Conditioned pain modulation and pressure pain sensitivity in the adult Danish general population: The DanFunD study
Abstract Increased pressure pain sensitivity and impaired descending pain control have been associated with chronic pain, but knowledge on the variability in the adult general population is lacking. Pressure pain thresholds (PPTs) and descending pain control as assessed by conditioning pain modulati...
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| Veröffentlicht in: | The journal of pain 2017-03, Vol.18 (3), p.274-284 |
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| creator | Skovbjerg, S Jørgensen, T Arendt-Nielsen, L Ebstrup, J.F Carstensen, T Graven-Nielsen, T |
| description | Abstract Increased pressure pain sensitivity and impaired descending pain control have been associated with chronic pain, but knowledge on the variability in the adult general population is lacking. Pressure pain thresholds (PPTs) and descending pain control as assessed by conditioning pain modulation (CPM) were recorded in a randomly selected sample (n=2199, 53% females) of the Danish adult general population aged 18-70 years. PPTs were recorded over the tibialis anterior muscle and the upper trapezius muscle. CPM was defined as the difference between PPT assessments before and during conditioning with cold pressor pain (hand) for 2 min. Conditioning pain intensity was assessed on a visual analogue scale (VAS) and questionnaire data was collected. Female sex (P |
| doi_str_mv | 10.1016/j.jpain.2016.10.022 |
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Pressure pain thresholds (PPTs) and descending pain control as assessed by conditioning pain modulation (CPM) were recorded in a randomly selected sample (n=2199, 53% females) of the Danish adult general population aged 18-70 years. PPTs were recorded over the tibialis anterior muscle and the upper trapezius muscle. CPM was defined as the difference between PPT assessments before and during conditioning with cold pressor pain (hand) for 2 min. Conditioning pain intensity was assessed on a visual analogue scale (VAS) and questionnaire data was collected. Female sex (P<0.001) and younger age (P≤0.02) was associated with lower PPTs at both body sites. For the trapezius muscle, high perceived stress were associated with lower PPTs (P<0.02), whereas an interaction was found between body mass index and sex. CPM potency was lower in females compared with males (P≤0.003) whereas no association with age was found. Higher education (P≤0.05), premature withdrawal from the cold pressor test (P≤0.02) and high VAS score (P≤0.02) were associated with a larger CPM response. Perspectives Data from this large population-based study provides new insight into the gender and age variation in pain sensitivity and CPM response. Decreased CPM potency and increased pain sensitivity in females were found, emphasizing the need to improve the understanding of its clinical consequences.</description><identifier>ISSN: 1526-5900</identifier><identifier>EISSN: 1528-8447</identifier><identifier>DOI: 10.1016/j.jpain.2016.10.022</identifier><identifier>PMID: 27884690</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Anesthesia & Perioperative Care ; cold pressor test ; Community Health Planning ; Conditioned pain modulation ; Conditioning (Psychology) - physiology ; Denmark - epidemiology ; epidemiology ; Female ; general population ; Humans ; Male ; Middle Aged ; Muscle, Skeletal - innervation ; Pain - epidemiology ; Pain - physiopathology ; Pain - psychology ; Pain Measurement ; Pain Medicine ; Pain Perception - physiology ; Pain Threshold - physiology ; Pressure ; pressure pain thresholds ; Self Report ; Sex Factors ; Statistics, Nonparametric ; Young Adult</subject><ispartof>The journal of pain, 2017-03, Vol.18 (3), p.274-284</ispartof><rights>2016 American Pain Society</rights><rights>Copyright © 2016 American Pain Society. