Effects of flaxseed oil on blood hepcidin and hematologic factors in hemodialysis patients
Introduction: In hemodialysis (HD) patients, one of the common complications is renal anemia. Therefore, the present study was designed to investigate the effects of flaxseed oil consumption on blood hepcidin and hematologic factors in HD patients. Methods: In this randomized, double‐blind, clinical...
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| Veröffentlicht in: | Hemodialysis international 2017-10, Vol.21 (4), p.549-556 |
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| creator | Tabibi, Hadi Mirfatahi, Maryam Hedayati, Mehdi Nasrollahi, Alireza |
| description | Introduction: In hemodialysis (HD) patients, one of the common complications is renal anemia. Therefore, the present study was designed to investigate the effects of flaxseed oil consumption on blood hepcidin and hematologic factors in HD patients.
Methods: In this randomized, double‐blind, clinical trial, 38 HD patients were randomly assigned to either the flaxseed oil or the control group. The patients in the flaxseed oil group received 6 g/d flaxseed oil for 8 wk, whereas the control group received 6 g/d medium chain triglycerides (MCT) oil. At baseline and the end of week 8, serum hepcidin, and blood hemoglobin, hematocrit, red blood cells (RBCs), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were measured after a 12‐ to 14‐h fast.
Findings: Flaxseed oil consumption significantly reduced serum hepcidin concentration up to 25% during 8 weeks, and the reduction was significant in comparison with the MCT oil group. In addition, the number of RBCs, blood hemoglobin, hematocrit, MCH and MCHC increased significantly in the flaxseed oil group up to 6%, 10%, 6%, 5%, and 2%, respectively, and these elevations were significant in comparison with the MCT oil group. There was no significant difference between the two groups in mean changes of MCV.
Discussion: This study indicates that daily consumption of 6 g flaxseed oil reduces serum hepcidin and improves hematologic factors in HD patients. |
| doi_str_mv | 10.1111/hdi.12516 |
| format | Article |
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Methods: In this randomized, double‐blind, clinical trial, 38 HD patients were randomly assigned to either the flaxseed oil or the control group. The patients in the flaxseed oil group received 6 g/d flaxseed oil for 8 wk, whereas the control group received 6 g/d medium chain triglycerides (MCT) oil. At baseline and the end of week 8, serum hepcidin, and blood hemoglobin, hematocrit, red blood cells (RBCs), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were measured after a 12‐ to 14‐h fast.
Findings: Flaxseed oil consumption significantly reduced serum hepcidin concentration up to 25% during 8 weeks, and the reduction was significant in comparison with the MCT oil group. In addition, the number of RBCs, blood hemoglobin, hematocrit, MCH and MCHC increased significantly in the flaxseed oil group up to 6%, 10%, 6%, 5%, and 2%, respectively, and these elevations were significant in comparison with the MCT oil group. There was no significant difference between the two groups in mean changes of MCV.
Discussion: This study indicates that daily consumption of 6 g flaxseed oil reduces serum hepcidin and improves hematologic factors in HD patients.</description><identifier>ISSN: 1492-7535</identifier><identifier>EISSN: 1542-4758</identifier><identifier>DOI: 10.1111/hdi.12516</identifier><identifier>PMID: 27885786</identifier><language>eng</language><publisher>Canada</publisher><subject>Aged ; Anemia - drug therapy ; Double-Blind Method ; Female ; Flaxseed oil ; hematologic factors ; hemodialysis ; hepcidin ; Hepcidins - blood ; Humans ; Linseed Oil - therapeutic use ; Male ; Middle Aged ; renal anemia ; Renal Dialysis - methods</subject><ispartof>Hemodialysis international, 2017-10, Vol.21 (4), p.549-556</ispartof><rights>2016 International Society for Hemodialysis</rights><rights>2016 International Society for Hemodialysis.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3256-ae88c842a4120ed8ee1429976f68d8be3809d6f2ff0c6b3595957d8c176320c3</citedby><cites>FETCH-LOGICAL-c3256-ae88c842a4120ed8ee1429976f68d8be3809d6f2ff0c6b3595957d8c176320c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhdi.12516$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhdi.12516$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27885786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tabibi, Hadi</creatorcontrib><creatorcontrib>Mirfatahi, Maryam</creatorcontrib><creatorcontrib>Hedayati, Mehdi</creatorcontrib><creatorcontrib>Nasrollahi, Alireza</creatorcontrib><title>Effects of flaxseed oil on blood hepcidin and hematologic factors in hemodialysis patients</title><title>Hemodialysis international</title><addtitle>Hemodial Int</addtitle><description>Introduction: In hemodialysis (HD) patients, one of the common complications is renal anemia. Therefore, the present study was designed to investigate the effects of flaxseed oil consumption on blood hepcidin and hematologic factors in HD patients.
Methods: In this randomized, double‐blind, clinical trial, 38 HD patients were randomly assigned to either the flaxseed oil or the control group. The patients in the flaxseed oil group received 6 g/d flaxseed oil for 8 wk, whereas the control group received 6 g/d medium chain triglycerides (MCT) oil. At baseline and the end of week 8, serum hepcidin, and blood hemoglobin, hematocrit, red blood cells (RBCs), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were measured after a 12‐ to 14‐h fast.
