Prevalence of Extracranial Venous Narrowing on Magnetic Resonance Venography is Similar in People With Multiple Sclerosis, Their Siblings, and Unrelated Healthy Controls: A Blinded, Case-Control Study
Abstract Purpose The study sought to assess and compare the prevalence of narrowing of the major extracranial veins in subjects with multiple sclerosis and controls, and to assess the sensitivity and specificity of magnetic resonance venography (MRV) for describing extracranial venous narrowing as i...
Gespeichert in:
| Veröffentlicht in: | Canadian Association of Radiologists journal 2017-05, Vol.68 (2), p.202-209 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 209 |
|---|---|
| container_issue | 2 |
| container_start_page | 202 |
| container_title | Canadian Association of Radiologists journal |
| container_volume | 68 |
| creator | Martin, Nancy, MD, FRCPC Traboulsee, Anthony L., MD, FRCPC Machan, Lindsay, MD, FRCPC, FSIR Klass, Darren, MD, PhD, MRCS, FRCR, FRCPC Ellchuk, Tasha, MD, FRCPC Zhao, Yinshan, PhD Knox, Katherine B., MD, FRCPC Kopriva, David, MDCM, FRCSC Lala, Shantilal, MBBS, FRCPC Nickel, Darren, PhD Otani, Robert, MD, FRCPC Perera, Warren R., MBBS, MMed, FRANZCR Rauscher, Alexander, PhD Sadovnick, A. Dessa, PhD Szkup, Peter, MD, FRCPC, FRCSA, MMed Li, David K., MD, FRCPC |
| description | Abstract Purpose The study sought to assess and compare the prevalence of narrowing of the major extracranial veins in subjects with multiple sclerosis and controls, and to assess the sensitivity and specificity of magnetic resonance venography (MRV) for describing extracranial venous narrowing as it applies to the chronic cerebrospinal venous insufficiency theory, using catheter venography (CV) as the gold standard. Methods The jugular and azygos veins were assessed with time-of-flight MRV in this assessor-blinded, case-control study of subjects with multiple sclerosis, their unaffected siblings, and unrelated controls. The veins were evaluated by diameter and area, and compared with CV. Collateral vessels were also analyzed for maximal diameter, as a potential indicator of compensatory flow. Results A high prevalence of extracranial venous narrowing was demonstrated in all study groups, collectively up to 84% by diameter criteria and 90% by area, with no significant difference between the groups when assessed independently ( P = .34 and .63, respectively). There was high interobserver variability in the reporting of vessel narrowing (kappa = 0.32), and poor vessel per vessel correlation between narrowing on MRV and CV (kappa = 0.064). Collateral neck veins demonstrated no convincing difference in maximum size or correlation with jugular narrowing. Conclusion There is a high prevalence of narrowing of the major extracranial veins on MRV in all 3 study groups, with no significant difference between them. These findings do not support the chronic cerebrospinal venous insufficiency theory. Although MRV has shown a high sensitivity for identifying venous narrowing, time-of-flight imaging demonstrates poor interobserver agreement and poor specificity when compared with the gold standard CV. |
| doi_str_mv | 10.1016/j.carj.2016.07.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1844030457</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1016_j.carj.2016.07.002</sage_id><els_id>S0846537116300833</els_id><sourcerecordid>1964158817</sourcerecordid><originalsourceid>FETCH-LOGICAL-c479t-7cbfa3816900e7b9afa743edbc892b15c8081dd7fe204ae203f5198531d0a113</originalsourceid><addsrcrecordid>eNp9kt9u0zAUxiMEYmXwAlwgS9xwsXR2nMQOQkijGgxpg4kWuLQc-6R1ce1iJ4O-IY-Fo5Y_2sVubB_59322zney7CnBU4JJfbqeKhnW0yKdp5hNMS7uZRNScp4XtCb3swnmZZ1XlJGj7FGMa4xxSVnzMDsqGOesodUk-3Ud4EZacAqQ79D5zz5IFaQz0qIv4PwQ0QcZgv9h3BJ5h67k0kFvFPoE0Ts5ykZsGeR2tUMmornZGCsDMg5dg99aQF9Nv0JXg-3NWM2VheCjiSdosQITkqC1yTzV0mn02QWwsgeNLkDaPnnOvOuDt_ElOkNvEqlBn6CZjJAfbtC8H_TucfagkzbCk8N-nC3eni9mF_nlx3fvZ2eXuSpZ0-dMtZ2knNQNxsDaRnaSlRR0q3hTtKRSHHOiNeugwKVMC-0q0vCKEo0lIfQ4e7G33Qb_fYDYi42JCqyVDlKzBOFliSkuK5bQ57fQtR-CS58TpKlLUnFORqrYUyp1JQboxDaYjQw7QbAYYxZrMcYsxpgFZiLFnETPDtZDuwH9V_In1wSc7oEol_Dfu3dZvtorIDXvxkAQUZlxLLQJoHqhvblb_vqWXKWsjJL2G-wg_vuBiIXAYj6O5jiZpKYYc0rpb7p13zM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1964158817</pqid></control><display><type>article</type><title>Prevalence