Leucine-rich repeat–containing G-protein–coupled receptor 5–positive cells in the endometrial stem cell niche

Objective To study, isolate and characterize leucine-rich repeat–containing heterotrimeric guanine nucleotide–binding protein–coupled receptor 5 (LGR5)–positive cells from human endometrium to determine their functional relevance. Design Prospective experimental animal study. Setting University rese...

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Veröffentlicht in:	Fertility and sterility 2017-02, Vol.107 (2), p.510-519.e3
Hauptverfasser:	Cervelló, Irene, Ph.D, Gil-Sanchis, Claudia, Ph.D, Santamaría, Xavier, Ph.D., M.D, Faus, Amparo, B.Sc, Vallvé-Juanico, Julia, Ph.D, Díaz-Gimeno, Patricia, Ph.D, Genolet, Oriana, Ph.D, Pellicer, Antonio, Ph.D., M.D, Simón, Carlos, Ph.D., M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Cell Lineage Cell Separation - methods Cells, Cultured Endometrium - metabolism Endometrium - transplantation Epithelial Cells - metabolism Epithelial Cells - transplantation Female Flow Cytometry Gene Expression Regulation hematopoietic lineage Heterografts human endometrium Humans Internal Medicine Kidney - metabolism Kidney - surgery LGR5 Mice, Inbred NOD Mice, SCID Obstetrics and Gynecology Phenotype Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Somatic stem cells stem cell marker Stem Cell Niche Stem Cell Transplantation Stem Cells - metabolism Stromal Cells - metabolism Stromal Cells - transplantation Transcriptome
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