Changes in plasma fatty acid composition are associated with improvements in obesity and related metabolic disorders: a therapeutic approach to overweight adolescents
Abstract Background & aims : In recent years, obesity has reached alarming levels among children and adolescents. The study of plasma fatty acid (FA) composition, as a reflection of diet, and its associations with other parameters, that are closely linked to obesity and the cardiometabolic profi...
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creator | Guerendiain, Marcela Montes, Rosa López-Belmonte, Gemma Martín-Matillas, Miguel Castellote, Ana I Martín-Bautista, Elena Martí, Amelia Martínez, JAlfredo Moreno, Luis Garagorri, Jesús M Wärnberg, Julia Caballero, Javier Marcos, Ascensión López-Sabater, M. Carmen, PhD Campoy, Cristina |
description | Abstract Background & aims : In recent years, obesity has reached alarming levels among children and adolescents. The study of plasma fatty acid (FA) composition, as a reflection of diet, and its associations with other parameters, that are closely linked to obesity and the cardiometabolic profile, may be useful for setting nutritional goals for obesity treatment and prevention. This study explored the relationship between plasma FA levels and body fat and cardiometabolic risk markers, in overweight adolescents. Methods A multidisciplinary weight loss program was followed by 127 overweight and obese adolescents aged 12-17 years old. Plasma FA composition, anthropometric indicators of adiposity and biochemical parameters were analyzed at baseline, two months (the end of the intensive intervention phase) and six months (the end of the extensive phase). Results While saturated fatty acid (SFA) and n-6 polyunsaturated fatty acid (PUFA) levels decreased significantly during the intervention, monounsaturated fatty acid (MUFA) and n-3 PUFA showed the opposite trend. The decrease in SFA C14:0 was associated with a reduction in total and LDL cholesterol, apolipoprotein B and insulin. The increase in MUFAs, especially C18:1n-9, was related to a reduction in weight, fat mass, fat mass index and glucose. Regarding PUFAs, changes in the n-3 series were not associated with any of the parameters studied, whereas the reduction in n-6 PUFAs was directly related to weight, fat mass, total and HDL cholesterol, apolipoprotein A1, glucose and insulin, and inversely associated with diastolic blood pressure. The adolescents with greater weight loss presented significant changes in MUFAs, n-6 PUFAs and C14:0. Conclusions Modifications in plasma FA composition were associated with adiposity reduction and cardiometabolic profile improvement in an anti-obesity program aimed at adolescents. The changes observed in FA composition were related to the success of the treatment, since the individuals most affected by these variations were those who presented the greatest weight loss. |
doi_str_mv | 10.1016/j.clnu.2016.11.006 |
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Carmen, PhD ; Campoy, Cristina</creator><creatorcontrib>Guerendiain, Marcela ; Montes, Rosa ; López-Belmonte, Gemma ; Martín-Matillas, Miguel ; Castellote, Ana I ; Martín-Bautista, Elena ; Martí, Amelia ; Martínez, JAlfredo ; Moreno, Luis ; Garagorri, Jesús M ; Wärnberg, Julia ; Caballero, Javier ; Marcos, Ascensión ; López-Sabater, M. Carmen, PhD ; Campoy, Cristina ; EVASYON Study Group</creatorcontrib><description>Abstract Background & aims : In recent years, obesity has reached alarming levels among children and adolescents. The study of plasma fatty acid (FA) composition, as a reflection of diet, and its associations with other parameters, that are closely linked to obesity and the cardiometabolic profile, may be useful for setting nutritional goals for obesity treatment and prevention. This study explored the relationship between plasma FA levels and body fat and cardiometabolic risk markers, in overweight adolescents. Methods A multidisciplinary weight loss program was followed by 127 overweight and obese adolescents aged 12-17 years old. Plasma FA composition, anthropometric indicators of adiposity and biochemical parameters were analyzed at baseline, two months (the end of the intensive intervention phase) and six months (the end of the extensive