of Extracranial Venous Narrowing on Magnetic Resonance Venography is Similar in People With Multiple Sclerosis, Their Siblings, and Unrelated Healthy Controls: A Blinded, Case-Control Study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SAGE Complete A-Z List</source><creator>Martin, Nancy, MD, FRCPC ; Traboulsee, Anthony L., MD, FRCPC ; Machan, Lindsay, MD, FRCPC, FSIR ; Klass, Darren, MD, PhD, MRCS, FRCR, FRCPC ; Ellchuk, Tasha, MD, FRCPC ; Zhao, Yinshan, PhD ; Knox, Katherine B., MD, FRCPC ; Kopriva, David, MDCM, FRCSC ; Lala, Shantilal, MBBS, FRCPC ; Nickel, Darren, PhD ; Otani, Robert, MD, FRCPC ; Perera, Warren R., MBBS, MMed, FRANZCR ; Rauscher, Alexander, PhD ; Sadovnick, A. Dessa, PhD ; Szkup, Peter, MD, FRCPC, FRCSA, MMed ; Li, David K., MD, FRCPC</creator><creatorcontrib>Martin, Nancy, MD, FRCPC ; Traboulsee, Anthony L., MD, FRCPC ; Machan, Lindsay, MD, FRCPC, FSIR ; Klass, Darren, MD, PhD, MRCS, FRCR, FRCPC ; Ellchuk, Tasha, MD, FRCPC ; Zhao, Yinshan, PhD ; Knox, Katherine B., MD, FRCPC ; Kopriva, David, MDCM, FRCSC ; Lala, Shantilal, MBBS, FRCPC ; Nickel, Darren, PhD ; Otani, Robert, MD, FRCPC ; Perera, Warren R., MBBS, MMed, FRANZCR ; Rauscher, Alexander, PhD ; Sadovnick, A. Dessa, PhD ; Szkup, Peter, MD, FRCPC, FRCSA, MMed ; Li, David K., MD, FRCPC</creatorcontrib><description>Abstract Purpose The study sought to assess and compare the prevalence of narrowing of the major extracranial veins in subjects with multiple sclerosis and controls, and to assess the sensitivity and specificity of magnetic resonance venography (MRV) for describing extracranial venous narrowing as it applies to the chronic cerebrospinal venous insufficiency theory, using catheter venography (CV) as the gold standard. Methods The jugular and azygos veins were assessed with time-of-flight MRV in this assessor-blinded, case-control study of subjects with multiple sclerosis, their unaffected siblings, and unrelated controls. The veins were evaluated by diameter and area, and compared with CV. Collateral vessels were also analyzed for maximal diameter, as a potential indicator of compensatory flow. Results A high prevalence of extracranial venous narrowing was demonstrated in all study groups, collectively up to 84% by diameter criteria and 90% by area, with no significant difference between the groups when assessed independently ( P = .34 and .63, respectively). There was high interobserver variability in the reporting of vessel narrowing (kappa = 0.32), and poor vessel per vessel correlation between narrowing on MRV and CV (kappa = 0.064). Collateral neck veins demonstrated no convincing difference in maximum size or correlation with jugular narrowing. Conclusion There is a high prevalence of narrowing of the major extracranial veins on MRV in all 3 study groups, with no significant difference between them. These findings do not support the chronic cerebrospinal venous insufficiency theory. Although MRV has shown a high sensitivity for identifying venous narrowing, time-of-flight imaging demonstrates poor interobserver agreement and poor specificity when compared with the gold standard CV.