Genotoxic effect of ozone in human peripheral blood leukocytes

The genotoxic effect of ozone was studied in human leukocytes in vitro, using the single cell gel electrophoresis (SCGE) assay. Cell treatment for 1 h at 37 °C with 0.9–5.3 mM O 3 resulted in a dose-dependent increase of DNA damage, comparable to that induced by 4–40 mM of H 2O 2, used as a positive...

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Veröffentlicht in:	Mutation research 2002-05, Vol.517 (1), p.13-20
Hauptverfasser:	Dı́az-Llera, Silvia, González-Hernández, Yanela, Prieto-González, E.A, Azoy, Angel
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Catalase Catalase - therapeutic use Cells, Cultured Comet Assay DNA Damage Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Human leukocytes Humans Leukocytes - metabolism Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Oxygen - pharmacology Ozone Ozone - pharmacology Pharmacology. Drug treatments SCGE
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