Improved Use of Workplace Exposure Data in the Regulatory Risk Assessment of Chemicals within Europe
The process of risk assessment for human health demands the availability of soundly based effects and exposure information. However, many of the available data, particularly those which seek to describe human exposures to chemicals, are of varying quality and scope. Changing public and regulatory ex...
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Veröffentlicht in: | The Annals of occupational hygiene 2002-04, Vol.46 (3), p.279-285 |
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creator | MONEY, C. D. MARGARY, S. A. |
description | The process of risk assessment for human health demands the availability of soundly based effects and exposure information. However, many of the available data, particularly those which seek to describe human exposures to chemicals, are of varying quality and scope. Changing public and regulatory expectations increasingly demand that the outcomes of risk assessments are seen to have duly accounted for these data, in order that their conclusions can be viewed as valid. The challenge for risk assessors, therefore, is how the different grades of data should be integrated within the overall process. A series of core values are identified that govern the relationships and the influence that different types of exposure data have within European Union (EU) regulatory risk assessment for chemicals. Building on these values, an approach is presented for evaluating workplace exposure information in the context of how such data might be used within the EU process for assessing the risks to human health of new and existing substances. The implications of adopting the approach for regulatory risk assessment within the EU and its consequent impact on current occupational hygiene practice are discussed. |
doi_str_mv | 10.1093/annhyg/mef044 |
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Building on these values, an approach is presented for evaluating workplace exposure information in the context of how such data might be used within the EU process for assessing the risks to human health of new and existing substances. The implications of adopting the approach for regulatory risk assessment within the EU and its consequent impact on current occupational hygiene practice are discussed.</description><identifier>ISSN: 0003-4878</identifier><identifier>ISSN: 1475-3162</identifier><identifier>EISSN: 1475-3162</identifier><identifier>DOI: 10.1093/annhyg/mef044</identifier><identifier>PMID: 12176715</identifier><identifier>CODEN: AOHYA3</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Biological and medical sciences ; Chemical and industrial products toxicology. 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D.</creatorcontrib><creatorcontrib>MARGARY, S. A.</creatorcontrib><title>Improved Use of Workplace Exposure Data in the Regulatory Risk Assessment of Chemicals within Europe</title><title>The Annals of occupational hygiene</title><addtitle>Ann Occup Hyg</addtitle><description>The process of risk assessment for human health demands the availability of soundly based effects and exposure information. However, many of the available data, particularly those which seek to describe human exposures to chemicals, are of varying quality and scope. Changing public and regulatory expectations increasingly demand that the outcomes of risk assessments are seen to have duly accounted for these data, in order that their conclusions can be viewed as valid. The challenge for risk assessors, therefore, is how the different grades of data should be integrated within the overall process. A series of core values are identified that govern the relationships and the influence that different types of exposure data have within European Union (EU) regulatory risk assessment for chemicals. Building on these values, an approach is presented for evaluating workplace exposure information in the context of how such data might be used within the EU process for assessing the risks to human health of new and existing substances. The implications of adopting the approach for regulatory risk assessment within the EU and its consequent impact on current occupational hygiene practice are discussed.</description><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chemical Industry</subject><subject>Data Collection</subject><subject>data evaluation</subject><subject>data quality</subject><subject>Europe</subject><subject>exposure data</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Occupational Exposure</subject><subject>Quality Control</subject><subject>Reference Values</subject><subject>Risk Assessment</subject><subject>Toxicology</subject><subject>Workplace</subject><issn>0003-4878</issn><issn>1475-3162</issn><issn>1475-3162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1P3DAQxa2Kqiy0x14rX-AWsOPYjo90WVgkpFaoqNVeLMeZsOnmC0_Ssv89RrtiT6OZ-b0ZvUfIV84uODPi0nXdevt02ULFsuwDmfFMy0RwlR6RGWNMJFmu82Nygvg3tpkw_BM55inXSnM5I-VdO4T-H5T0EYH2Ff3dh83QOA908TL0OAWg1250tO7ouAb6AE9T48Y-bOlDjRt6hQiILXTjm3i-hrb2rkH6vx7XUbKYQj_AZ_KxikP4sq-n5PFm8Wu-TO5_3N7Nr-4TL4wakwK0TI3W3nCXF4U0nBW8LAuuKtBOeyULrcH5vPI810aURURV5iAzrjKOiVNyvrsbLT1PgKNta_TQNK6DfkLL8-hfyTyCyQ70oUcMUNkh1K0LW8uZfYvV7mK1u1gj_21_eCpaKA_0PscInO0Bh9F_FVznazxwQqVSpunhcY0jvLzvXdhYpYWWdvlnZfP0-8-Vvl7alXgFXTmS9A</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>MONEY, C. 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Toxic occupational diseases</topic><topic>Chemical Industry</topic><topic>Data Collection</topic><topic>data evaluation</topic><topic>data quality</topic><topic>Europe</topic><topic>exposure data</topic><topic>General aspects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Occupational Exposure</topic><topic>Quality Control</topic><topic>Reference Values</topic><topic>Risk Assessment</topic><topic>Toxicology</topic><topic>Workplace</topic><toplevel>online_resources</toplevel><creatorcontrib>MONEY, C. D.</creatorcontrib><creatorcontrib>MARGARY, S. 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A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved Use of Workplace Exposure Data in the Regulatory Risk Assessment of Chemicals within Europe</atitle><jtitle>The Annals of occupational hygiene</jtitle><addtitle>Ann Occup Hyg</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>46</volume><issue>3</issue><spage>279</spage><epage>285</epage><pages>279-285</pages><issn>0003-4878</issn><issn>1475-3162</issn><eissn>1475-3162</eissn><coden>AOHYA3</coden><abstract>The process of risk assessment for human health demands the availability of soundly based effects and exposure information. However, many of the available data, particularly those which seek to describe human exposures to chemicals, are of varying quality and scope. Changing public and regulatory expectations increasingly demand that the outcomes of risk assessments are seen to have duly accounted for these data, in order that their conclusions can be viewed as valid. 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source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
subjects | Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chemical Industry Data Collection data evaluation data quality Europe exposure data General aspects Humans Medical sciences Occupational Exposure Quality Control Reference Values Risk Assessment Toxicology Workplace |
title | Improved Use of Workplace Exposure Data in the Regulatory Risk Assessment of Chemicals within Europe |
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