Neurographic course Of Wallerian degeneration after human peripheral nerve injury
ABSTRACT Introduction Neurographic data on Wallerian degeneration (WD) after motor nerve injury are available only from animal studies and human case reports of 9 patients altogether. A precise knowledge of neurographic features of WD would be highly relevant for diagnostic, prognostic, therapeutic,...
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| Veröffentlicht in: | Muscle & nerve 2017-08, Vol.56 (2), p.247-252 |
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| creator | Eder, Maria Schulte‐Mattler, Wilhelm Pöschl, Peter |
| description | ABSTRACT
Introduction
Neurographic data on Wallerian degeneration (WD) after motor nerve injury are available only from animal studies and human case reports of 9 patients altogether. A precise knowledge of neurographic features of WD would be highly relevant for diagnostic, prognostic, therapeutic, and forensic aspects of traumatic lesions.
Methods
We prospectively studied WD in patients with a peripheral nerve injury. They underwent sequential neurographic examinations beginning no later than 3 days after the injury until a plateau of the amplitude of compound muscle action potential was reached.
Results
We examined 20 injured nerves from 16 patients. Four days after injury, all nerves showed amplitude decay to some extent, whereas 85% had reached their plateau at day 8. A length dependency of WD could be demonstrated.
Conclusion
In humans, WD starts no later than day 4, shows length dependency, and is completed at day 8 in most nerves. Muscle Nerve 56: 247–252, 2017 |
| doi_str_mv | 10.1002/mus.25489 |
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Introduction
Neurographic data on Wallerian degeneration (WD) after motor nerve injury are available only from animal studies and human case reports of 9 patients altogether. A precise knowledge of neurographic features of WD would be highly relevant for diagnostic, prognostic, therapeutic, and forensic aspects of traumatic lesions.
Methods
We prospectively studied WD in patients with a peripheral nerve injury. They underwent sequential neurographic examinations beginning no later than 3 days after the injury until a plateau of the amplitude of compound muscle action potential was reached.
Results
We examined 20 injured nerves from 16 patients. Four days after injury, all nerves showed amplitude decay to some extent, whereas 85% had reached their plateau at day 8. A length dependency of WD could be demonstrated.
Conclusion
In humans, WD starts no later than day 4, shows length dependency, and is completed at day 8 in most nerves. Muscle Nerve 56: 247–252, 2017</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.25489</identifier><identifier>PMID: 27875622</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Action potential ; Action Potentials - physiology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; axonal lesion ; Case reports ; Degeneration ; Diagnostic systems ; Disease Progression ; Electromyography ; Female ; Forensic engineering ; Forensic science ; Humans ; Injuries ; Lesions ; Male ; Middle Aged ; Motor task performance ; Nerves ; Neural Conduction - physiology ; Neurodegeneration ; neurography ; Patients ; peripheral nerve ; Peripheral Nerve Injuries - complications ; Peripheral nerves ; Prospective Studies ; Time Factors ; trauma ; Ulnar Nerve - physiopathology ; Wallerian degeneration ; Wallerian Degeneration - diagnosis ; Wallerian Degeneration - etiology ; Young Adult</subject><ispartof>Muscle & nerve, 2017-08, Vol.56 (2), p.247-252</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3199-b2c10748e064559590b5b7e5cba2198f2e08965e08d4fe1ff3cccb20035d5ea73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.25489$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.25489$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27875622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eder, Maria</creatorcontrib><creatorcontrib>Schulte‐Mattler, Wilhelm</creatorcontrib><creatorcontrib>Pöschl, Peter</creatorcontrib><title>Neurographic course Of Wallerian degeneration after human peripheral nerve injury</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>ABSTRACT
Introduction
Neurographic data on Wallerian degeneration (WD) after motor nerve injury are available only from animal studies and human case reports of 9 patients altogether. A precise knowledge of neurographic features of WD would be highly relevant for diagnostic, prognostic, therapeutic, and forensic aspects of traumatic lesions.
Methods
We prospectively studied WD in patients with a peripheral nerve injury. They underwent sequential neurographic examinations beginning no later than 3 days after the injury until a plateau of the amplitude of compound muscle action potential was reached.
Results
We examined 20 injured nerves from 16 patients. Four days after injury, all nerves showed amplitude decay to some extent, whereas 85% had reached their plateau at day 8. A length dependency of WD could be demonstrated.
