Mucinous adenocarcinoma arising from a residual supratentorial neurenteric cyst and expressing mutated KRAS : a case report
Malignant transformation of intracranial neurenteric cysts (NCs) has been reported in only 7 cases, but the molecular characteristics leading to malignant transformation remain unclear. A 61-year-old female presented with headache and dizziness. Imaging revealed a 10-cm, extra-axial cystic mass in b...
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| Veröffentlicht in: | Human pathology 2016-12, Vol.58, p.146-151 |
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| creator | Rim, Hyun Taek, MD Song, Joon Ho, MD, PhD Kim, Eun Soo, MD, PhD Kwon, Mi Jung, MD, PhD |
| description | Malignant transformation of intracranial neurenteric cysts (NCs) has been reported in only 7 cases, but the molecular characteristics leading to malignant transformation remain unclear. A 61-year-old female presented with headache and dizziness. Imaging revealed a 10-cm, extra-axial cystic mass in both middle fossae. A partial resection was performed, and the residual mass size gradually decreased. She had repeated ventriculoperitoneal shunts to relieve symptoms of hydrocephalus. Eight years later, follow-up images revealed marked enlargement of the mass and a newly developed lesion. After a second partial resection, a mucinous adenocarcinoma infiltrating the brain was identified. Transitions from benign-looking cuboidal cells to dysplastic cells were observed. A KRAS mutation, which might be associated with malignant NC transformation and was not present in the initial specimen, was identified in the adenocarcinoma. In conclusion, KRAS -mutant mucinous adenocarcinoma may arise in a longstanding residual NC after partial resection. |
| doi_str_mv | 10.1016/j.humpath.2016.05.027 |
| format | Article |
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A 61-year-old female presented with headache and dizziness. Imaging revealed a 10-cm, extra-axial cystic mass in both middle fossae. A partial resection was performed, and the residual mass size gradually decreased. She had repeated ventriculoperitoneal shunts to relieve symptoms of hydrocephalus. Eight years later, follow-up images revealed marked enlargement of the mass and a newly developed lesion. After a second partial resection, a mucinous adenocarcinoma infiltrating the brain was identified. Transitions from benign-looking cuboidal cells to dysplastic cells were observed. A KRAS mutation, which might be associated with malignant NC transformation and was not present in the initial specimen, was identified in the adenocarcinoma. In conclusion, KRAS -mutant mucinous adenocarcinoma may arise in a longstanding residual NC after partial resection.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2016.05.027</identifier><identifier>PMID: 27569299</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adenocarcinoma ; Adenocarcinoma, Mucinous - chemistry ; Adenocarcinoma, Mucinous - genetics ; Adenocarcinoma, Mucinous - pathology ; Adenocarcinoma, Mucinous - surgery ; Antigens ; Biomarkers ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - genetics ; Cell Transformation, Neoplastic - chemistry ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - pathology ; Cysts ; Deoxyribonucleic acid ; DNA ; DNA Mutational Analysis ; Female ; Humans ; Immunohistochemistry ; KRAS ; Magnetic Resonance Imaging ; Metastasis ; Middle Aged ; Mutation ; Neural Tube Defects - pathology ; Neural Tube Defects - surgery ; Neurenteric cyst ; NMR ; Nuclear magnetic resonance ; Pathology ; Proto-Oncogene Proteins p21(ras) - genetics ; Radiation therapy ; Recurrence ; Supratentorial Neoplasms - chemistry ; Supratentorial Neoplasms - genetics ; Supratentorial Neoplasms - pathology ; Supratentorial Neoplasms - surgery ; Surgery ; Time Factors</subject><ispartof>Human pathology, 2016-12, Vol.58, p.146-151</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Dec 01, 