The protective role of thiola and soybean seeds against the genotoxicity induced by potassium dichromate in mice
The genotoxic potential of potassium dichromate (K 2Cr 2O 7) was evaluated in vivo in mice using different mutagenic end points. Chromosomal aberrations in bone-marrow and spermatocytes as well as sperm abnormalities in the tested mice were determined. The doses used were 3, 6, 12 mg K 2Cr 2O 7 kg −...
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| Veröffentlicht in: | Mutation research 2002-05, Vol.517 (1), p.1-12 |
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| creator | Fahmy, Maha A. Shoman, Hoda M. Hassan, Entesar E.S. |
| description | The genotoxic potential of potassium dichromate (K
2Cr
2O
7) was evaluated in vivo in mice using different mutagenic end points. Chromosomal aberrations in bone-marrow and spermatocytes as well as sperm abnormalities in the tested mice were determined. The doses used were 3, 6, 12
mg K
2Cr
2O
7
kg
−1 body weight which correspond to 1/16, 1/8, 1/4 the experimental LD
50, respectively. The protective roles of i.p. injection with thiola (a synthetic sulfhydryl compound) at 20
mg
kg
−1 body weight and feeding treatment with soybean seeds (30% of the diet) were also studied.
For chromosomal aberration analysis, subacute treatment for a period of 3 weeks were performed. All the tested doses of K
2Cr
2O
7 induced a statistically significant increase in the percentage of chromosomal aberrations in both somatic and germ cells with dose and time relationships. The percentage of the induced chromosomal aberrations was significantly minimized in all groups of mice i.p. treated with thiola or fed soybean seeds during the period of treatment.
Potassium dichromate also induced a significant increase (
P |
| doi_str_mv | 10.1016/S1383-5718(02)00013-X |
| format | Article |
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2Cr
2O
7) was evaluated in vivo in mice using different mutagenic end points. Chromosomal aberrations in bone-marrow and spermatocytes as well as sperm abnormalities in the tested mice were determined. The doses used were 3, 6, 12
mg K
2Cr
2O
7
kg
−1 body weight which correspond to 1/16, 1/8, 1/4 the experimental LD
50, respectively. The protective roles of i.p. injection with thiola (a synthetic sulfhydryl compound) at 20
mg
kg
−1 body weight and feeding treatment with soybean seeds (30% of the diet) were also studied.
For chromosomal aberration analysis, subacute treatment for a period of 3 weeks were performed. All the tested doses of K
2Cr
2O
7 induced a statistically significant increase in the percentage of chromosomal aberrations in both somatic and germ cells with dose and time relationships. The percentage of the induced chromosomal aberrations was significantly minimized in all groups of mice i.p. treated with thiola or fed soybean seeds during the period of treatment.
Potassium dichromate also induced a significant increase (
P<0.01) in the percentage of abnormal sperms at the doses 6 and 12
mg
kg
−1 body weight. Such percentage reached 7.52±0.45, 5.50±0.53 and 4.28±0.45 in mice treated with the highest tested dose of K
2Cr
2O
7, K
2Cr
2O
7 and thiola; K
2Cr
2O
7 and soybean, respectively compared with 2.14±0.33 for the control.