</description><identifier>ISSN: 0846-5371</identifier><identifier>EISSN: 1488-2361</identifier><identifier>DOI: 10.1016/j.carj.2016.07.002</identifier><identifier>PMID: 27887935</identifier><language>eng</language><publisher>Los Angeles, CA: Elsevier Inc</publisher><subject>Adult ; Aged ; Azygos Vein - diagnostic imaging ; Case-Control Studies ; Chronic cerebrospinal venous insufficiency ; Clinical trials ; Constriction, Pathologic - diagnostic imaging ; Constriction, Pathologic - epidemiology ; Constriction, Pathologic - etiology ; Female ; Humans ; Jugular Veins - diagnostic imaging ; Magnetic resonance ; Magnetic Resonance Imaging ; Magnetic resonance venography ; Male ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis - complications ; NMR ; Nuclear magnetic resonance ; Phlebography - methods ; Prevalence ; Prospective Studies ; Radiology ; Sensitivity and Specificity ; Siblings ; Single-Blind Method ; Time-of-flight ; Venous Insufficiency - etiology ; Young Adult</subject><ispartof>Canadian Association of Radiologists journal, 2017-05, Vol.68 (2), p.202-209</ispartof><rights>Canadian Association of Radiologists</rights><rights>2016 Canadian Association of Radiologists</rights><rights>2017 Canadian Association of Radiologists</rights><rights>Copyright © 2016 Canadian Association of Radiologists. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Canadian Association of Radiologists May 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-7cbfa3816900e7b9afa743edbc892b15c8081dd7fe204ae203f5198531d0a113</citedby><cites>FETCH-LOGICAL-c479t-7cbfa3816900e7b9afa743edbc892b15c8081dd7fe204ae203f5198531d0a113</cites><orcidid>0000-0002-3244-789X ; 0000-0002-0768-6899 ; 0000-0002-1961-8252</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1016/j.carj.2016.07.002$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0846537116300833$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,21799,27903,27904,43600,43601,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27887935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin, Nancy, MD, FRCPC</creatorcontrib><creatorcontrib>Traboulsee, Anthony L., MD, FRCPC</creatorcontrib><creatorcontrib>Machan, Lindsay, MD, FRCPC, FSIR</creatorcontrib><creatorcontrib>Klass, Darren, MD, PhD, MRCS, FRCR, FRCPC</creatorcontrib><creatorcontrib>Ellchuk, Tasha, MD, FRCPC</creatorcontrib><creatorcontrib>Zhao, Yinshan, PhD</creatorcontrib><creatorcontrib>Knox, Katherine B., MD, FRCPC</creatorcontrib><creatorcontrib>Kopriva, David, MDCM, FRCSC</creatorcontrib><creatorcontrib>Lala, Shantilal, MBBS, FRCPC</creatorcontrib><creatorcontrib>Nickel, Darren, PhD</creatorcontrib><creatorcontrib>Otani, Robert, MD, FRCPC</creatorcontrib><creatorcontrib>Perera, Warren R., MBBS, MMed, FRANZCR</creatorcontrib><creatorcontrib>Rauscher, Alexander, PhD</creatorcontrib><creatorcontrib>Sadovnick, A. Dessa, PhD</creatorcontrib><creatorcontrib>Szkup, Peter, MD, FRCPC, FRCSA, MMed</creatorcontrib><creatorcontrib>Li, David K., MD, FRCPC</creatorcontrib><title>Prevalence of Extracranial Venous Narrowing on Magnetic Resonance Venography is Similar in People With Multiple Sclerosis, Their Siblings, and Unrelated Healthy Controls: A Blinded, Case-Control Study</title><title>Canadian Association of Radiologists journal</title><addtitle>Can Assoc Radiol J</addtitle><description>Abstract Purpose The study sought to assess and compare the prevalence of narrowing of the major extracranial veins in subjects with multiple sclerosis and controls, and to assess the sensitivity and specificity of magnetic resonance venography (MRV) for describing extracranial venous narrowing as it applies to the chronic cerebrospinal venous insufficiency theory, using catheter venography (CV) as the gold standard. Methods The jugular and azygos veins were assessed with time-of-flight MRV in this assessor-blinded, case-control study of subjects with multiple sclerosis, their unaffected siblings, and unrelated controls. The veins were evaluated by diameter and area, and compared with CV. Collateral vessels were also analyzed for maximal diameter, as a potential indicator of compensatory flow. Results A high prevalence of extracranial venous narrowing was demonstrated in all study groups, collectively up to 84% by diameter criteria and 90% by area, with no significant difference between the