Conclusion
In humans, WD starts no later than day 4, shows length dependency, and is completed at day 8 in most nerves. Muscle Nerve 56: 247–252, 2017</description><subject>Action potential</subject><subject>Action Potentials - physiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>axonal lesion</subject><subject>Case reports</subject><subject>Degeneration</subject><subject>Diagnostic systems</subject><subject>Disease Progression</subject><subject>Electromyography</subject><subject>Female</subject><subject>Forensic engineering</subject><subject>Forensic science</subject><subject>Humans</subject><subject>Injuries</subject><subject>Lesions</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor task performance</subject><subject>Nerves</subject><subject>Neural Conduction - physiology</subject><subject>Neurodegeneration</subject><subject>neurography</subject><subject>Patients</subject><subject>peripheral nerve</subject><subject>Peripheral Nerve Injuries - complications</subject><subject>Peripheral nerves</subject><subject>Prospective Studies</subject><subject>Time Factors</subject><subject>trauma</subject><subject>Ulnar Nerve - physiopathology</subject><subject>Wallerian degeneration</subject><subject>Wallerian Degeneration - diagnosis</subject><subject>Wallerian Degeneration - etiology</subject><subject>Young Adult</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1LAzEQhoMotlYP_gEJePGybT53k6MUv6BaRIveQjadbbfsl9mu0n9vbKsHL5nA8zDMzIvQOSVDSggblV07ZFIofYD6lOgkElKrQ9QnVKgo5vq9h07adkUIoSpOjlGPJSqRMWN99PwEna8X3jbL3GFXd74FPM3wmy0K8Lmt8BwWUIG367yusM3W4PGyKwNoAm-WgRQ48E_AebXq_OYUHWW2aOFsXwdodnvzOr6PJtO7h_H1JHKcah2lzFGSCAUkFlJqqUkq0wSkSy2jWmUMiNKxDO9cZECzjDvnUkYIl3MJNuEDdLXr2_j6o4N2bcq8dVAUtoK6aw1VgmvGmZRBvfynrsKiVZjOUE2DxJWgwbrYW11awtw0Pi-t35jfYwVhtBO-8gI2f5wS85OCCSmYbQrmcfay_fBvOSB5gg</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Eder, Maria</creator><creator>Schulte‐Mattler, Wilhelm</creator><creator>Pöschl, Peter</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Neurographic course Of Wallerian degeneration after human peripheral nerve injury</title><author>Eder, Maria ; Schulte‐Mattler, Wilhelm ; Pöschl, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3199-b2c10748e064559590b5b7e5cba2198f2e08965e08d4fe1ff3cccb20035d5ea73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Action potential</topic><topic>Action Potentials - physiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>axonal lesion</topic><topic>Case reports</topic><topic>Degeneration</topic><topic>Diagnostic systems</topic><topic>Disease Progression</topic><topic>Electromyography</topic><topic>Female</topic><topic>Forensic engineering</topic><topic>Forensic science</topic><topic>Humans</topic><topic>Injuries</topic><topic>Lesions</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor task performance</topic><topic>Nerves</topic><topic>Neural Conduction - physiology</topic><topic>Neurodegeneration</topic><topic>neurography</topic><topic>Patients</topic><topic>peripheral nerve</topic><topic>Peripheral Nerve Injuries - complications</topic><topic>Peripheral nerves</topic><topic>Prospective Studies</topic><topic>Time Factors</topic><topic>trauma</topic><topic>Ulnar Nerve - physiopathology</topic><topic>Wallerian degeneration</topic><topic>Wallerian Degeneration - diagnosis</topic><topic>Wallerian Degeneration - etiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eder, Maria</creatorcontrib><creatorcontrib>Schulte‐Mattler, Wilhelm</creatorcontrib><creatorcontrib>Pöschl, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eder, Maria</au><au>Schulte‐Mattler, Wilhelm</au><au>Pöschl, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurographic course Of Wallerian degeneration after human peripheral nerve injury</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2017-08</date><risdate>2017</risdate><volume>56</volume><issue>2</issue><spage>247</spage><epage>252</epage><pages>247-252</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>ABSTRACT
Introduction
Neurographic data on Wallerian degeneration (WD) after motor nerve injury are available only from animal studies and human case reports of 9 patients altogether. A precise knowledge of neurographic features of WD would be highly relevant for diagnostic, prognostic, therapeutic, and forensic aspects of traumatic lesions.
Methods
We prospectively studied WD in patients with a peripheral nerve injury. They underwent sequential neurographic examinations beginning no later than 3 days after the injury until a plateau of the amplitude of compound muscle action potential was reached.
Results
We examined 20 injured nerves from 16 patients. Four days after injury, all nerves showed amplitude decay to some extent, whereas 85% had reached their plateau at day 8. A length dependency of WD could be demonstrated.
Conclusion
In humans, WD starts no later than day 4, shows length dependency, and is completed at day 8 in most nerves. Muscle Nerve 56: 247–252, 2017</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27875622</pmid><doi>10.1002/mus.25489</doi><tpages>6</tpages></addata></record> |
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| subjects | Action potential Action Potentials - physiology Adolescent Adult Aged Aged, 80 and over axonal lesion Case reports Degeneration Diagnostic systems Disease Progression Electromyography Female Forensic engineering Forensic science Humans Injuries Lesions Male Middle Aged Motor task performance Nerves Neural Conduction - physiology Neurodegeneration neurography Patients peripheral nerve Peripheral Nerve Injuries - complications Peripheral nerves Prospective Studies Time Factors trauma Ulnar Nerve - physiopathology Wallerian degeneration Wallerian Degeneration - diagnosis Wallerian Degeneration - etiology Young Adult |
| title | Neurographic course Of Wallerian degeneration after human peripheral nerve injury |
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