CB-Receptor Agonist HU-210 Mimics the Postconditioning Phenomenon of Isolated Heart
CB receptor agonist HU-210 exhibits an infarction-limiting effect during in vitro reperfusion of the heart after focal ischemia. This effect is paralleled by a decrease in left-ventricular developed pressure and double product. In addition, HU-210 reduces end-diastolic pressure during the reperfusio...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2016-11, Vol.162 (1), p.27-29 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Gorbunov, A. S. Maslov, L. N. Tsibulnikov, S. Yu Khaliulin, I. G. Tsepokina, A. V. Khutornaya, M. V. Kutikhin, A. G. |
| description | CB receptor agonist HU-210 exhibits an infarction-limiting effect during
in vitro
reperfusion of the heart after focal ischemia. This effect is paralleled by a decrease in left-ventricular developed pressure and double product. In addition, HU-210 reduces end-diastolic pressure during the reperfusion period, which indirectly attests to reduced Ca
2+
overload of cardiomyocytes. |
| doi_str_mv | 10.1007/s10517-016-3536-6 |
| format | Article |
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in vitro
reperfusion of the heart after focal ischemia. This effect is paralleled by a decrease in left-ventricular developed pressure and double product. In addition, HU-210 reduces end-diastolic pressure during the reperfusion period, which indirectly attests to reduced Ca
2+
overload of cardiomyocytes.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-016-3536-6</identifier><identifier>PMID: 27878734</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Arrhythmias, Cardiac - drug therapy ; Arrhythmias, Cardiac - metabolism ; Arrhythmias, Cardiac - physiopathology ; Biomedical and Life Sciences ; Biomedicine ; Blood pressure ; Blood Pressure - drug effects ; Calcium ; Calcium - metabolism ; Cardiac patients ; Cardiomyocytes ; Cell Biology ; Coronary Occlusion ; Coronary Vessels - surgery ; Dronabinol - analogs & derivatives ; Dronabinol - pharmacology ; Excitatory Amino Acid Antagonists - pharmacology ; Heart ; Heart attack ; Heart failure ; Heart Rate - drug effects ; Infarction ; Internal Medicine ; Ischemia ; Ischemic Postconditioning ; Laboratory Medicine ; Male ; Myocardial Reperfusion Injury - drug therapy ; Myocardial Reperfusion Injury - metabolism ; Myocardial Reperfusion Injury - physiopathology ; Myocardium - metabolism ; Myocardium - pathology ; Myocytes, Cardiac - drug effects ; Myocytes, Cardiac - metabolism ; Neuroprotective Agents - pharmacology ; Organ Culture Techniques ; Pathology ; Rats ; Rats, Wistar ; Receptors, Cannabinoid - metabolism ; Reperfusion ; Shock ; Ventricle ; Ventricular Pressure - drug effects</subject><ispartof>Bulletin of experimental biology and medicine, 2016-11, Vol.162 (1), p.27-29</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c676t-da2c50c36b87a03719c01100857dce46abce77872b8ccb20dc1fcb32ee44fe563</citedby><cites>FETCH-LOGICAL-c676t-da2c50c36b87a03719c01100857dce46abce77872b8ccb20dc1fcb32ee44fe563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-016-3536-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-016-3536-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27878734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gorbunov, A. S.</creatorcontrib><creatorcontrib>Maslov, L. N.</creatorcontrib><creatorcontrib>Tsibulnikov, S. Yu</creatorcontrib><creatorcontrib>Khaliulin, I. G.</creatorcontrib><creatorcontrib>Tsepokina, A. V.</creatorcontrib><creatorcontrib>Khutornaya, M. V.</creatorcontrib><creatorcontrib>Kutikhin, A. G.</creatorcontrib><title>CB-Receptor Agonist HU-210 Mimics the Postconditioning Phenomenon of Isolated Heart</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>CB receptor agonist HU-210 exhibits an infarction-limiting effect during
in vitro