groups when assessed independently ( P = .34 and .63, respectively). There was high interobserver variability in the reporting of vessel narrowing (kappa = 0.32), and poor vessel per vessel correlation between narrowing on MRV and CV (kappa = 0.064). Collateral neck veins demonstrated no convincing difference in maximum size or correlation with jugular narrowing. Conclusion There is a high prevalence of narrowing of the major extracranial veins on MRV in all 3 study groups, with no significant difference between them. These findings do not support the chronic cerebrospinal venous insufficiency theory. Although MRV has shown a high sensitivity for identifying venous narrowing, time-of-flight imaging demonstrates poor interobserver agreement and poor specificity when compared with the gold standard CV.</description><subject>Adult</subject><subject>Aged</subject><subject>Azygos Vein - diagnostic imaging</subject><subject>Case-Control Studies</subject><subject>Chronic cerebrospinal venous insufficiency</subject><subject>Clinical trials</subject><subject>Constriction, Pathologic - diagnostic imaging</subject><subject>Constriction, Pathologic - epidemiology</subject><subject>Constriction, Pathologic - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Jugular Veins - diagnostic imaging</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic resonance venography</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - complications</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Phlebography - methods</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Radiology</subject><subject>Sensitivity and Specificity</subject><subject>Siblings</subject><subject>Single-Blind Method</subject><subject>Time-of-flight</subject><subject>Venous Insufficiency - etiology</subject><subject>Young Adult</subject><issn>0846-5371</issn><issn>1488-2361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt9u0zAUxiMEYmXwAlwgS9xwsXR2nMQOQkijGgxpg4kWuLQc-6R1ce1iJ4O-IY-Fo5Y_2sVubB_59322zney7CnBU4JJfbqeKhnW0yKdp5hNMS7uZRNScp4XtCb3swnmZZ1XlJGj7FGMa4xxSVnzMDsqGOesodUk-3Ud4EZacAqQ79D5zz5IFaQz0qIv4PwQ0QcZgv9h3BJ5h67k0kFvFPoE0Ts5ykZsGeR2tUMmornZGCsDMg5dg99aQF9Nv0JXg-3NWM2VheCjiSdosQITkqC1yTzV0mn02QWwsgeNLkDaPnnOvOuDt_ElOkNvEqlBn6CZjJAfbtC8H_TucfagkzbCk8N-nC3eni9mF_nlx3fvZ2eXuSpZ0-dMtZ2knNQNxsDaRnaSlRR0q3hTtKRSHHOiNeugwKVMC-0q0vCKEo0lIfQ4e7G33Qb_fYDYi42JCqyVDlKzBOFliSkuK5bQ57fQtR-CS58TpKlLUnFORqrYUyp1JQboxDaYjQw7QbAYYxZrMcYsxpgFZiLFnETPDtZDuwH9V_In1wSc7oEol_Dfu3dZvtorIDXvxkAQUZlxLLQJoHqhvblb_vqWXKWsjJL2G-wg_vuBiIXAYj6O5jiZpKYYc0rpb7p13zM</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Martin, Nancy, MD, FRCPC</creator><creator>Traboulsee, Anthony L., MD, FRCPC</creator><creator>Machan, Lindsay, MD, FRCPC, FSIR</creator><creator>Klass, Darren, MD, PhD, MRCS, FRCR, FRCPC</creator><creator>Ellchuk, Tasha, MD, FRCPC</creator><creator>Zhao, Yinshan, PhD</creator><creator>Knox, Katherine B., MD, FRCPC</creator><creator>Kopriva, David, MDCM, FRCSC</creator><creator>Lala, Shantilal, MBBS, FRCPC</creator><creator>Nickel, Darren, PhD</creator><creator>Otani, Robert, MD, FRCPC</creator><creator>Perera, Warren R., MBBS, MMed, FRANZCR</creator><creator>Rauscher, Alexander, PhD</creator><creator>Sadovnick, A. Dessa, PhD</creator><creator>Szkup, Peter, MD, FRCPC, FRCSA, MMed</creator><creator>Li, David K., MD, FRCPC</creator><general>Elsevier Inc</general><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>L7M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3244-789X</orcidid><orcidid>https://orcid.org/0000-0002-0768-6899</orcidid><orcidid>https://orcid.org/0000-0002-1961-8252</orcidid></search><sort><creationdate>20170501</creationdate><title>Prevalence of Extracranial Venous Narrowing on Magnetic Resonance Venography is Similar in People With Multiple Sclerosis, Their Siblings, and Unrelated Healthy Controls: A Blinded, Case-Control Study</title><author>Martin, Nancy, MD, FRCPC ; Traboulsee, Anthony