Dose-Response Modeling of Continuous Endpoints

A family of (nested) dose-response models is introduced herein that can be used for describing the change in any continuous endpoint as a function of dose. A member from this family of models may be selected using the likelihood ratio test as a criterion, to prevent overparameterization. The propose...

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Veröffentlicht in:	Toxicological sciences 2002-04, Vol.66 (2), p.298-312
1. Verfasser:	SLOB, Wout
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals benchmark dose Biological and medical sciences continuous endpoints critical effect size Data Interpretation, Statistical dose-response modeling Dose-Response Relationship, Drug Endpoint Determination Female General aspects. Methods Male Medical sciences Models, Statistical Nonlinear Dynamics probabilistic assessment factor Toxicology Toxicology - methods
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