reperfusion of the heart after focal ischemia. This effect is paralleled by a decrease in left-ventricular developed pressure and double product. In addition, HU-210 reduces end-diastolic pressure during the reperfusion period, which indirectly attests to reduced Ca
2+
overload of cardiomyocytes.</description><subject>Animals</subject><subject>Arrhythmias, Cardiac - drug therapy</subject><subject>Arrhythmias, Cardiac - metabolism</subject><subject>Arrhythmias, Cardiac - physiopathology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>Cardiac patients</subject><subject>Cardiomyocytes</subject><subject>Cell Biology</subject><subject>Coronary Occlusion</subject><subject>Coronary Vessels - surgery</subject><subject>Dronabinol - analogs & derivatives</subject><subject>Dronabinol - pharmacology</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Heart</subject><subject>Heart attack</subject><subject>Heart failure</subject><subject>Heart Rate - drug effects</subject><subject>Infarction</subject><subject>Internal Medicine</subject><subject>Ischemia</subject><subject>Ischemic Postconditioning</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Myocardial Reperfusion Injury - drug therapy</subject><subject>Myocardial Reperfusion Injury - metabolism</subject><subject>Myocardial Reperfusion Injury - physiopathology</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Myocytes, Cardiac - drug effects</subject><subject>Myocytes, Cardiac - metabolism</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Organ Culture Techniques</subject><subject>Pathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Cannabinoid - metabolism</subject><subject>Reperfusion</subject><subject>Shock</subject><subject>Ventricle</subject><subject>Ventricular Pressure - drug effects</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU2LFDEQhoMo7jj6A7xIQBAvWfPRSaePs4M6Cysu6p5DOl0900t3Mibpg__eNLPqrihFCJU8VVS9L0IvGT1nlNbvEqOS1YQyRYQUiqhHaMVkLYjmnD1GK1ogUmmtz9CzlG6XlCr2FJ3xWpcQ1Qp93V6QL-DgmEPEm33wQ8p4d0M4o_jTMA0u4XwAfB1SdsF3Qx4K4vf4-gA-TOV4HHp8mcJoM3R4Bzbm5-hJb8cEL-7uNbr58P7bdkeuPn-83G6uiFO1yqSz3EnqhGp1bamoWeMoK3tpWXcOKmVbB3UZk7fauZbTzrHetYIDVFUPUok1envqe4zh-wwpm2lIDsbReghzMkxXouFUNrqgr_9Cb8McfZmuUIrqpmKK_aH2dgQz-D7kaN3S1GyqRkstZFF3jc7_QZXooOgVPPRDeX9Q8OZewQHsmA9FsHnRMj0E2Ql0MaQUoTfHOEw2_jCMmsVxc3LcFMfN4rhZRHh1t9ncTtD9rvhlcQH4CUjly-8h3lv9v11_Ai1Cshs</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Gorbunov, A. 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in vitro
reperfusion of the heart after focal ischemia. This effect is paralleled by a decrease in left-ventricular developed pressure and double product. In addition, HU-210 reduces end-diastolic pressure during the reperfusion period, which indirectly attests to reduced Ca
2+
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| subjects | Animals Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - physiopathology Biomedical and Life Sciences Biomedicine Blood pressure Blood Pressure - drug effects Calcium Calcium - metabolism Cardiac patients Cardiomyocytes Cell Biology Coronary Occlusion Coronary Vessels - surgery Dronabinol - analogs & derivatives Dronabinol - pharmacology Excitatory Amino Acid Antagonists - pharmacology Heart Heart attack Heart failure Heart Rate - drug effects Infarction Internal Medicine Ischemia Ischemic Postconditioning Laboratory Medicine Male Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - physiopathology Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Neuroprotective Agents - pharmacology Organ Culture Techniques Pathology Rats Rats, Wistar Receptors, Cannabinoid - metabolism Reperfusion Shock Ventricle Ventricular Pressure - drug effects |
| title | CB-Receptor Agonist HU-210 Mimics the Postconditioning Phenomenon of Isolated Heart |
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