 1096-6080</identifier><identifier>ISSN: 1096-0929</identifier><identifier>EISSN: 1096-0929</identifier><identifier>DOI: 10.1093/toxsci/67.2.198</identifier><identifier>PMID: 12011479</identifier><identifier>CODEN: TOSCF2</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Animals ; atrazine ; Atrazine - analogs & derivatives ; Atrazine - metabolism ; Atrazine - toxicity ; Biological and medical sciences ; Body Weight - drug effects ; deethylatrazine ; deisopropylatrazine ; diaminochlorotriazine ; Estradiol - blood ; Genitalia, Male - drug effects ; Genitalia, Male - pathology ; Herbicides - metabolism ; Herbicides - toxicity ; Hormone Antagonists - metabolism ; Hormone Antagonists - toxicity ; hormones ; Male ; Medical sciences ; Organ Size - drug effects ; Pesticides, fertilizers and other agrochemicals toxicology ; Pituitary Gland, Anterior - drug effects ; Pituitary Gland, Anterior - pathology ; preputial separation ; puberty ; Rats ; Rats, Wistar ; reproductive tract ; Sexual Maturation - drug effects ; Sexual Maturation - physiology ; Testosterone - blood ; Thyroid Gland - drug effects ; Thyroid Gland - physiopathology ; Thyroid Hormones - blood ; Toxicology ; Triazines - toxicity</subject><ispartof>Toxicological sciences, 2002-06, Vol.67 (2), p.198-206</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-85e8c5facc710ec64fc05a419a4c05a482e27a2ee2c8134d6fd2687770c878963</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13705925$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12011479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stoker, T. E.</creatorcontrib><creatorcontrib>Guidici, D. L.</creatorcontrib><creatorcontrib>Laws, S. C.</creatorcontrib><creatorcontrib>Cooper, R. L.</creatorcontrib><title>The Effects of Atrazine Metabolites on Puberty and Thyroid Function in the Male Wistar Rat</title><title>Toxicological sciences</title><addtitle>Toxicol. Sci</addtitle><description>Recently we reported that atrazine (ATR), a chlorotriazine herbicide, alters the onset of puberty in male Wistar rats. In this study, we examined the same reproductive parameters in the developing male rat following a similar exposure to the primary, chlorinated metabolites of atrazine. Intact male Wistar rats were gavaged from postnatal day (PND) 23 through PND 53 and several reproductive endpoints were examined. The doses selected were the molar equivalents to atrazine in our previous work. Deethylatrazine (DEA), deisopropyl-atrazine (DIA), and diaminochlorotriazine (DACT) were administered by gavage at doses equivalent to the atrazine equimolar doses (AED) of 6.25, 12.5, 25, 50, 100, or 200 mg/kg. Preputial separation (PPS) was significantly delayed by DEA at 25, 100, and 200 AED, by DIA at 25, 100, and 200 AED, and by DACT at 12.5 through 200 AED. When the males were killed on PND 53, DEA (100 and 200 AED), DIA (50 through 200 AED), and DACT (200 AED) treatments caused a significant reduction in ventral prostate weight, while only the highest doses of DIA and DEA resulted in a significant decrease in lateral prostate weight. Seminal vesicle weight was reduced by DEA (25, 100, and 200 AED), DIA (100 and 200 AED), and 100 and 200 AED of DACT. Epididymal weights were reduced in the DEA (200 AED), DIA (200 AED), and DACT (100 and 200 AED) treatment groups. Serum testosterone was reduced only in the males receiving the 2 highest doses of DIA. Serum estrone was increased in the 2 highest doses of the DACT group, while serum estradiol was not different in any group. No differences were observed in any of the thyroid measures. In summary, the metabolites of ATR delay puberty in a manner similar to that observed in the previous study testing atrazine. These data also suggest that the 3 chlorinated metabolites are similar to ATR, by affecting the CNS control of the pituitary/gonadal axis and subsequent development of the reproductive tract.</description><subject>Animals</subject><subject>atrazine</subject><subject>Atrazine - analogs & derivatives</subject><subject>Atrazine - metabolism</subject><subject>Atrazine - toxicity</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>deethylatrazine</subject><subject>deisopropylatrazine</subject><subject>diaminochlorotriazine</subject><subject>Estradiol - blood</subject><subject>Genitalia, Male - drug effects</subject><subject>Genitalia, Male - pathology</subject><subject>Herbicides - metabolism</subject><subject>Herbicides - toxicity</subject><subject>Hormone Antagonists - metabolism</subject><subject>Hormone Antagonists - toxicity</subject><subject>hormones</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Organ Size - drug effects</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Pituitary Gland, Anterior - drug effects</subject><subject>Pituitary Gland, Anterior - pathology</subject><subject>preputial separation</subject><subject>puberty</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>reproductive tract</subject><subject>Sexual Maturation - drug effects</subject><subject>Sexual Maturation - physiology</subject><subject>Testosterone - blood</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - physiopathology</subject><subject>Thyroid Hormones - blood</subject><subject>Toxicology</subject><subject>Triazines - toxicity</subject><issn>1096-6080</issn><issn>1096-0929</issn><issn>1096-0929</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1P3DAURS3UCiiwZoe8aXeZsR3HH0s0QKkEKipTFc3G8jjPwpBJwHYkpr--bicqK1-9d3yfdBA6pWRGia7neXhLLsyFnLEZ1WoPHZaxqIhm-sOUBVHkAH1K6YkQSgXR--iAshK51IdotXwEfOk9uJzw4PF5jvZ36AHfQrbroQsZyrzHd-MaYt5i27d4-biNQ2jx1di7HMoy9DiXmlvbAf4VUrYR_7D5GH30tktwMr1H6OfV5XJxXd18__ptcX5TOa51rlQDyjXeOicpASe4d6SxnGrL_wXFgEnLAJhTtOat8C0TSkpJnJJKi_oIfdn1vsThdYSUzSYkB11nexjGZKjiXDRKF3C-A10cUorgzUsMGxu3hhLzV6fZ6TRCGmaKzvLjbKoe1xto3_nJXwE-T4BNznY-2t6F9M7VkjSaNYWrdlyxA2__9zY-l2O1bMz1w8rcL1aNFvzOXNR_AOmPjak</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Stoker, T. E.