Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections

[Display omitted] The influence of vitamin D3 and its metabolites calcifediol (25(OH)D) and calcitriol on immune regulation and inflammation is well described, and raises the question of potential benefit against bacterial infections. In the current study, 25(OH)D was encapsulated in liposomes to en...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2017-09, Vol.118, p.62-67
Hauptverfasser:	Castoldi, Arianna, Herr, Christian, Niederstraßer, Julia, Labouta, Hagar Ibrahim, Melero, Ana, Gordon, Sarah, Schneider-Daum, Nicole, Bals, Robert, Lehr, Claus-Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Bronchi - cytology Calcifediol Calcifediol - administration & dosage Calcifediol - therapeutic use Cell Line Cystic fibrosis Cystic Fibrosis - drug therapy Cystic Fibrosis - immunology Cystic Fibrosis - microbiology Cytokines - metabolism Epithelial Cells Humans Immunologic Factors - administration & dosage Immunologic Factors - therapeutic use Liposome aerosol Liposomes Mice Nanoparticles - administration & dosage Nanoparticles - chemistry Poorly soluble drugs Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - drug therapy Pseudomonas Infections - microbiology Pulmonary drug delivery Respiratory Tract Infections - drug therapy Respiratory Tract Infections - immunology Respiratory Tract Infections - microbiology
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