Nephrotoxicity in rats induced by chlorpryfos-ethyl and ameliorating effects of antioxidants
Nephrotoxicity induced by chlorpyrifos-ethyl (CE) and ameliorating effects of melatonin and vitamin E plus vitamin C were evaluated in rats exposed to CE. Experimental groups were as follows: control (C), CE treated (CE), vitamin E plus vitamin C treated (Vit), melatonin treated (Mel), vitamin E plu...
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| Veröffentlicht in: | Human & experimental toxicology 2002-04, Vol.21 (4), p.223-230 |
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| description | Nephrotoxicity induced by chlorpyrifos-ethyl (CE) and ameliorating effects of melatonin and vitamin E plus vitamin C were evaluated in rats exposed to CE. Experimental groups were as follows: control (C), CE treated (CE), vitamin E plus vitamin C treated (Vit), melatonin treated (Mel), vitamin E plus vitamin C plus CE treated (Vit+CE), and melatonin plus CE treated (Mel+CE). The rats in the CE, Vit+CE and Mel+CE groups were administered orally with CE in two equal doses of 41 mg/kg body weight (0.25 LD50). Melatonin and vitamins E and C were administrated intramuscularly at the doses of 10, 150 and 200 mg/kg, respectively. The levels of thiobarbituric acid reactive substance (TBARS) and antioxidant potential (AOP), and the activities of glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD) were studied in the homogenates of kidney tissue. There were no significant differences in the activities of SOD and CAT between the experimental groups. The level of TBARS increased significantly (P |
| doi_str_mv | 10.1191/0960327102ht225oa |
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Experimental groups were as follows: control (C), CE treated (CE), vitamin E plus vitamin C treated (Vit), melatonin treated (Mel), vitamin E plus vitamin C plus CE treated (Vit+CE), and melatonin plus CE treated (Mel+CE). The rats in the CE, Vit+CE and Mel+CE groups were administered orally with CE in two equal doses of 41 mg/kg body weight (0.25 LD50). Melatonin and vitamins E and C were administrated intramuscularly at the doses of 10, 150 and 200 mg/kg, respectively. The levels of thiobarbituric acid reactive substance (TBARS) and antioxidant potential (AOP), and the activities of glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD) were studied in the homogenates of kidney tissue. There were no significant differences in the activities of SOD and CAT between the experimental groups. The level of TBARS increased significantly (P<0.05) while AOP decreased significantly (P<0.05) in the CE group compared with the C group. GSH-Px activity was significantly (P<0.05) lower in the CE group and higher in the melatonin group than the control group. Histopathological changes were found in the kidney tissue of rats treated with CE. These were infiltration in mononuclear cells at perivascular and peritubular areas, hydropic degenerations in tubule epithelium and glomerular sclerosis. The severity of the lesions was reduced by administration of vitamins and melatonin. These results suggest that CE increases lipid peroxidation and decreases AOP by increasing oxidative stress, and that high doses of melatonin and a combination of vitamin E plus vitamin C considerably reduce the toxic effect of CE on kidney tissue of rats.</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1191/0960327102ht225oa</identifier><identifier>PMID: 12099624</identifier><language>eng</language><publisher>England: Sage Publications Ltd</publisher><subject>Animals ; Antioxidants ; Antioxidants - pharmacology ; Ascorbic Acid - pharmacology ; Biochemistry ; Catalase - metabolism ; Drug dosages ; Drug Interactions ; Enzymes ; Glutathione Peroxidase - metabolism ; Kidney - drug effects ; Kidney - pathology ; Lipid peroxidation ; Lipid Peroxidation - drug effects ; Lipids ; Male ; Medicine ; Melatonin ; Melatonin - pharmacology ; Organothiophosphorus Compounds - administration & dosage ; Organothiophosphorus Compounds - toxicity ; Oxidative stress ; Oxidative Stress - drug effects ; Rats ; Rats, Wistar ; Superoxide Dismutase - metabolism ; Thiobarbituric Acid Reactive Substances - metabolism ; Toxicity ; Toxicity Tests ; Toxicology ; Vitamin C ; Vitamin E ; Vitamin