</creator><creator>Guidici, D. L.</creator><creator>Laws, S. C.</creator><creator>Cooper, R. L.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20020601</creationdate><title>The Effects of Atrazine Metabolites on Puberty and Thyroid Function in the Male Wistar Rat</title><author>Stoker, T. E. ; Guidici, D. L. ; Laws, S. C. ; Cooper, R. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-85e8c5facc710ec64fc05a419a4c05a482e27a2ee2c8134d6fd2687770c878963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>atrazine</topic><topic>Atrazine - analogs & derivatives</topic><topic>Atrazine - metabolism</topic><topic>Atrazine - toxicity</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>deethylatrazine</topic><topic>deisopropylatrazine</topic><topic>diaminochlorotriazine</topic><topic>Estradiol - blood</topic><topic>Genitalia, Male - drug effects</topic><topic>Genitalia, Male - pathology</topic><topic>Herbicides - metabolism</topic><topic>Herbicides - toxicity</topic><topic>Hormone Antagonists - metabolism</topic><topic>Hormone Antagonists - toxicity</topic><topic>hormones</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Organ Size - drug effects</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Pituitary Gland, Anterior - drug effects</topic><topic>Pituitary Gland, Anterior - pathology</topic><topic>preputial separation</topic><topic>puberty</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>reproductive tract</topic><topic>Sexual Maturation - drug effects</topic><topic>Sexual Maturation - physiology</topic><topic>Testosterone - blood</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Gland - physiopathology</topic><topic>Thyroid Hormones - blood</topic><topic>Toxicology</topic><topic>Triazines - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stoker, T. E.</creatorcontrib><creatorcontrib>Guidici, D. L.</creatorcontrib><creatorcontrib>Laws, S. C.</creatorcontrib><creatorcontrib>Cooper, R. L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stoker, T. E.</au><au>Guidici, D. L.</au><au>Laws, S. C.</au><au>Cooper, R. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Atrazine Metabolites on Puberty and Thyroid Function in the Male Wistar Rat</atitle><jtitle>Toxicological sciences</jtitle><addtitle>Toxicol. Sci</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>67</volume><issue>2</issue><spage>198</spage><epage>206</epage><pages>198-206</pages><issn>1096-6080</issn><issn>1096-0929</issn><eissn>1096-0929</eissn><coden>TOSCF2</coden><abstract>Recently we reported that atrazine (ATR), a chlorotriazine herbicide, alters the onset of puberty in male Wistar rats. In this study, we examined the same reproductive parameters in the developing male rat following a similar exposure to the primary, chlorinated metabolites of atrazine. Intact male Wistar rats were gavaged from postnatal day (PND) 23 through PND 53 and several reproductive endpoints were examined. The doses selected were the molar equivalents to atrazine in our previous work. Deethylatrazine (DEA), deisopropyl-atrazine (DIA), and diaminochlorotriazine (DACT) were administered by gavage at doses equivalent to the atrazine equimolar doses (AED) of 6.25, 12.5, 25, 50, 100, or 200 mg/kg. Preputial separation (PPS) was significantly delayed by DEA at 25, 100, and 200 AED, by DIA at 25, 100, and 200 AED, and by DACT at 12.5 through 200 AED. When the males were killed on PND 53, DEA (100 and 200 AED), DIA (50 through 200 AED), and DACT (200 AED) treatments caused a significant reduction in ventral prostate weight, while only the highest doses of DIA and DEA resulted in a significant decrease in lateral prostate weight. Seminal vesicle weight was reduced by DEA (25, 100, and 200 AED), DIA (100 and 200 AED), and 100 and 200 AED of DACT. Epididymal weights were reduced in the DEA (200 AED), DIA (200 AED), and DACT (100 and 200 AED) treatment groups. Serum testosterone was reduced only in the males receiving the 2 highest doses of DIA. Serum estrone was increased in the 2 highest doses of the DACT group, while serum estradiol was not different in any group. No differences were observed in any of the thyroid measures. In summary, the metabolites of ATR delay puberty in a manner similar to that observed in the previous study testing atrazine. These data also suggest that the 3 chlorinated metabolites are similar to ATR, by affecting the CNS control of the pituitary/gonadal axis and subsequent development of the reproductive tract.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>12011479</pmid><doi>10.1093/toxsci/67.2.198</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals atrazine Atrazine - analogs & derivatives Atrazine - metabolism Atrazine - toxicity Biological and medical sciences Body Weight - drug effects deethylatrazine deisopropylatrazine diaminochlorotriazine Estradiol - blood Genitalia, Male - drug effects Genitalia, Male - pathology Herbicides - metabolism Herbicides - toxicity Hormone Antagonists - metabolism Hormone Antagonists - toxicity hormones Male Medical sciences Organ Size - drug effects Pesticides, fertilizers and other agrochemicals toxicology Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - pathology preputial separation puberty Rats Rats, Wistar reproductive tract Sexual Maturation - drug effects Sexual Maturation - physiology Testosterone - blood Thyroid Gland - drug effects Thyroid Gland - physiopathology Thyroid Hormones - blood Toxicology Triazines - toxicity |
| title | The Effects of Atrazine Metabolites on Puberty and Thyroid Function in the Male Wistar Rat |
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