L., MD, FRCPC ; Machan, Lindsay, MD, FRCPC, FSIR ; Klass, Darren, MD, PhD, MRCS, FRCR, FRCPC ; Ellchuk, Tasha, MD, FRCPC ; Zhao, Yinshan, PhD ; Knox, Katherine B., MD, FRCPC ; Kopriva, David, MDCM, FRCSC ; Lala, Shantilal, MBBS, FRCPC ; Nickel, Darren, PhD ; Otani, Robert, MD, FRCPC ; Perera, Warren R., MBBS, MMed, FRANZCR ; Rauscher, Alexander, PhD ; Sadovnick, A. Dessa, PhD ; Szkup, Peter, MD, FRCPC, FRCSA, MMed ; Li, David K., MD, FRCPC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-7cbfa3816900e7b9afa743edbc892b15c8081dd7fe204ae203f5198531d0a113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Azygos Vein - diagnostic imaging</topic><topic>Case-Control Studies</topic><topic>Chronic cerebrospinal venous insufficiency</topic><topic>Clinical trials</topic><topic>Constriction, Pathologic - diagnostic imaging</topic><topic>Constriction, Pathologic - epidemiology</topic><topic>Constriction, Pathologic - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Jugular Veins - diagnostic imaging</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic resonance venography</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - complications</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Phlebography - methods</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Radiology</topic><topic>Sensitivity and Specificity</topic><topic>Siblings</topic><topic>Single-Blind Method</topic><topic>Time-of-flight</topic><topic>Venous Insufficiency - etiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin, Nancy, MD, FRCPC</creatorcontrib><creatorcontrib>Traboulsee, Anthony L., MD, FRCPC</creatorcontrib><creatorcontrib>Machan, Lindsay, MD, FRCPC, FSIR</creatorcontrib><creatorcontrib>Klass, Darren, MD, PhD, MRCS, FRCR, FRCPC</creatorcontrib><creatorcontrib>Ellchuk, Tasha, MD, FRCPC</creatorcontrib><creatorcontrib>Zhao, Yinshan, PhD</creatorcontrib><creatorcontrib>Knox, Katherine B., MD, FRCPC</creatorcontrib><creatorcontrib>Kopriva, David, MDCM, FRCSC</creatorcontrib><creatorcontrib>Lala, Shantilal, MBBS, FRCPC</creatorcontrib><creatorcontrib>Nickel, Darren, PhD</creatorcontrib><creatorcontrib>Otani, Robert, MD, FRCPC</creatorcontrib><creatorcontrib>Perera, Warren R., MBBS, MMed, FRANZCR</creatorcontrib><creatorcontrib>Rauscher, Alexander, PhD</creatorcontrib><creatorcontrib>Sadovnick, A. Dessa, PhD</creatorcontrib><creatorcontrib>Szkup, Peter, MD, FRCPC, FRCSA, MMed</creatorcontrib><creatorcontrib>Li, David K., MD, FRCPC</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Canadian Association of Radiologists journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin, Nancy, MD, FRCPC</au><au>Traboulsee, Anthony L., MD, FRCPC</au><au>Machan, Lindsay, MD, FRCPC, FSIR</au><au>Klass, Darren, MD, PhD, MRCS, FRCR, FRCPC</au><au>Ellchuk, Tasha, MD, FRCPC</au><au>Zhao, Yinshan, PhD</au><au>Knox, Katherine B., MD, FRCPC</au><au>Kopriva, David, MDCM, FRCSC</au><au>Lala, Shantilal, MBBS, FRCPC</au><au>Nickel, Darren, PhD</au><au>Otani, Robert, MD, FRCPC</au><au>Perera, Warren R., MBBS, MMed, FRANZCR</au><au>Rauscher, Alexander, PhD</au><au>Sadovnick, A. Dessa, PhD</au><au>Szkup, Peter, MD, FRCPC, FRCSA, MMed</au><au>Li, David K., MD, FRCPC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of Extracranial Venous Narrowing on Magnetic Resonance Venography is Similar in People With Multiple Sclerosis, Their Siblings, and Unrelated Healthy Controls: A Blinded, Case-Control Study</atitle><jtitle>Canadian Association of Radiologists journal</jtitle><addtitle>Can Assoc Radiol J</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>68</volume><issue>2</issue><spage>202</spage><epage>209</epage><pages>202-209</pages><issn>0846-5371</issn><eissn>1488-2361</eissn><abstract>Abstract Purpose The study sought to assess and compare the prevalence of narrowing of the major extracranial veins in subjects with multiple sclerosis and controls, and to assess the sensitivity and specificity of