l -Methionine and silymarin: A comparison of prophylactic protective capabilities in acetaminophen-induced injuries of the liver, kidney and cerebral cortex

Abstract We compared the relative protective abilities of silymarin and l -methionine pre-treatment in acetaminophen overdose injuries of the liver, kidney and cerebral cortex by assessing behaviours, antioxidant status, tissue histological changes and biochemical parameters of hepatic/renal functio...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-01, Vol.85, p.323-333
Hauptverfasser:	Onaolapo, Olakunle J, Adekola, Moses A, Azeez, Taiwo O, Salami, Karimat, Onaolapo, Adejoke Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Animals Antioxidant Antioxidants - pharmacology Anxiety - chemically induced Anxiety - metabolism Anxiety - prevention & control Behavior, Animal - drug effects Biomarkers - metabolism Brain Diseases - chemically induced Brain Diseases - metabolism Brain Diseases - pathology Brain Diseases - prevention & control Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cerebral Cortex - pathology Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Cytoprotection Disease Models, Animal Dose-Response Relationship, Drug Drug overdose Grooming - drug effects Internal Medicine Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Diseases - prevention & control l-Methionine Liver - drug effects Liver - metabolism Liver - pathology Medical Education Memory, Short-Term - drug effects Methionine - pharmacology Motor Activity - drug effects Organ Specificity Oxidative stress Oxidative Stress - drug effects Rats, Wistar Silymarin Silymarin - pharmacology Spatial Memory - drug effects Time Factors Weight Gain - drug effects
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