E - pharmacology</subject><ispartof>Human & experimental toxicology, 2002-04, Vol.21 (4), p.223-230</ispartof><rights>2002 Arnold</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12099624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oncu, M</creatorcontrib><creatorcontrib>Gultekin, F</creatorcontrib><creatorcontrib>Karaöz, E</creatorcontrib><creatorcontrib>Altuntas, I</creatorcontrib><creatorcontrib>Delibas, N</creatorcontrib><title>Nephrotoxicity in rats induced by chlorpryfos-ethyl and ameliorating effects of antioxidants</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>Nephrotoxicity induced by chlorpyrifos-ethyl (CE) and ameliorating effects of melatonin and vitamin E plus vitamin C were evaluated in rats exposed to CE. Experimental groups were as follows: control (C), CE treated (CE), vitamin E plus vitamin C treated (Vit), melatonin treated (Mel), vitamin E plus vitamin C plus CE treated (Vit+CE), and melatonin plus CE treated (Mel+CE). The rats in the CE, Vit+CE and Mel+CE groups were administered orally with CE in two equal doses of 41 mg/kg body weight (0.25 LD50). Melatonin and vitamins E and C were administrated intramuscularly at the doses of 10, 150 and 200 mg/kg, respectively. The levels of thiobarbituric acid reactive substance (TBARS) and antioxidant potential (AOP), and the activities of glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD) were studied in the homogenates of kidney tissue. There were no significant differences in the activities of SOD and CAT between the experimental groups. The level of TBARS increased significantly (P<0.05) while AOP decreased significantly (P<0.05) in the CE group compared with the C group. GSH-Px activity was significantly (P<0.05) lower in the CE group and higher in the melatonin group than the control group. Histopathological changes were found in the kidney tissue of rats treated with CE. These were infiltration in mononuclear cells at perivascular and peritubular areas, hydropic degenerations in tubule epithelium and glomerular sclerosis. The severity of the lesions was reduced by administration of vitamins and melatonin. These results suggest that CE increases lipid peroxidation and decreases AOP by increasing oxidative stress, and that high doses of melatonin and a combination of vitamin E plus vitamin C considerably reduce the toxic effect of CE on kidney tissue of rats.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Ascorbic Acid - pharmacology</subject><subject>Biochemistry</subject><subject>Catalase - metabolism</subject><subject>Drug dosages</subject><subject>Drug Interactions</subject><subject>Enzymes</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipids</subject><subject>Male</subject><subject>Medicine</subject><subject>Melatonin</subject><subject>Melatonin - pharmacology</subject><subject>Organothiophosphorus Compounds - administration & dosage</subject><subject>Organothiophosphorus Compounds - toxicity</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Toxicity</subject><subject>Toxicity Tests</subject><subject>Toxicology</subject><subject>Vitamin C</subject><subject>Vitamin E</subject><subject>Vitamin E - pharmacology</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkDtPxDAQhC0E4o6DH0CDIgq6gF9J7BIhXtIJGuiQIsfeEJ9ycbAdifx7fOJoqKaYb2d3FqFzgq8JkeQGyxIzWhFMu0hp4dQBWhJeVTmWmB2i5c7Pd8ACnYSwwRiXsiDHaEEolrKkfIk-XmDsvIvu22ob58wOmVcxJDWTBpM1c6a73vnRz60LOcRu7jM1mExtobcusXb4zKBtQacp1yYv2hRmkoZTdNSqPsDZXlfo_eH-7e4pX78-Pt_drvORlkXMCS8k16phjDPcFiUXDaegRVXpAqSCUhHdpKbGCFbRhgPXbVlRQYAL2hjOVujqN3f07muCEOutDRr6Xg3gplATwTkTmCbw8h-4cZMf0m01pVikzZIl6GIPTc0WTD16u1V-rv-exn4ABQZwGw</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Oncu, M</creator><creator>Gultekin, F</creator><creator>Karaöz, E</creator><creator>Altuntas, I</creator><creator>Delibas, N</creator><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>SOI</scope></search><sort><creationdate>20020401</creationdate><title>Nephrotoxicity in rats induced by chlorpryfos-ethyl and ameliorating effects of antioxidants</title><author>Oncu, M ; Gultekin, F ; Karaöz, E ; Altuntas, I ; Delibas, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p265t-14594cab33430f5648b42ec877c5e9ae6a1cb603dd8372b4e4cf67281e482bd43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Ascorbic