Antiviral activities of selected antimalarials against dengue virus type 2 and Zika virus

In a previous study, twelve antimalarial compounds, amodiaquine (AQ) and derivatives, were shown to have potent anti-dengue viral (DENV) activity by using the stable DENV2 Renilla luciferase reporter replicon expressing BHK-21 cells, infectivity (plaque), and the qRT-PCR assays. In this study, we pe...

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Veröffentlicht in:	Antiviral research 2017-01, Vol.137, p.141-150
Hauptverfasser:	Balasubramanian, Anuradha, Teramoto, Tadahisa, Kulkarni, Amol A., Bhattacharjee, Apurba K., Padmanabhan, Radhakrishnan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amodiaquine - analogs & derivatives Amodiaquine - chemistry Amodiaquine - pharmacology Antimalarials - chemistry Antimalarials - pharmacology Antiviral Agents - pharmacology Autophagy Autophagy - drug effects Cathepsin B Computer Simulation Dengue Virus - drug effects Dengue Virus - physiology Drug Discovery Humans In silico modeling Mefloquine - chemistry Mefloquine - pharmacology Molecular electrostatic potentials (MEPs) Quinacrine - chemistry Quinacrine - pharmacology Renilla luciferase reporter replicon Replicon - drug effects Stereo-electronic profiles Virus Replication - drug effects Zika Virus - drug effects Zika Virus - physiology
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