phase). Results While saturated fatty acid (SFA) and n-6 polyunsaturated fatty acid (PUFA) levels decreased significantly during the intervention, monounsaturated fatty acid (MUFA) and n-3 PUFA showed the opposite trend. The decrease in SFA C14:0 was associated with a reduction in total and LDL cholesterol, apolipoprotein B and insulin. The increase in MUFAs, especially C18:1n-9, was related to a reduction in weight, fat mass, fat mass index and glucose. Regarding PUFAs, changes in the n-3 series were not associated with any of the parameters studied, whereas the reduction in n-6 PUFAs was directly related to weight, fat mass, total and HDL cholesterol, apolipoprotein A1, glucose and insulin, and inversely associated with diastolic blood pressure. The adolescents with greater weight loss presented significant changes in MUFAs, n-6 PUFAs and C14:0. Conclusions Modifications in plasma FA composition were associated with adiposity reduction and cardiometabolic profile improvement in an anti-obesity program aimed at adolescents. The changes observed in FA composition were related to the success of the treatment, since the individuals most affected by these variations were those who presented the greatest weight loss.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2016.11.006</identifier><identifier>PMID: 27887752</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adiposity ; Adolescent ; Cardiometabolic profile ; Child ; Fatty Acids - blood ; Female ; Gastroenterology and Hepatology ; Humans ; Male ; Obese adolescents ; Obesity - blood ; Obesity - epidemiology ; Obesity - therapy ; Plasma fatty acids ; Weight loss ; Weight Loss - physiology ; Weight Reduction Programs</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2018-02, Vol.37 (1), p.149-156</ispartof><rights>Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-fb48c05b08baf7e54b5c21734309eb697a20b717eaeeaedb106bfe2927284933</citedby><cites>FETCH-LOGICAL-c455t-fb48c05b08baf7e54b5c21734309eb697a20b717eaeeaedb106bfe2927284933</cites><orcidid>0000-0002-8670-7044</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clnu.2016.11.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27887752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guerendiain, Marcela</creatorcontrib><creatorcontrib>Montes, Rosa</creatorcontrib><creatorcontrib>López-Belmonte, Gemma</creatorcontrib><creatorcontrib>Martín-Matillas, Miguel</creatorcontrib><creatorcontrib>Castellote, Ana I</creatorcontrib><creatorcontrib>Martín-Bautista, Elena</creatorcontrib><creatorcontrib>Martí, Amelia</creatorcontrib><creatorcontrib>Martínez, JAlfredo</creatorcontrib><creatorcontrib>Moreno, Luis</creatorcontrib><creatorcontrib>Garagorri, Jesús M</creatorcontrib><creatorcontrib>Wärnberg, Julia</creatorcontrib><creatorcontrib>Caballero, Javier</creatorcontrib><creatorcontrib>Marcos, Ascensión</creatorcontrib><creatorcontrib>López-Sabater, M. Carmen, PhD</creatorcontrib><creatorcontrib>Campoy, Cristina</creatorcontrib><creatorcontrib>EVASYON Study Group</creatorcontrib><title>Changes in plasma fatty acid composition are associated with improvements in obesity and related metabolic disorders: a therapeutic approach to overweight adolescents</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>Abstract Background & aims : In recent years, obesity has reached alarming levels among children and adolescents. The study of plasma fatty acid (FA) composition, as a reflection of diet, and its associations with other parameters, that are closely linked to obesity and the cardiometabolic profile, may be useful for setting nutritional goals for obesity treatment and prevention. This study explored the relationship between plasma FA levels and body fat and cardiometabolic risk markers, in overweight adolescents. Methods A multidisciplinary weight loss program was followed by 127 overweight and obese adolescents aged 12-17 years old. Plasma FA composition, anthropometric indicators of adiposity and biochemical parameters were analyzed at baseline, two months (the end of the intensive intervention phase) and six months (the end of the extensive phase). Results While saturated fatty acid (SFA) and n-6 polyunsaturated fatty acid (PUFA) levels decreased significantly during the intervention, monounsaturated fatty