Acid - pharmacology</topic><topic>Biochemistry</topic><topic>Catalase - metabolism</topic><topic>Drug dosages</topic><topic>Drug Interactions</topic><topic>Enzymes</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Lipid peroxidation</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipids</topic><topic>Male</topic><topic>Medicine</topic><topic>Melatonin</topic><topic>Melatonin - pharmacology</topic><topic>Organothiophosphorus Compounds - administration & dosage</topic><topic>Organothiophosphorus Compounds - toxicity</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Toxicity</topic><topic>Toxicity Tests</topic><topic>Toxicology</topic><topic>Vitamin C</topic><topic>Vitamin E</topic><topic>Vitamin E - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oncu, M</creatorcontrib><creatorcontrib>Gultekin, F</creatorcontrib><creatorcontrib>Karaöz, E</creatorcontrib><creatorcontrib>Altuntas, I</creatorcontrib><creatorcontrib>Delibas, N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environment Abstracts</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oncu, M</au><au>Gultekin, F</au><au>Karaöz, E</au><au>Altuntas, I</au><au>Delibas, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nephrotoxicity in rats induced by chlorpryfos-ethyl and ameliorating effects of antioxidants</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>21</volume><issue>4</issue><spage>223</spage><epage>230</epage><pages>223-230</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>Nephrotoxicity induced by chlorpyrifos-ethyl (CE) and ameliorating effects of melatonin and vitamin E plus vitamin C were evaluated in rats exposed to CE. Experimental groups were as follows: control (C), CE treated (CE), vitamin E plus vitamin C treated (Vit), melatonin treated (Mel), vitamin E plus vitamin C plus CE treated (Vit+CE), and melatonin plus CE treated (Mel+CE). The rats in the CE, Vit+CE and Mel+CE groups were administered orally with CE in two equal doses of 41 mg/kg body weight (0.25 LD50). Melatonin and vitamins E and C were administrated intramuscularly at the doses of 10, 150 and 200 mg/kg, respectively. The levels of thiobarbituric acid reactive substance (TBARS) and antioxidant potential (AOP), and the activities of glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD) were studied in the homogenates of kidney tissue. There were no significant differences in the activities of SOD and CAT between the experimental groups. The level of TBARS increased significantly (P<0.05) while AOP decreased significantly (P<0.05) in the CE group compared with the C group. GSH-Px activity was significantly (P<0.05) lower in the CE group and higher in the melatonin group than the control group. Histopathological changes were found in the kidney tissue of rats treated with CE. These were infiltration in mononuclear cells at perivascular and peritubular areas, hydropic degenerations in tubule epithelium and glomerular sclerosis. The severity of the lesions was reduced by administration of vitamins and melatonin. These results suggest that CE increases lipid peroxidation and decreases AOP by increasing oxidative stress, and that high doses of melatonin and a combination of vitamin E plus vitamin C considerably reduce the toxic effect of CE on kidney tissue of rats.</abstract><cop>England</cop><pub>Sage Publications Ltd</pub><pmid>12099624</pmid><doi>10.1191/0960327102ht225oa</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Antioxidants Antioxidants - pharmacology Ascorbic Acid - pharmacology Biochemistry Catalase - metabolism Drug dosages Drug Interactions Enzymes Glutathione Peroxidase - metabolism Kidney - drug effects Kidney - pathology Lipid peroxidation Lipid Peroxidation - drug effects Lipids Male Medicine Melatonin Melatonin - pharmacology Organothiophosphorus Compounds - administration & dosage Organothiophosphorus Compounds - toxicity Oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar Superoxide Dismutase - metabolism Thiobarbituric Acid Reactive Substances - metabolism Toxicity Toxicity Tests Toxicology Vitamin C Vitamin E Vitamin E - pharmacology |
| title | Nephrotoxicity in rats induced by chlorpryfos-ethyl and ameliorating effects of antioxidants |
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