In conclusion, the results demonstrate the genotoxic effect of potassium dichromate in mice. The results also confirm the protective role of thiola and soybean seeds against the genotoxicity of potassium dichromate.</description><identifier>ISSN: 1383-5718</identifier><identifier>ISSN: 0027-5107</identifier><identifier>EISSN: 1879-3592</identifier><identifier>DOI: 10.1016/S1383-5718(02)00013-X</identifier><identifier>PMID: 12034303</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Bone Marrow - drug effects ; Chemical mutagenesis ; Chromosome Aberrations - drug effects ; Dose-Response Relationship, Drug ; Genotoxicity ; Glycine max - metabolism ; In vivo (mice) ; Male ; Medical sciences ; Mice ; Mutation ; Plant Extracts - therapeutic use ; Potassium dichromate (K 2Cr 2O 7) ; Potassium Dichromate - toxicity ; Protection ; Spermatozoa - drug effects ; Tiopronin - therapeutic use ; Toxicology</subject><ispartof>Mutation research, 2002-05, Vol.517 (1), p.1-12</ispartof><rights>2002</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-329bd1ab7c48e608eda77889ebd412bd8eec25dc12216a6d3183ce026daa938e3</citedby><cites>FETCH-LOGICAL-c422t-329bd1ab7c48e608eda77889ebd412bd8eec25dc12216a6d3183ce026daa938e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S138357180200013X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13686519$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12034303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fahmy, Maha A.</creatorcontrib><creatorcontrib>Shoman, Hoda M.</creatorcontrib><creatorcontrib>Hassan, Entesar E.S.</creatorcontrib><title>The protective role of thiola and soybean seeds against the genotoxicity induced by potassium dichromate in mice</title><title>Mutation research</title><addtitle>Mutat Res</addtitle><description>The genotoxic potential of potassium dichromate (K
2Cr
2O
7) was evaluated in vivo in mice using different mutagenic end points. Chromosomal aberrations in bone-marrow and spermatocytes as well as sperm abnormalities in the tested mice were determined. The doses used were 3, 6, 12
mg K
2Cr
2O
7
kg
−1 body weight which correspond to 1/16, 1/8, 1/4 the experimental LD
50, respectively. The protective roles of i.p. injection with thiola (a synthetic sulfhydryl compound) at 20
mg
kg
−1 body weight and feeding treatment with soybean seeds (30% of the diet) were also studied.
For chromosomal aberration analysis, subacute treatment for a period of 3 weeks were performed. All the tested doses of K
2Cr
2O
7 induced a statistically significant increase in the percentage of chromosomal aberrations in both somatic and germ cells with dose and time relationships. The percentage of the induced chromosomal aberrations was significantly minimized in all groups of mice i.p. treated with thiola or fed soybean seeds during the period of treatment.
Potassium dichromate also induced a significant increase (
P<0.01) in the percentage of abnormal sperms at the doses 6 and 12
mg
kg
−1 body weight. Such percentage reached 7.52±0.45, 5.50±0.53 and 4.28±0.45 in mice treated with the highest tested dose of K
2Cr
2O
7, K
2Cr
2O
7 and thiola; K
2Cr
2O
7 and soybean, respectively compared with 2.14±0.33 for the control.
In conclusion, the results demonstrate the genotoxic effect of potassium dichromate in mice. The results also confirm the protective role of thiola and soybean seeds against the genotoxicity of potassium dichromate.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - drug effects</subject><subject>Chemical mutagenesis</subject><subject>Chromosome Aberrations - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Genotoxicity</subject><subject>Glycine max - metabolism</subject><subject>In vivo (mice)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mutation</subject><subject>Plant Extracts - therapeutic use</subject><subject>Potassium dichromate (K 2Cr 2O 7)</subject><subject>Potassium Dichromate - toxicity</subject><subject>Protection</subject><subject>Spermatozoa - drug effects</subject><subject>Tiopronin - therapeutic use</subject><subject>Toxicology</subject><issn>1383-5718</issn><issn>0027-5107</issn><issn>1879-3592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhi1EVSjtT6Dyhao9pHjsfDgnVKF-SUg9QCVu1sSeZY2SeLEd1P33NexWHHuaV5pn7PFjxk5BfAYB7fk1KK2qpgP9UchPQghQ1e0BOwbd9ZVqenlY8j_kiL1J6V4IKZTQr9kRlFAroY7Z5mZNfBNDJpv9I_EYRuJhxfPahxE5zo6nsB0IZ56IXOJ4h35OuQDE72gOOfzx1uct97NbLDk-bPkmZEzJLxN33q5jmDBT6fPJW3rLXq1wTPRuX0_Y729fby5_VFe_vv-8_HJV2VrKXCnZDw5w6GytqRWaHHad1j0NrgY5OE1kZeMsSAkttk6BVpaEbB1irzSpE_Zhd2553MNCKZvJJ0vjiDOFJRnQdd0A1AVsdqCNIaVIK7OJfsK4NSDMk2rzrNo8eTRCmmfV5rbMvd9fsAwTuZepvdsCnO0BTBbHVcTZ-vTCqVa3DfSFu9hxVHQ8eoomWU9zcelj-RXjgv_PKn8BrcWdGg</recordid><startdate>20020527</startdate><enddate>20020527</enddate><creator>Fahmy, Maha A.