Accumulation and Determination of Phenylethanolamine A Residue in Hair of Swine and Sheep
The present study proposed the use of liquid chromatography-tandem mass spectrometry to detect the novel β-agonist phenylethanolamine A (PEA) in incurred hair samples of swine and sheep and to assess its accumulation for residue monitoring. The method showed good percent recoveries ranging from 93.2...
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| Veröffentlicht in: | Journal of analytical toxicology 2017-03, Vol.41 (2), p.146-152 |
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| container_title | Journal of analytical toxicology |
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| creator | Decheng, Suo Ruiguo, Wang Peilong, Wang Genlong, Zhao Yufei, Fan Xia, Fan Yang, Li Xiaoou, Su |
| description | The present study proposed the use of liquid chromatography-tandem mass spectrometry to detect the novel β-agonist phenylethanolamine A (PEA) in incurred hair samples of swine and sheep and to assess its accumulation for residue monitoring. The method showed good percent recoveries ranging from 93.2% to 102% and good coefficient of variation at |
| doi_str_mv | 10.1093/jat/bkw121 |
| format | Article |
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The method showed good percent recoveries ranging from 93.2% to 102% and good coefficient of variation at <15%. The experiment was conducted in swine (24 treated and 4 controls) and sheep (3 treated and 1 control). PEA concentration was determined in hair during the treatment. High residue concentrations were present in hair as early as Day 24 (14.8 ± 3.6 and 25.8 ± 7.6 ng/g) and Day 21 (23.4 ± 6.6 ng/g) for swine and sheep; these residues persisted until withdrawal on Days 14 and 21. Results showed high PEA accumulation in hair, thereby indicating the use of hair as a matrix in the control of PEA abuse in farm animals.</description><identifier>ISSN: 0146-4760</identifier><identifier>EISSN: 1945-2403</identifier><identifier>DOI: 10.1093/jat/bkw121</identifier><identifier>PMID: 27881619</identifier><language>eng</language><publisher>England</publisher><subject>2-Hydroxyphenethylamine - analogs & derivatives ; 2-Hydroxyphenethylamine - analysis ; Adrenergic beta-Agonists - analysis ; Animals ; Chromatography, Liquid ; Drug Residues - analysis ; Female ; Hair - chemistry ; Male ; Sheep ; Substance Abuse Detection - instrumentation ; Substance Abuse Detection - methods ; Substance Abuse Detection - veterinary ; Swine ; Tandem Mass Spectrometry</subject><ispartof>Journal of analytical toxicology, 2017-03, Vol.41 (2), p.146-152</ispartof><rights>The Author 2016. Published by Oxford University Press. All rights reserved. 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The method showed good percent recoveries ranging from 93.2% to 102% and good coefficient of variation at <15%. The experiment was conducted in swine (24 treated and 4 controls) and sheep (3 treated and 1 control). PEA concentration was determined in hair during the treatment. High residue concentrations were present in hair as early as Day 24 (14.8 ± 3.6 and 25.8 ± 7.6 ng/g) and Day 21 (23.4 ± 6.6 ng/g) for swine and sheep; these residues persisted until withdrawal on Days 14 and 21. Results showed high PEA accumulation in hair, thereby indicating the use of hair as a matrix in the control of PEA abuse in farm animals.</description><subject>2-Hydroxyphenethylamine - analogs & derivatives</subject><subject>2-Hydroxyphenethylamine - analysis</subject><subject>Adrenergic beta-Agonists - analysis</subject><subject>Animals</subject><subject>Chromatography, Liquid</subject><subject>Drug Residues - analysis</subject><subject>Female</subject><subject>Hair - chemistry</subject><subject>Male</subject><subject>Sheep</subject><subject>Substance Abuse Detection - instrumentation</subject><subject>Substance Abuse Detection - methods</subject><subject>Substance Abuse Detection - veterinary</subject><subject>Swine</subject><subject>Tandem Mass