Exercise Attenuates High-Fat Diet–induced Disease Progression in 3xTg-AD Mice
PURPOSELittle is known regarding the therapeutic role of exercise against the risk of a high-fat diet (HFD) for Alzheimerʼs disease (AD) and AD-like cognitive deficits. This study aimed to investigate the therapeutic effect of treadmill running against HFD-induced progression in AD neuropathology an...
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| Veröffentlicht in: | Medicine and science in sports and exercise 2017-04, Vol.49 (4), p.676-686 |
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| container_title | Medicine and science in sports and exercise |
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| creator | KIM, DONGHYUN CHO, JINKYUNG LEE, INHWAN JIN, YOUNGYUN KANG, HYUNSIK |
| description | PURPOSELittle is known regarding the therapeutic role of exercise against the risk of a high-fat diet (HFD) for Alzheimerʼs disease (AD) and AD-like cognitive deficits. This study aimed to investigate the therapeutic effect of treadmill running against HFD-induced progression in AD neuropathology and cognitive impairments in the triple-transgenic AD (3xTg-AD) mice.
METHODSThe 3xTg-AD mice were assigned to a chow diet (control, n = 10), an HFD (n = 10), or an HFD combined with exercise (HFD + EX, n = 10) group. Mice in the HFD were fed with a 60% fat diet for 20 wk. The HFD + EX mice were additionally subjected to treadmill running.
RESULTSCompared with the control mice, the HFD mice had impaired brain insulin signaling, exacerbated AD neuropathology, defects in synaptic stability/plasticity, and apoptotic neuronal cell death in conjunction with exacerbated cognitive deficits in the affected brain regions, which were all significantly alleviated in the HFD + EX mice.
CONCLUSIONThe current findings suggest that treadmill running protects against AD-like disease progression and cognitive deficits caused by an HFD in the 3xTg-AD mice. |
| doi_str_mv | 10.1249/MSS.0000000000001166 |
| format | Article |
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METHODSThe 3xTg-AD mice were assigned to a chow diet (control, n = 10), an HFD (n = 10), or an HFD combined with exercise (HFD + EX, n = 10) group. Mice in the HFD were fed with a 60% fat diet for 20 wk. The HFD + EX mice were additionally subjected to treadmill running.
RESULTSCompared with the control mice, the HFD mice had impaired brain insulin signaling, exacerbated AD neuropathology, defects in synaptic stability/plasticity, and apoptotic neuronal cell death in conjunction with exacerbated cognitive deficits in the affected brain regions, which were all significantly alleviated in the HFD + EX mice.
CONCLUSIONThe current findings suggest that treadmill running protects against AD-like disease progression and cognitive deficits caused by an HFD in the 3xTg-AD mice.</description><identifier>ISSN: 0195-9131</identifier><identifier>EISSN: 1530-0315</identifier><identifier>DOI: 10.1249/MSS.0000000000001166</identifier><identifier>PMID: 27875496</identifier><language>eng</language><publisher>United States: American College of Sports Medicine</publisher><subject>Alzheimer Disease - metabolism ; Alzheimer Disease - physiopathology ; Amyloid - metabolism ; Animals ; Apoptosis ; Blood Glucose - metabolism ; Brain - metabolism ; Brain-Derived Neurotrophic Factor ; Cholesterol - blood ; Diet, High-Fat ; Disease Models, Animal ; Disease Progression ; Down-Regulation ; Insulin - blood ; Insulin - metabolism ; Male ; Mice, Transgenic ; Neuronal Plasticity ; Physical Conditioning, Animal - physiology ; Running - physiology ; tau Proteins - metabolism ; Triglycerides - blood</subject><ispartof>Medicine and science in sports and exercise, 2017-04, Vol.49 (4), p.676-686</ispartof><rights>2017 American College of Sports Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3566-9a4ae1e1cc83d2404cc452d4e3a7c1b5099a6f8c289809c36749fb26b8ce21673</citedby><cites>FETCH-LOGICAL-c3566-9a4ae1e1cc83d2404cc452d4e3a7c1b5099a6f8c289809c36749fb26b8ce21673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27875496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIM, DONGHYUN</creatorcontrib><creatorcontrib>CHO, JINKYUNG</creatorcontrib><creatorcontrib>LEE, INHWAN</creatorcontrib><creatorcontrib>JIN, YOUNGYUN</creatorcontrib><creatorcontrib>KANG, HYUNSIK</creatorcontrib><title>Exercise Attenuates High-Fat Diet–induced Disease Progression in 3xTg-AD Mice</title><title>Medicine and science in sports and exercise</title><addtitle>Med Sci Sports Exerc</addtitle><description>PURPOSELittle is known regarding the therapeutic role of exercise against the risk of a high-fat diet (HFD) for Alzheimerʼs disease (AD) and AD-like cognitive deficits. This study aimed to investigate the therapeutic effect of treadmill running against HFD-induced progression in AD neuropathology and cognitive impairments in the triple-transgenic AD (3xTg-AD) mice.
METHODSThe 3xTg-AD mice were assigned to a chow diet (control, n = 10), an HFD (n = 10), or an HFD combined with exercise (HFD + EX, n = 10) group. Mice in the HFD were fed with a 60% fat diet for 20 wk. The HFD + EX mice were additionally subjected to treadmill running.