magnetic resonance venography (MRV) for describing extracranial venous narrowing as it applies to the chronic cerebrospinal venous insufficiency theory, using catheter venography (CV) as the gold standard. Methods The jugular and azygos veins were assessed with time-of-flight MRV in this assessor-blinded, case-control study of subjects with multiple sclerosis, their unaffected siblings, and unrelated controls. The veins were evaluated by diameter and area, and compared with CV. Collateral vessels were also analyzed for maximal diameter, as a potential indicator of compensatory flow. Results A high prevalence of extracranial venous narrowing was demonstrated in all study groups, collectively up to 84% by diameter criteria and 90% by area, with no significant difference between the groups when assessed independently ( P = .34 and .63, respectively). There was high interobserver variability in the reporting of vessel narrowing (kappa = 0.32), and poor vessel per vessel correlation between narrowing on MRV and CV (kappa = 0.064). Collateral neck veins demonstrated no convincing difference in maximum size or correlation with jugular narrowing. Conclusion There is a high prevalence of narrowing of the major extracranial veins on MRV in all 3 study groups, with no significant difference between them. These findings do not support the chronic cerebrospinal venous insufficiency theory. Although MRV has shown a high sensitivity for identifying venous narrowing, time-of-flight imaging demonstrates poor interobserver agreement and poor specificity when compared with the gold standard CV.</abstract><cop>Los Angeles, CA</cop><pub>Elsevier Inc</pub><pmid>27887935</pmid><doi>10.1016/j.carj.2016.07.002</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3244-789X</orcidid><orcidid>https://orcid.org/0000-0002-0768-6899</orcidid><orcidid>https://orcid.org/0000-0002-1961-8252</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0846-5371 |
| ispartof | Canadian Association of Radiologists journal, 2017-05, Vol.68 (2), p.202-209 |
| issn | 0846-5371 1488-2361 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1844030457 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SAGE Complete A-Z List |
| subjects | Adult Aged Azygos Vein - diagnostic imaging Case-Control Studies Chronic cerebrospinal venous insufficiency Clinical trials Constriction, Pathologic - diagnostic imaging Constriction, Pathologic - epidemiology Constriction, Pathologic - etiology Female Humans Jugular Veins - diagnostic imaging Magnetic resonance Magnetic Resonance Imaging Magnetic resonance venography Male Middle Aged Multiple sclerosis Multiple Sclerosis - complications NMR Nuclear magnetic resonance Phlebography - methods Prevalence Prospective Studies Radiology Sensitivity and Specificity Siblings Single-Blind Method Time-of-flight Venous Insufficiency - etiology Young Adult |
| title | Prevalence of Extracranial Venous Narrowing on Magnetic Resonance Venography is Similar in People With Multiple Sclerosis, Their Siblings, and Unrelated Healthy Controls: A Blinded, Case-Control Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T20%3A42%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20of%20Extracranial%20Venous%20Narrowing%20on%20Magnetic%20Resonance%20Venography%20is%20Similar%20in%20People%20With%20Multiple%20Sclerosis,%20Their%20Siblings,%20and%20Unrelated%20Healthy%20Controls:%20A%20Blinded,%20Case-Control%20Study&rft.jtitle=Canadian%20Association%20of%20Radiologists%20journal&rft.au=Martin,%20Nancy,%20MD,%20FRCPC&rft.date=2017-05-01&rft.volume=68&rft.issue=2&rft.spage=202&rft.epage=209&rft.pages=202-209&rft.issn=0846-5371&rft.eissn=1488-2361&rft_id=info:doi/10.1016/j.carj.2016.07.002&rft_dat=%3Cproquest_cross%3E1964158817%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1964158817&rft_id=info:pmid/27887935&rft_sage_id=10.1016_j.carj.2016.07.002&rft_els_id=S0846537116300833&rfr_iscdi=true |