Spectrometry</subject><issn>0146-4760</issn><issn>1945-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLw0AURgdRbK1u_AGSpQixc2eSSWZZ6qNCQbG6cBVmJndoal5mEkr_vQmpri7c73AWh5BroPdAJZ_vVDvX33tgcEKmIIPQZwHlp2RKIRB-EAk6IRfO7SgFEQt-TiYsimMQIKfka2FMV3S5arOq9FSZeg_YYlNk5fiprPe2xfKQY7tVZZWrfkFv4b2jy9IOvaz0ViprBm6zH6ZBsdki1pfkzKrc4dXxzsjn0-PHcuWvX59flou1bzjjrW9AWQrGWiNYZGRshE6pZlJzzbQVDLWVUqdCUBOFTKOhAYLRIqQYmiBifEZuR2_dVD8dujYpMmcwz1WJVecSiAMuhYSQ9ujdiJqmcq5Bm9RNVqjmkABNhpRJnzIZU_bwzdHb6QLTf_SvHf8Fgsdw6w</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Decheng, Suo</creator><creator>Ruiguo, Wang</creator><creator>Peilong, Wang</creator><creator>Genlong, Zhao</creator><creator>Yufei, Fan</creator><creator>Xia, Fan</creator><creator>Yang, Li</creator><creator>Xiaoou, Su</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170301</creationdate><title>Accumulation and Determination of Phenylethanolamine A Residue in Hair of Swine and Sheep</title><author>Decheng, Suo ; Ruiguo, Wang ; Peilong, Wang ; Genlong, Zhao ; Yufei, Fan ; Xia, Fan ; Yang, Li ; Xiaoou, Su</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-c1af01cffc627c98c6bd0b29b3b2bf62ebf99bd660c752bec04e1cb650e5c4723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>2-Hydroxyphenethylamine - analogs & derivatives</topic><topic>2-Hydroxyphenethylamine - analysis</topic><topic>Adrenergic beta-Agonists - analysis</topic><topic>Animals</topic><topic>Chromatography, Liquid</topic><topic>Drug Residues - analysis</topic><topic>Female</topic><topic>Hair - chemistry</topic><topic>Male</topic><topic>Sheep</topic><topic>Substance Abuse Detection - instrumentation</topic><topic>Substance Abuse Detection - methods</topic><topic>Substance Abuse Detection - veterinary</topic><topic>Swine</topic><topic>Tandem Mass Spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Decheng, Suo</creatorcontrib><creatorcontrib>Ruiguo, Wang</creatorcontrib><creatorcontrib>Peilong, Wang</creatorcontrib><creatorcontrib>Genlong, Zhao</creatorcontrib><creatorcontrib>Yufei, Fan</creatorcontrib><creatorcontrib>Xia, Fan</creatorcontrib><creatorcontrib>Yang, Li</creatorcontrib><creatorcontrib>Xiaoou, Su</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Decheng, Suo</au><au>Ruiguo, Wang</au><au>Peilong, Wang</au><au>Genlong, Zhao</au><au>Yufei, Fan</au><au>Xia, Fan</au><au>Yang, Li</au><au>Xiaoou, Su</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accumulation and Determination of Phenylethanolamine A Residue in Hair of Swine and Sheep</atitle><jtitle>Journal of analytical toxicology</jtitle><addtitle>J Anal Toxicol</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>41</volume><issue>2</issue><spage>146</spage><epage>152</epage><pages>146-152</pages><issn>0146-4760</issn><eissn>1945-2403</eissn><abstract>The present study proposed the use of liquid chromatography-tandem mass spectrometry to detect the novel β-agonist phenylethanolamine A (PEA) in incurred hair samples of swine and sheep and to assess its accumulation for residue monitoring. The method showed good percent recoveries ranging from 93.2% to 102% and good coefficient of variation at <15%. The experiment was conducted in swine (24 treated and 4 controls) and sheep (3 treated and 1 control). PEA concentration was determined in hair during the treatment. High residue concentrations were present in hair as early as Day 24 (14.8 ± 3.6 and 25.8 ± 7.6 ng/g) and Day 21 (23.4 ± 6.6 ng/g) for swine and sheep; these residues persisted until withdrawal on Days 14 and 21. Results showed high PEA accumulation in hair, thereby indicating the use of hair as a matrix in the control of PEA abuse in farm animals.</abstract><cop>England</cop><pmid>27881619</pmid><doi>10.1093/jat/bkw121</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of analytical toxicology, 2017-03, Vol.41 (2), p.146-152 |
| issn | 0146-4760 1945-2403 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 2-Hydroxyphenethylamine - analogs & derivatives 2-Hydroxyphenethylamine - analysis Adrenergic beta-Agonists - analysis Animals Chromatography, Liquid Drug Residues - analysis Female Hair - chemistry Male Sheep Substance Abuse Detection - instrumentation Substance Abuse Detection - methods Substance Abuse Detection - veterinary Swine Tandem Mass Spectrometry |
| title | Accumulation and Determination of Phenylethanolamine A Residue in Hair of Swine and Sheep |
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