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-4a7dd2a18eab4b3ebfec509969465c3824d573fb8271abca06e03012ff3452a63</citedby><cites>FETCH-LOGICAL-c525t-4a7dd2a18eab4b3ebfec509969465c3824d573fb8271abca06e03012ff3452a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1526590016303157$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27884690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skovbjerg, S</creatorcontrib><creatorcontrib>Jørgensen, T</creatorcontrib><creatorcontrib>Arendt-Nielsen, L</creatorcontrib><creatorcontrib>Ebstrup, J.F</creatorcontrib><creatorcontrib>Carstensen, T</creatorcontrib><creatorcontrib>Graven-Nielsen, T</creatorcontrib><title>Conditioned pain modulation and pressure pain sensitivity in the adult Danish general population: The DanFunD study</title><title>The journal of pain</title><addtitle>J Pain</addtitle><description>Abstract Increased pressure pain sensitivity and impaired descending pain control have been associated with chronic pain, but knowledge on the variability in the adult general population is lacking. Pressure pain thresholds (PPTs) and descending pain control as assessed by conditioning pain modulation (CPM) were recorded in a randomly selected sample (n=2199, 53% females) of the Danish adult general population aged 18-70 years. PPTs were recorded over the tibialis anterior muscle and the upper trapezius muscle. CPM was defined as the difference between PPT assessments before and during conditioning with cold pressor pain (hand) for 2 min. Conditioning pain intensity was assessed on a visual analogue scale (VAS) and questionnaire data was collected. Female sex (P<0.001) and younger age (P≤0.02) was associated with lower PPTs at both body sites. For the trapezius muscle, high perceived stress were associated with lower PPTs (P<0.02), whereas an interaction was found between body mass index and sex. CPM potency was lower in females compared with males (P≤0.003) whereas no association with age was found. Higher education (P≤0.05), premature withdrawal from the cold pressor test (P≤0.02) and high VAS score (P≤0.02) were associated with a larger CPM response. Perspectives Data from this large population-based study provides new insight into the gender and age variation in pain sensitivity and CPM response. Decreased CPM potency and increased pain sensitivity in females were found, emphasizing the need to improve the understanding of its clinical consequences.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Anesthesia & Perioperative Care</subject><subject>cold pressor test</subject><subject>Community Health Planning</subject><subject>Conditioned pain modulation</subject><subject>Conditioning (Psychology) - physiology</subject><subject>Denmark - epidemiology</subject><subject>epidemiology</subject><subject>Female</subject><subject>general population</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - innervation</subject><subject>Pain - epidemiology</subject><subject>Pain - physiopathology</subject><subject>Pain - psychology</subject><subject>Pain Measurement</subject><subject>Pain Medicine</subject><subject>Pain Perception - physiology</subject><subject>Pain Threshold - physiology</subject><subject>Pressure</subject><subject>pressure pain thresholds</subject><subject>Self Report</subject><subject>Sex Factors</subject><subject>Statistics, Nonparametric</subject><subject>Young Adult</subject><issn>1526-5900</issn><issn>1528-8447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAQxy0Eog_4BEjIRy7Z-hHngQQS2j5AqtRDy9ly7Al1yNrBk1Tab4_TXThw4WTPf34zo_kPIe8423DGq4thM0zGh43IQVY2TIgX5JQr0RRNWdYvn_9VoVrGTsgZ4sAY56quX5MTUTdNWbXslOA2BudnHwM4uraju-iW0awKNSFrCRCXBIckQsBMP_l5T3M4PwI1GZ_ppQkeH-kPCJDMSKc4HZt8pA8ZyunrJVxSnBe3f0Ne9WZEeHt8z8n366uH7dfi9u7m2_bLbWGVUHNRmto5YXgDpis7CV0PVrG2rdqyUlY2onSqln3XiJqbzhpWAZOMi76XpRKmkufkw6HvlOKvBXDWO48WxtEEiAtqnm1iQtVtnVF5QG2KiAl6PSW_M2mvOdOr23rQz27r1e1VzG7nqvfHAUu3A_e35o-9Gfh0ACCv-eQhabQeggXnE9hZu-j_M-DzP_V29MFbM_6EPeAQlxSyg5prFJrp-_Xg6715JZnMt5a_AZQaqAM</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Skovbjerg, S</creator><creator>Jørgensen, T</creator><creator>Arendt-Nielsen, L</creator><creator>Ebstrup, J.F</creator><creator>Carstensen, T</creator><creator>Graven-Nielsen, T</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170301</creationdate><title>Conditioned pain modulation and pressure pain sensitivity in the adult Danish general population: The DanFunD study</title><author>Skovbjerg, S ; Jørgensen, T ; Arendt-Nielsen, L ; Ebstrup, J.F ; Carstensen, T ; Graven-Nielsen, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-4a7dd2a18eab4b3ebfec509969465c3824d573fb8271abca06e03012ff3452a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Anesthesia & Perioperative Care</topic><topic>cold pressor test</topic><topic>Community Health Planning</topic><topic>Conditioned pain modulation</topic><topic>Conditioning (Psychology) - physiology</topic><topic>Denmark - epidemiology</topic><topic>epidemiology</topic><topic>Female</topic><topic>general population</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - innervation</topic><topic>Pain - epidemiology</topic><topic>Pain - physiopathology</topic><topic>Pain - psychology</topic><topic>Pain Measurement</topic><topic>Pain Medicine</topic><topic>Pain Perception - physiology</topic><topic>Pain Threshold - physiology</topic><topic>Pressure</topic><topic>pressure pain thresholds</topic><topic>Self Report</topic><topic>Sex Factors</topic><topic>Statistics, Nonparametric</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skovbjerg, S</creatorcontrib><creatorcontrib>Jørgensen, T</creatorcontrib><creatorcontrib>Arendt-Nielsen, L</creatorcontrib><creatorcontrib>Ebstrup, J.F</creatorcontrib><creatorcontrib>Carstensen, T</creatorcontrib><creatorcontrib>Graven-Nielsen, T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of pain</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skovbjerg, S</au><au>Jørgensen, T</au><au>Arendt-Nielsen, L</au><au>Ebstrup, J.F</au><au>Carstensen, T</au><au>Graven-Nielsen, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conditioned pain modulation and pressure pain sensitivity in the adult Danish general population: The DanFunD study</atitle><jtitle>The journal of pain</jtitle><addtitle>J Pain</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>18</volume><issue>3</issue><spage>274</spage><epage>284</epage><pages>274-284</pages><issn>1526-5900</issn><eissn>1528-8447</eissn><abstract>Abstract Increased pressure pain sensitivity and impaired descending pain control have been associated with chronic pain, but knowledge on the variability in the adult general population is lacking. Pressure pain thresholds (PPTs) and descending pain control as assessed by conditioning pain modulation (CPM) were recorded in a randomly selected sample (n=2199, 53% females) of the Danish adult general population aged 18-70 years. PPTs were recorded over the tibialis anterior muscle and the upper trapezius muscle. CPM was defined as the difference between PPT assessments before and during conditioning with cold pressor pain (hand) for 2 min. Conditioning pain intensity was assessed on a visual analogue scale (VAS) and questionnaire data was collected. Female sex (P<0.001) and younger age (P≤0.02) was associated with lower PPTs at both body sites. For the trapezius muscle, high perceived stress were associated with lower PPTs (P<0.02), whereas an interaction was found between body mass index and sex. CPM potency was lower in females compared with males (P≤0.003) whereas no association with age was found. Higher education (P≤0.05), premature withdrawal from the cold pressor test (P≤0.02) and high VAS score (P≤0.02) were associated with a larger CPM response. Perspectives Data from this large population-based study provides new insight into the gender and age variation in pain sensitivity and CPM response. Decreased CPM potency and increased pain sensitivity in females were found, emphasizing the need to improve the understanding of its clinical consequences.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27884690</pmid><doi>10.1016/j.jpain.2016.10.022</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Anesthesia & Perioperative Care cold pressor test Community Health Planning Conditioned pain modulation Conditioning (Psychology) - physiology Denmark - epidemiology epidemiology Female general population Humans Male Middle Aged Muscle, Skeletal - innervation Pain - epidemiology Pain - physiopathology Pain - psychology Pain Measurement Pain Medicine Pain Perception - physiology Pain Threshold - physiology Pressure pressure pain thresholds Self Report Sex Factors Statistics, Nonparametric Young Adult |
| title | Conditioned pain modulation and pressure pain sensitivity in the adult Danish general population: The DanFunD study |
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