Early hippocampal hyperexcitability in PS2APP mice: role of mutant PS2 and APP

Alterations of brain network activity are observable in Alzheimer's disease (AD) together with the occurrence of mild cognitive impairment, before overt pathology. However, in humans as well in AD mouse models, identification of early biomarkers of network dysfunction is still at its beginning....

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Veröffentlicht in:	Neurobiology of aging 2017-02, Vol.50, p.64-76
Hauptverfasser:	Fontana, Roberto, Agostini, Mario, Murana, Emanuele, Mahmud, Mufti, Scremin, Elena, Rubega, Maria, Sparacino, Giovanni, Vassanelli, Stefano, Fasolato, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Alzheimer Disease - physiopathology Alzheimer Disease - psychology Alzheimer's disease Amyloid beta Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Cognition Cognitive Dysfunction - physiopathology Dentate gyrus Dentate Gyrus - physiopathology Disease Models, Animal Female Hippocampus - physiopathology Humans Hyperexcitability Local field potential Mice, Inbred C57BL Mice, Transgenic Mutation Presenilin-2 - genetics Presenilin-2 - metabolism PS2APP
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