Determination of a CD4+CD25−FoxP3+ T cells subset in tumor-draining lymph nodes of colorectal cancer secreting IL-2 and IFN-γ

CD4 + CD25 − FoxP3 + cells are a newly recognized subset of T cells which was first reported in autoimmune diseases. In our previous study, this subset was detected in tumor-draining lymph nodes (TDLNs) of patients with breast cancer. As little is known about their function in TDLNs of cancer patien...

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Veröffentlicht in:	Tumor biology 2016-11, Vol.37 (11), p.14659-14666
Hauptverfasser:	Jafarinia, Morteza, Mehdipour, Fereshteh, Hosseini, Seyed Vahid, Ghahramani, Leila, Hosseinzadeh, Masood, Ghaderi, Abbas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - immunology Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Cancer Research CD4-Positive T-Lymphocytes - metabolism Colorectal Neoplasms - immunology Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Female Flow Cytometry Forkhead Transcription Factors - metabolism Humans Interferon-gamma - metabolism Interleukin-2 Receptor alpha Subunit - metabolism Lymph Nodes - immunology Lymph Nodes - metabolism Lymph Nodes - pathology Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Lymphocytes, Tumor-Infiltrating - pathology Male Middle Aged Original Article T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - pathology Tumor Cells, Cultured Young Adult
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