Three-Generation Reproductive Toxicity Study of Dietary Bisphenol A in CD Sprague-Dawley Rats

Bisphenol A (BPA) was evaluated at concentrations of 0, 0.015, 0.3, 4.5, 75, 750, and 7500 ppm (∼ 0.001, 0.02, 0.3, 5, 50, and 500 mg/kg/day of BPA) administered in the diet ad libitum to 30 CD® Sprague-Dawley rats/sex/dose for 3 offspring generations, 1 litter/generation, through F3 adults. Adult s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicological sciences 2002-07, Vol.68 (1), p.121-146
Hauptverfasser:	Tyl, R. W., Myers, C. B., Marr, M. C., Thomas, B. F., Keimowitz, A. R., Brine, D. R., Veselica, M. M., Fail, P. A., Chang, T. Y., Seely, J. C., Joiner, R. L., Butala, J. H., Dimond, S. S., Cagen, S. Z., Shiotsuka, R. N., Stropp, G. D., Waechter, J. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Benzhydryl Compounds Biological and medical sciences Bisphenol A Body Weight - drug effects CAS No. 80-05-7 Chemical and industrial products toxicology. Toxic occupational diseases Diet dietary administration Dose-Response Relationship, Drug Estrogens, Non-Steroidal - administration & dosage Estrogens, Non-Steroidal - toxicity Female Lactation - drug effects Male Medical sciences No-Observed-Adverse-Effect Level OPPTS 837.3800 guidelines Organ Size - drug effects Phenols - administration & dosage Phenols - toxicity postnatal toxicity Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Sprague-Dawley Reproduction - drug effects reproductive toxicity Sexual Maturation - drug effects systemic toxicity Toxicology Various organic compounds
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!