Anti-vascular inflammatory effects of pentacyclic triterpenoids from Astilbe rivularis in vitro and in vivo

Sepsis is a systemic inflammatory condition resulting from bacterial infections. It is associated with high mortality rates, and its therapeutic options are limited. Transforming growth factor β induced protein (TGFBIp) is an extracellular matrix protein that functions as a mediator of experimental...

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Veröffentlicht in:	Chemico-biological interactions 2017-01, Vol.261, p.127-138
Hauptverfasser:	Kang, Hyejin, Ku, Sae-Kwang, Kim, Jongdoo, Chung, Jiwoo, Kim, Sang Chan, Zhou, Wei, Na, MinKyun, Bae, Jong-Sup
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Astilbe rivularis C-27 Carboxylated pentacyclic triterpenoids Cecum - pathology Cell Adhesion - drug effects Cell Adhesion Molecules - metabolism Cell Movement - drug effects Extracellular Matrix Proteins - metabolism Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - pathology Humans Inflammation Inflammation - pathology Interleukin-6 - metabolism Ligation Lipopolysaccharides - pharmacology Lung - drug effects Lung - pathology Male Mice, Inbred C57BL Neutrophils - cytology Neutrophils - drug effects NF-kappa B - metabolism Pentacyclic Triterpenes - chemistry Pentacyclic Triterpenes - pharmacology Pentacyclic Triterpenes - therapeutic use Permeability - drug effects Protective Agents - pharmacology Protective Agents - therapeutic use Punctures Saxifragaceae - chemistry Sepsis Sepsis - drug therapy Sepsis - pathology TGFBIp Transforming Growth Factor beta - metabolism Tumor Necrosis Factor-alpha - metabolism
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