acid (MUFA) and n-3 PUFA showed the opposite trend. The decrease in SFA C14:0 was associated with a reduction in total and LDL cholesterol, apolipoprotein B and insulin. The increase in MUFAs, especially C18:1n-9, was related to a reduction in weight, fat mass, fat mass index and glucose. Regarding PUFAs, changes in the n-3 series were not associated with any of the parameters studied, whereas the reduction in n-6 PUFAs was directly related to weight, fat mass, total and HDL cholesterol, apolipoprotein A1, glucose and insulin, and inversely associated with diastolic blood pressure. The adolescents with greater weight loss presented significant changes in MUFAs, n-6 PUFAs and C14:0. Conclusions Modifications in plasma FA composition were associated with adiposity reduction and cardiometabolic profile improvement in an anti-obesity program aimed at adolescents. The changes observed in FA composition were related to the success of the treatment, since the individuals most affected by these variations were those who presented the greatest weight loss.</description><subject>Adiposity</subject><subject>Adolescent</subject><subject>Cardiometabolic profile</subject><subject>Child</subject><subject>Fatty Acids - blood</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Male</subject><subject>Obese adolescents</subject><subject>Obesity - blood</subject><subject>Obesity - epidemiology</subject><subject>Obesity - therapy</subject><subject>Plasma fatty acids</subject><subject>Weight loss</subject><subject>Weight Loss - physiology</subject><subject>Weight Reduction Programs</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks2KFTEQhYMoznX0BVxIlm66TdI_6RYR5OIfDLhw9qGSVM_NtbvTJukZ7gv5nKbnji5cCIEK5JyPSp0i5CVnJWe8fXMszTivpcj3kvOSsfYR2fGmEgXvu-ox2THR8qJpeX1BnsV4ZIw1leyekgshu07KRuzIr_0B5huM1M10GSFOQAdI6UTBOEuNnxYfXXJ-phCQQozeOEho6Z1LB-qmJfhbnHBO9wSvMauzebY04HgvnDCB9qMz1Lrog8UQ31Kg6YABFlxTfoAlY8AcaPI048IduptDomD9iNFs8OfkyQBjxBcP9ZJcf_p4vf9SXH37_HX_4aowddOkYtB1Z1ijWadhkNjUujGCy6quWI-67SUIpiWXCJiP1Zy1ekDRCym6uq-qS_L6jM39_FwxJjW53MA4wox-jYp3dc1E30iepeIsNcHHGHBQS3AThJPiTG3xqKPa4lFbPIpzlePJplcP_FVPaP9a_uSRBe_OAsyfvHUYVDQOZ4PWBTRJWe_-z3__j92MbnYGxh94wnj0a5jz-BRXUSimvm8Lsu0HbyteiQz4DbQpusw</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Guerendiain, Marcela</creator><creator>Montes, Rosa</creator><creator>López-Belmonte, Gemma</creator><creator>Martín-Matillas, Miguel</creator><creator>Castellote, Ana I</creator><creator>Martín-Bautista, Elena</creator><creator>Martí, Amelia</creator><creator>Martínez, JAlfredo</creator><creator>Moreno, Luis</creator><creator>Garagorri, Jesús M</creator><creator>Wärnberg, Julia</creator><creator>Caballero, Javier</creator><creator>Marcos, Ascensión</creator><creator>López-Sabater, M. Carmen, PhD</creator><creator>Campoy, Cristina</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8670-7044</orcidid></search><sort><creationdate>20180201</creationdate><title>Changes in plasma fatty acid composition are associated with improvements in obesity and related metabolic disorders: a therapeutic approach to overweight adolescents</title><author>Guerendiain, Marcela ; Montes, Rosa ; López-Belmonte, Gemma ; Martín-Matillas, Miguel ; Castellote, Ana I ; Martín-Bautista, Elena ; Martí, Amelia ; Martínez, JAlfredo ; Moreno, Luis ; Garagorri, Jesús M ; Wärnberg, Julia ; Caballero, Javier ; Marcos, Ascensión ; López-Sabater, M. Carmen, PhD ; Campoy, Cristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-fb48c05b08baf7e54b5c21734309eb697a20b717eaeeaedb106bfe2927284933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adiposity</topic><topic>Adolescent</topic><topic>Cardiometabolic profile</topic><topic>Child</topic><topic>Fatty Acids - blood</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Humans</topic><topic>Male</topic><topic>Obese adolescents</topic><topic>Obesity - blood</topic><topic>Obesity - epidemiology</topic><topic>Obesity - therapy</topic><topic>Plasma fatty acids</topic><topic>Weight loss</topic><topic>Weight Loss - physiology</topic><topic>Weight Reduction Programs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guerendiain, Marcela</creatorcontrib><creatorcontrib>Montes, Rosa</creatorcontrib><creatorcontrib>López-Belmonte, Gemma</creatorcontrib><creatorcontrib>Martín-Matillas, Miguel</creatorcontrib><creatorcontrib>Castellote, Ana