Simultaneous Real-Time Imaging of Leading and Lagging Strand Synthesis Reveals the Coordination Dynamics of Single Replisomes

The molecular machinery responsible for DNA replication, the replisome, must efficiently coordinate DNA unwinding with priming and synthesis to complete duplication of both strands. Due to the anti-parallel nature of DNA, the leading strand is copied continuously, while the lagging strand is produce...

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Veröffentlicht in:	Molecular cell 2016-12, Vol.64 (6), p.1035-1047
Hauptverfasser:	Duderstadt, Karl E., Geertsema, Hylkje J., Stratmann, Sarah A., Punter, Christiaan M., Kulczyk, Arkadiusz W., Richardson, Charles C., van Oijen, Antoine M.
Format:	Artikel
Sprache:	eng
Schlagworte:	bacteriophage T7 Bacteriophage T7 - genetics Bacteriophage T7 - metabolism Bacteriophage T7 - ultrastructure DNA - biosynthesis DNA - genetics DNA Primase - genetics DNA Primase - metabolism DNA Primase - ultrastructure DNA Replication DNA, Viral - genetics DNA, Viral - metabolism DNA, Viral - ultrastructure flow stretching Kinetics single molecule Single Molecule Imaging - methods Time-Lapse Imaging - methods
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