Overcoming the bottleneck of platelet lysate supply in large-scale clinical expansion of adipose-derived stem cells: A comparison of fresh versus three types of platelet lysates from outdated buffy coat–derived platelet concentrates

Abstract Background Platelet lysates (PL) represent a promising replacement for xenogenic growth supplement for adipose-derived stem cell (ASC) expansions. However, fresh platelets from human blood donors are not clinically feasible for large-scale cell expansion based on their limited supply. There...

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Veröffentlicht in:	Cytotherapy (Oxford, England) England), 2017-02, Vol.19 (2), p.222-234
Hauptverfasser:	Glovinski, Peter V, Herly, Mikkel, Mathiasen, Anders B, Svalgaard, Jesper D, Borup, Rehannah, Talman, Maj-Lis M, Elberg, Jens J, Kølle, Stig-Frederik T, Drzewiecki, Krzysztof T, Fischer-Nielsen, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology adipose-derived stem cells Adult Adult Stem Cells - cytology Adult Stem Cells - physiology Advanced Basic Science Blood Buffy Coat - cytology Blood Buffy Coat - transplantation Blood Platelets - chemistry Blood Platelets - cytology Blood Preservation - methods Blood Specimen Collection - methods Cell Culture Techniques - methods Cell Extracts - supply & distribution Cell Proliferation Cell Separation cell therapy Culture Media - metabolism Female Freezing gene expression growth factors Humans Other Plasma - cytology platelet lysate Platelet Transfusion - methods Platelet-Rich Plasma - cytology Refrigeration Time Factors
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