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-c14768fa73c95bccc9302c69d8a3aa9d452acdc57248bfe322d4c728fa8914283</citedby><cites>FETCH-LOGICAL-c518t-c14768fa73c95bccc9302c69d8a3aa9d452acdc57248bfe322d4c728fa8914283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humpath.2016.05.027$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27569299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rim, Hyun Taek, MD</creatorcontrib><creatorcontrib>Song, Joon Ho, MD, PhD</creatorcontrib><creatorcontrib>Kim, Eun Soo, MD, PhD</creatorcontrib><creatorcontrib>Kwon, Mi Jung, MD, PhD</creatorcontrib><title>Mucinous adenocarcinoma arising from a residual supratentorial neurenteric cyst and expressing mutated KRAS : a case report</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Malignant transformation of intracranial neurenteric cysts (NCs) has been reported in only 7 cases, but the molecular characteristics leading to malignant transformation remain unclear. A 61-year-old female presented with headache and dizziness. Imaging revealed a 10-cm, extra-axial cystic mass in both middle fossae. A partial resection was performed, and the residual mass size gradually decreased. She had repeated ventriculoperitoneal shunts to relieve symptoms of hydrocephalus. Eight years later, follow-up images revealed marked enlargement of the mass and a newly developed lesion. After a second partial resection, a mucinous adenocarcinoma infiltrating the brain was identified. Transitions from benign-looking cuboidal cells to dysplastic cells were observed. A KRAS mutation, which might be associated with malignant NC transformation and was not present in the initial specimen, was identified in the adenocarcinoma. In conclusion, KRAS -mutant mucinous adenocarcinoma may arise in a longstanding residual NC after partial resection.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma, Mucinous - chemistry</subject><subject>Adenocarcinoma, Mucinous - genetics</subject><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Adenocarcinoma, Mucinous - surgery</subject><subject>Antigens</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Cell Transformation, Neoplastic - chemistry</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Cysts</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Mutational Analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>KRAS</subject><subject>Magnetic Resonance Imaging</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Neural Tube Defects - pathology</subject><subject>Neural Tube Defects - surgery</subject><subject>Neurenteric cyst</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pathology</subject><subject>Proto-Oncogene Proteins p21(ras) - genetics</subject><subject>Radiation therapy</subject><subject>Recurrence</subject><subject>Supratentorial Neoplasms - chemistry</subject><subject>Supratentorial Neoplasms - genetics</subject><subject>Supratentorial Neoplasms - pathology</subject><subject>Supratentorial Neoplasms - surgery</subject><subject>Surgery</subject><subject>Time Factors</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktv1DAUhSMEokPhJ4AssWGT4GceLEBVRQFRhERhbXmub6iHxAl2jBjx5-swA0jdsLKO9J1jX59bFI8ZrRhl9fNddZ3G2SzXFc-yoqqivLlTbJgSvGxFx-8WG0plXbasaU6KBzHuKGVMSXW_OOGNqjvedZvi14cEzk8pEmPRT2DCKkdDTHDR-a-kD9NIDAkYnU1mIDHNwSzolym4LD2mkAUGBwT2cSHGW4I_58z_to9pybQl7z-dXZEXOQhMxJw2T2F5WNzrzRDx0fE8Lb5cvP58_ra8_Pjm3fnZZQmKtUsJTDZ125tGQKe2ANAJyqHubGuEMZ2VihuwoBou222PgnMroeHZ0XZM8lacFs8OuXOYvieMix5dBBwG4zFPrlkrpVCirlf06S10N6Xg8-tWqpGSUaUypQ4UhCnGgL2egxtN2GtG9dqO3uljO3ptR1OlczvZ9-SYnrYj2r-uP3Vk4NUBwPwdPxwGHcGhB7QuICzaTu6_V7y8lQCD8w7M8A33GP9NoyPXVF-tK7JuCKsFZV1enhuriLnQ</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Rim, Hyun Taek, MD</creator><creator>Song, Joon Ho, MD, PhD</creator><creator>Kim, Eun Soo, MD, PhD</creator><creator>Kwon, Mi Jung, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Mucinous adenocarcinoma arising from a residual supratentorial neurenteric cyst and expressing mutated KRAS : a case report</title><author>Rim, Hyun Taek, MD ; Song, Joon Ho, MD, PhD ; Kim, Eun Soo, MD, PhD ; Kwon, Mi Jung, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-c14768fa73c95bccc9302c69d8a3aa9d452acdc57248bfe322d4c728fa8914283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma, Mucinous - chemistry</topic><topic>Adenocarcinoma, Mucinous - genetics</topic><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Adenocarcinoma, Mucinous - surgery</topic><topic>Antigens</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Cell Transformation, Neoplastic - chemistry</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Cysts</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Mutational Analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>KRAS</topic><topic>Magnetic Resonance Imaging</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Neural Tube Defects - pathology</topic><topic>Neural Tube Defects - surgery</topic><topic>Neurenteric cyst</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pathology</topic><topic>Proto-Oncogene Proteins p21(ras) - genetics</topic><topic>Radiation therapy</topic><topic>Recurrence</topic><topic>Supratentorial Neoplasms - chemistry</topic><topic>Supratentorial Neoplasms - genetics</topic><topic>Supratentorial Neoplasms - pathology</topic><topic>Supratentorial Neoplasms - surgery</topic><topic>Surgery</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rim, Hyun Taek, MD</creatorcontrib><creatorcontrib>Song, Joon Ho, MD, PhD</creatorcontrib><creatorcontrib>Kim, Eun Soo, MD, PhD</creatorcontrib><creatorcontrib>Kwon, Mi Jung, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rim, Hyun Taek, MD</au><au>Song, Joon Ho, MD, PhD</au><au>Kim, Eun Soo, MD, PhD</au><au>Kwon, Mi Jung, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucinous adenocarcinoma arising from a residual supratentorial neurenteric cyst and expressing mutated KRAS : a case report</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>58</volume><spage>146</spage><epage>151</epage><pages>146-151</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><abstract>Malignant transformation of intracranial neurenteric cysts (NCs) has been reported in only 7 cases, but the molecular characteristics leading to malignant transformation remain unclear. A 61-year-old female presented with headache and dizziness. Imaging revealed a 10-cm, extra-axial cystic mass in both middle fossae. A partial resection was performed, and the residual mass size gradually decreased. She had repeated ventriculoperitoneal shunts to relieve symptoms of hydrocephalus. Eight years later, follow-up images revealed marked enlargement of the mass and a newly developed lesion. After a second partial resection, a mucinous adenocarcinoma infiltrating the brain was identified. Transitions from benign-looking cuboidal cells to dysplastic cells were observed. A KRAS mutation, which might be associated with malignant NC transformation and was not present in the initial specimen, was identified in the adenocarcinoma. In conclusion, KRAS -mutant mucinous adenocarcinoma may arise in a longstanding residual NC after partial resection.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27569299</pmid><doi>10.1016/j.humpath.2016.05.027</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenocarcinoma Adenocarcinoma, Mucinous - chemistry Adenocarcinoma, Mucinous - genetics Adenocarcinoma, Mucinous - pathology Adenocarcinoma, Mucinous - surgery Antigens Biomarkers Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Cell Transformation, Neoplastic - chemistry Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Cysts Deoxyribonucleic acid DNA DNA Mutational Analysis Female Humans Immunohistochemistry KRAS Magnetic Resonance Imaging Metastasis Middle Aged Mutation Neural Tube Defects - pathology Neural Tube Defects - surgery Neurenteric cyst NMR Nuclear magnetic resonance Pathology Proto-Oncogene Proteins p21(ras) - genetics Radiation therapy Recurrence Supratentorial Neoplasms - chemistry Supratentorial Neoplasms - genetics Supratentorial Neoplasms - pathology Supratentorial Neoplasms - surgery Surgery Time Factors |
| title | Mucinous adenocarcinoma arising from a residual supratentorial neurenteric cyst and expressing mutated KRAS : a case report |
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