</creator><creator>Shoman, Hoda M.</creator><creator>Hassan, Entesar E.S.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20020527</creationdate><title>The protective role of thiola and soybean seeds against the genotoxicity induced by potassium dichromate in mice</title><author>Fahmy, Maha A. ; Shoman, Hoda M. ; Hassan, Entesar E.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-329bd1ab7c48e608eda77889ebd412bd8eec25dc12216a6d3183ce026daa938e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - drug effects</topic><topic>Chemical mutagenesis</topic><topic>Chromosome Aberrations - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Genotoxicity</topic><topic>Glycine max - metabolism</topic><topic>In vivo (mice)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mutation</topic><topic>Plant Extracts - therapeutic use</topic><topic>Potassium dichromate (K 2Cr 2O 7)</topic><topic>Potassium Dichromate - toxicity</topic><topic>Protection</topic><topic>Spermatozoa - drug effects</topic><topic>Tiopronin - therapeutic use</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fahmy, Maha A.</creatorcontrib><creatorcontrib>Shoman, Hoda M.</creatorcontrib><creatorcontrib>Hassan, Entesar E.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Mutation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fahmy, Maha A.</au><au>Shoman, Hoda M.</au><au>Hassan, Entesar E.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The protective role of thiola and soybean seeds against the genotoxicity induced by potassium dichromate in mice</atitle><jtitle>Mutation research</jtitle><addtitle>Mutat Res</addtitle><date>2002-05-27</date><risdate>2002</risdate><volume>517</volume><issue>1</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>1383-5718</issn><issn>0027-5107</issn><eissn>1879-3592</eissn><abstract>The genotoxic potential of potassium dichromate (K
2Cr
2O
7) was evaluated in vivo in mice using different mutagenic end points. Chromosomal aberrations in bone-marrow and spermatocytes as well as sperm abnormalities in the tested mice were determined. The doses used were 3, 6, 12
mg K
2Cr
2O
7
kg
−1 body weight which correspond to 1/16, 1/8, 1/4 the experimental LD
50, respectively. The protective roles of i.p. injection with thiola (a synthetic sulfhydryl compound) at 20
mg
kg
−1 body weight and feeding treatment with soybean seeds (30% of the diet) were also studied.
For chromosomal aberration analysis, subacute treatment for a period of 3 weeks were performed. All the tested doses of K
2Cr
2O
7 induced a statistically significant increase in the percentage of chromosomal aberrations in both somatic and germ cells with dose and time relationships. The percentage of the induced chromosomal aberrations was significantly minimized in all groups of mice i.p. treated with thiola or fed soybean seeds during the period of treatment.
Potassium dichromate also induced a significant increase (
P<0.01) in the percentage of abnormal sperms at the doses 6 and 12
mg
kg
−1 body weight. Such percentage reached 7.52±0.45, 5.50±0.53 and 4.28±0.45 in mice treated with the highest tested dose of K
2Cr
2O
7, K
2Cr
2O
7 and thiola; K
2Cr
2O
7 and soybean, respectively compared with 2.14±0.33 for the control.
In conclusion, the results demonstrate the genotoxic effect of potassium dichromate in mice. The results also confirm the protective role of thiola and soybean seeds against the genotoxicity of potassium dichromate.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12034303</pmid><doi>10.1016/S1383-5718(02)00013-X</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1383-5718 |
| ispartof | Mutation research, 2002-05, Vol.517 (1), p.1-12 |
| issn | 1383-5718 0027-5107 1879-3592 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_18445114 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Bone Marrow - drug effects Chemical mutagenesis Chromosome Aberrations - drug effects Dose-Response Relationship, Drug Genotoxicity Glycine max - metabolism In vivo (mice) Male Medical sciences Mice Mutation Plant Extracts - therapeutic use Potassium dichromate (K 2Cr 2O 7) Potassium Dichromate - toxicity Protection Spermatozoa - drug effects Tiopronin - therapeutic use Toxicology |
| title | The protective role of thiola and soybean seeds against the genotoxicity induced by potassium dichromate in mice |
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