Findings: Flaxseed oil consumption significantly reduced serum hepcidin concentration up to 25% during 8 weeks, and the reduction was significant in comparison with the MCT oil group. In addition, the number of RBCs, blood hemoglobin, hematocrit, MCH and MCHC increased significantly in the flaxseed oil group up to 6%, 10%, 6%, 5%, and 2%, respectively, and these elevations were significant in comparison with the MCT oil group. There was no significant difference between the two groups in mean changes of MCV.
Discussion: This study indicates that daily consumption of 6 g flaxseed oil reduces serum hepcidin and improves hematologic factors in HD patients.</description><subject>Aged</subject><subject>Anemia - drug therapy</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Flaxseed oil</subject><subject>hematologic factors</subject><subject>hemodialysis</subject><subject>hepcidin</subject><subject>Hepcidins - blood</subject><subject>Humans</subject><subject>Linseed Oil - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>renal anemia</subject><subject>Renal Dialysis - methods</subject><issn>1492-7535</issn><issn>1542-4758</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOxCAUhonRODq68AUMS13UAQqULs14TUzcuHLTUDgohpaxdKLz9qId3clZcC5fvsWP0AklFzS_xav1F5QJKnfQARWcFbwSajf3vGZFJUoxQ4cpvRHCKCFyH81YpZSolDxAz9fOgRkTjg67oD8TgMXRBxx73IYYLX6FlfHW91j330OnxxjiizfYaTPGIeF8yutovQ6b5BNe6dFDP6YjtOd0SHC8_efo6eb6aXlXPDze3i8vHwpTMiELDUoZxZnmlBGwCoByVteVdFJZ1UKpSG2lY84RI9tS1LkqqwytZMmIKefobNKuhvi-hjQ2nU8GQtA9xHVqqOKcMMkFz-j5hJohpjSAa1aD7_SwaShpvpNscpLNT5KZPd1q120H9o_8jS4Diwn48AE2_5uau6v7SfkFbuh9Ag</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Tabibi, Hadi</creator><creator>Mirfatahi, Maryam</creator><creator>Hedayati, Mehdi</creator><creator>Nasrollahi, Alireza</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>Effects of flaxseed oil on blood hepcidin and hematologic factors in hemodialysis patients</title><author>Tabibi, Hadi ; Mirfatahi, Maryam ; Hedayati, Mehdi ; Nasrollahi, Alireza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3256-ae88c842a4120ed8ee1429976f68d8be3809d6f2ff0c6b3595957d8c176320c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Anemia - drug therapy</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Flaxseed oil</topic><topic>hematologic factors</topic><topic>hemodialysis</topic><topic>hepcidin</topic><topic>Hepcidins - blood</topic><topic>Humans</topic><topic>Linseed Oil - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>renal anemia</topic><topic>Renal Dialysis - methods</topic><toplevel>online_resources</toplevel><creatorcontrib>Tabibi, Hadi</creatorcontrib><creatorcontrib>Mirfatahi, Maryam</creatorcontrib><creatorcontrib>Hedayati, Mehdi</creatorcontrib><creatorcontrib>Nasrollahi, Alireza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hemodialysis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tabibi, Hadi</au><au>Mirfatahi, Maryam</au><au>Hedayati, Mehdi</au><au>Nasrollahi, Alireza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of flaxseed oil on blood hepcidin and hematologic factors in hemodialysis patients</atitle><jtitle>Hemodialysis international</jtitle><addtitle>Hemodial Int</addtitle><date>2017-10</date><risdate>2017</risdate><volume>21</volume><issue>4</issue><spage>549</spage><epage>556</epage><pages>549-556</pages><issn>1492-7535</issn><eissn>1542-4758</eissn><abstract>Introduction: In hemodialysis (HD) patients, one of the common complications is renal anemia. Therefore, the present study was designed to investigate the effects of flaxseed oil consumption on blood hepcidin and hematologic factors in HD patients.
Methods: In this randomized, double‐blind, clinical trial, 38 HD patients were randomly assigned to either the flaxseed oil or the control group. The patients in the flaxseed oil group received 6 g/d flaxseed oil for 8 wk, whereas the control group received 6 g/d medium chain triglycerides (MCT) oil. At baseline and the end of week 8, serum hepcidin, and blood hemoglobin, hematocrit, red blood cells (RBCs), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were measured after a 12‐ to 14‐h fast.
Findings: Flaxseed oil consumption significantly reduced serum hepcidin concentration up to 25% during 8 weeks, and the reduction was significant in comparison with the MCT oil group. In addition, the number of RBCs, blood hemoglobin, hematocrit, MCH and MCHC increased significantly in the flaxseed oil group up to 6%, 10%, 6%, 5%, and 2%, respectively, and these elevations were significant in comparison with the MCT oil group. There was no significant difference between the two groups in mean changes of MCV.
Discussion: This study indicates that daily consumption of 6 g flaxseed oil reduces serum hepcidin and improves hematologic factors in HD patients.</abstract><cop>Canada</cop><pmid>27885786</pmid><doi>10.1111/hdi.12516</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Anemia - drug therapy Double-Blind Method Female Flaxseed oil hematologic factors hemodialysis hepcidin Hepcidins - blood Humans Linseed Oil - therapeutic use Male Middle Aged renal anemia Renal Dialysis - methods |
| title | Effects of flaxseed oil on blood hepcidin and hematologic factors in hemodialysis patients |
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