I</creatorcontrib><creatorcontrib>Martín-Bautista, Elena</creatorcontrib><creatorcontrib>Martí, Amelia</creatorcontrib><creatorcontrib>Martínez, JAlfredo</creatorcontrib><creatorcontrib>Moreno, Luis</creatorcontrib><creatorcontrib>Garagorri, Jesús M</creatorcontrib><creatorcontrib>Wärnberg, Julia</creatorcontrib><creatorcontrib>Caballero, Javier</creatorcontrib><creatorcontrib>Marcos, Ascensión</creatorcontrib><creatorcontrib>López-Sabater, M. Carmen, PhD</creatorcontrib><creatorcontrib>Campoy, Cristina</creatorcontrib><creatorcontrib>EVASYON Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guerendiain, Marcela</au><au>Montes, Rosa</au><au>López-Belmonte, Gemma</au><au>Martín-Matillas, Miguel</au><au>Castellote, Ana I</au><au>Martín-Bautista, Elena</au><au>Martí, Amelia</au><au>Martínez, JAlfredo</au><au>Moreno, Luis</au><au>Garagorri, Jesús M</au><au>Wärnberg, Julia</au><au>Caballero, Javier</au><au>Marcos, Ascensión</au><au>López-Sabater, M. Carmen, PhD</au><au>Campoy, Cristina</au><aucorp>EVASYON Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in plasma fatty acid composition are associated with improvements in obesity and related metabolic disorders: a therapeutic approach to overweight adolescents</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>37</volume><issue>1</issue><spage>149</spage><epage>156</epage><pages>149-156</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><abstract>Abstract Background & aims : In recent years, obesity has reached alarming levels among children and adolescents. The study of plasma fatty acid (FA) composition, as a reflection of diet, and its associations with other parameters, that are closely linked to obesity and the cardiometabolic profile, may be useful for setting nutritional goals for obesity treatment and prevention. This study explored the relationship between plasma FA levels and body fat and cardiometabolic risk markers, in overweight adolescents. Methods A multidisciplinary weight loss program was followed by 127 overweight and obese adolescents aged 12-17 years old. Plasma FA composition, anthropometric indicators of adiposity and biochemical parameters were analyzed at baseline, two months (the end of the intensive intervention phase) and six months (the end of the extensive phase). Results While saturated fatty acid (SFA) and n-6 polyunsaturated fatty acid (PUFA) levels decreased significantly during the intervention, monounsaturated fatty acid (MUFA) and n-3 PUFA showed the opposite trend. The decrease in SFA C14:0 was associated with a reduction in total and LDL cholesterol, apolipoprotein B and insulin. The increase in MUFAs, especially C18:1n-9, was related to a reduction in weight, fat mass, fat mass index and glucose. Regarding PUFAs, changes in the n-3 series were not associated with any of the parameters studied, whereas the reduction in n-6 PUFAs was directly related to weight, fat mass, total and HDL cholesterol, apolipoprotein A1, glucose and insulin, and inversely associated with diastolic blood pressure. The adolescents with greater weight loss presented significant changes in MUFAs, n-6 PUFAs and C14:0. Conclusions Modifications in plasma FA composition were associated with adiposity reduction and cardiometabolic profile improvement in an anti-obesity program aimed at adolescents. The changes observed in FA composition were related to the success of the treatment, since the individuals most affected by these variations were those who presented the greatest weight loss.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27887752</pmid><doi>10.1016/j.clnu.2016.11.006</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8670-7044</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adiposity Adolescent Cardiometabolic profile Child Fatty Acids - blood Female Gastroenterology and Hepatology Humans Male Obese adolescents Obesity - blood Obesity - epidemiology Obesity - therapy Plasma fatty acids Weight loss Weight Loss - physiology Weight Reduction Programs |
title | Changes in plasma fatty acid composition are associated with improvements in obesity and related metabolic disorders: a therapeutic approach to overweight adolescents |
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