Transmural Differences in Mechanical Properties of Isolated Subendocardial and Subepicardial Cardiomyocytes
We studied the differences in twitch force of subendocardial and subepicardial cardiomyocytes isolated from mouse left ventricular wall at different preloads using an original single cell stretch method recently developed by us. Then, we used our mathematical models of subendocardial and subepicardi...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2016-11, Vol.162 (1), p.48-50 |
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| creator | Khokhlova, A. D. Iribe, G. |
| description | We studied the differences in twitch force of subendocardial and subepicardial cardiomyocytes isolated from mouse left ventricular wall at different preloads using an original single cell stretch method recently developed by us. Then, we used our mathematical models of subendocardial and subepicardial cells to predict underlying cellular mechanisms. Transmural differences in the amplitudes of active tension of subendocardial and subepicardial cardiomyocytes were revealed that could be related to the differences in cooperative end-to-end interaction between the neighboring regulatory units of the thin filament. |
| doi_str_mv | 10.1007/s10517-016-3542-8 |
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D.</creatorcontrib><creatorcontrib>Iribe, G.</creatorcontrib><title>Transmural Differences in Mechanical Properties of Isolated Subendocardial and Subepicardial Cardiomyocytes</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We studied the differences in twitch force of subendocardial and subepicardial cardiomyocytes isolated from mouse left ventricular wall at different preloads using an original single cell stretch method recently developed by us. Then, we used our mathematical models of subendocardial and subepicardial cells to predict underlying cellular mechanisms. Transmural differences in the amplitudes of active tension of subendocardial and subepicardial cardiomyocytes were revealed that could be related to the differences in cooperative end-to-end interaction between the neighboring regulatory units of the thin filament.</description><subject>Animal models</subject><subject>Animals</subject><subject>Biomechanical Phenomena</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiomyocytes</subject><subject>Cell Biology</subject><subject>Endocardium - cytology</subject><subject>Endocardium - physiology</subject><subject>Heart</subject><subject>Heart cells</subject><subject>Heart Ventricles - cytology</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Mathematical models</subject><subject>Mechanical properties</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Muscle Stretching Exercises</subject><subject>Muscle Tonus - physiology</subject><subject>Myocytes, Cardiac - physiology</subject><subject>Pathology</subject><subject>Pericardium - cytology</subject><subject>Pericardium - physiology</subject><subject>Primary Cell Culture</subject><subject>Single-Cell Analysis</subject><subject>Ventricle</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kk1v1DAQhi0EotvCD-CCIiGhXlL8kcTOsdryUakIJMrZmjjjrktiL3Zy2H-Po7TQIvAcLM8878hjv4S8YvSMUSrfJUZrJkvKmlLUFS_VE7JhtRSl4pw9JRuaobJSSh2R45RulyNt2HNyxKXKwdoN-XEdwadxjjAUF85ajOgNpsL54jOaHXhncuVrDHuMk8uFYIvLFAaYsC--zR36PhiIvcsU-DW1d_eZ7bKH8RDMYcL0gjyzMCR8ebefkO8f3l9vP5VXXz5ebs-vStPIZipVnRfvLAgUVLSgqrY3bW17MKptoOlaS2klWdcDbzrVW5Cd5QYscFu1EsUJOV377mP4OWOa9OiSwWEAj2FOmqlKtJxyyTL65i_0NszR59tlqqGqrYQUf6gbGFA7b8MUwSxN9XnVqlqJulmos39QOXocnQkercv5R4K3DwQ7hGHa5aedJxd8egyyFTQxpBTR6n10I8SDZlQvTtCrE3R2gl6coFXWvL6bbO5G7H8r7r8-A3wFUi75G4wPRv9v119byL2U</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Khokhlova, A. 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| subjects | Animal models Animals Biomechanical Phenomena Biomedical and Life Sciences Biomedicine Cardiomyocytes Cell Biology Endocardium - cytology Endocardium - physiology Heart Heart cells Heart Ventricles - cytology Internal Medicine Laboratory Medicine Mathematical models Mechanical properties Mice Mice, Inbred C57BL Muscle Stretching Exercises Muscle Tonus - physiology Myocytes, Cardiac - physiology Pathology Pericardium - cytology Pericardium - physiology Primary Cell Culture Single-Cell Analysis Ventricle |
| title | Transmural Differences in Mechanical Properties of Isolated Subendocardial and Subepicardial Cardiomyocytes |
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