RESULTSCompared with the control mice, the HFD mice had impaired brain insulin signaling, exacerbated AD neuropathology, defects in synaptic stability/plasticity, and apoptotic neuronal cell death in conjunction with exacerbated cognitive deficits in the affected brain regions, which were all significantly alleviated in the HFD + EX mice.
CONCLUSIONThe current findings suggest that treadmill running protects against AD-like disease progression and cognitive deficits caused by an HFD in the 3xTg-AD mice.</description><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Amyloid - metabolism</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Blood Glucose - metabolism</subject><subject>Brain - metabolism</subject><subject>Brain-Derived Neurotrophic Factor</subject><subject>Cholesterol - blood</subject><subject>Diet, High-Fat</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Down-Regulation</subject><subject>Insulin - blood</subject><subject>Insulin - metabolism</subject><subject>Male</subject><subject>Mice, Transgenic</subject><subject>Neuronal Plasticity</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Running - physiology</subject><subject>tau Proteins - metabolism</subject><subject>Triglycerides - blood</subject><issn>0195-9131</issn><issn>1530-0315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EouXxBwhlySbgiR3HXla8pVZFallHjjNtDWlSbEfAjn_gD_kSgloQYsFsRiOde0c6hBwBPYWEq7PRZHJKfw2AEFukDymjMWWQbpM-BZXGChj0yJ73Dx2UMQa7pJdkMku5En0yvnxBZ6zHaBAC1q0O6KMbO1_EVzpEFxbDx9u7rcvWYNmdHnWH3rlm7tB729SRrSP2Mp3Hg4toZA0ekJ2ZrjwebvY-ub-6nJ7fxMPx9e35YBgblgoRK801AoIxkpUJp9wYniYlR6YzA0VKldJiJk0ilaTKMJFxNSsSUUiDCYiM7ZOTde_KNU8t-pAvrTdYVbrGpvU5SM4USJHKDuVr1LjGe4ezfOXsUrvXHGj-pTLvVOZ_VXax482Htlhi-RP6dtcBcg08N1VA5x-r9hldvkBdhcX_3Z_kqn8-</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>KIM, DONGHYUN</creator><creator>CHO, JINKYUNG</creator><creator>LEE, INHWAN</creator><creator>JIN, YOUNGYUN</creator><creator>KANG, HYUNSIK</creator><general>American College of Sports Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201704</creationdate><title>Exercise Attenuates High-Fat Diet–induced Disease Progression in 3xTg-AD Mice</title><author>KIM, DONGHYUN ; CHO, JINKYUNG ; LEE, INHWAN ; JIN, YOUNGYUN ; KANG, HYUNSIK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3566-9a4ae1e1cc83d2404cc452d4e3a7c1b5099a6f8c289809c36749fb26b8ce21673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Amyloid - metabolism</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Blood Glucose - metabolism</topic><topic>Brain - metabolism</topic><topic>Brain-Derived Neurotrophic Factor</topic><topic>Cholesterol - blood</topic><topic>Diet, High-Fat</topic><topic>Disease Models, Animal</topic><topic>Disease Progression</topic><topic>Down-Regulation</topic><topic>Insulin - blood</topic><topic>Insulin - metabolism</topic><topic>Male</topic><topic>Mice, Transgenic</topic><topic>Neuronal Plasticity</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Running - physiology</topic><topic>tau Proteins - metabolism</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIM, DONGHYUN</creatorcontrib><creatorcontrib>CHO, JINKYUNG</creatorcontrib><creatorcontrib>LEE, INHWAN</creatorcontrib><creatorcontrib>JIN, YOUNGYUN</creatorcontrib><creatorcontrib>KANG, HYUNSIK</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medicine and science in sports and exercise</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIM, DONGHYUN</au><au>CHO, JINKYUNG</au><au>LEE, INHWAN</au><au>JIN, YOUNGYUN</au><au>KANG, HYUNSIK</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise Attenuates High-Fat Diet–induced Disease Progression in 3xTg-AD Mice</atitle><jtitle>Medicine and science in sports and exercise</jtitle><addtitle>Med Sci Sports Exerc</addtitle><date>2017-04</date><risdate>2017</risdate><volume>49</volume><issue>4</issue><spage>676</spage><epage>686</epage><pages>676-686</pages><issn>0195-9131</issn><eissn>1530-0315</eissn><abstract>PURPOSELittle is known regarding the therapeutic role of exercise against the risk of a high-fat diet (HFD) for Alzheimerʼs disease (AD) and AD-like cognitive deficits. This study aimed to investigate the therapeutic effect of treadmill running against HFD-induced progression in AD neuropathology and cognitive impairments in the triple-transgenic AD (3xTg-AD) mice.
METHODSThe 3xTg-AD mice were assigned to a chow diet (control, n = 10), an HFD (n = 10), or an HFD combined with exercise (HFD + EX, n = 10) group. Mice in the HFD were fed with a 60% fat diet for 20 wk. The HFD + EX mice were additionally subjected to treadmill running.
RESULTSCompared with the control mice, the HFD mice had impaired brain insulin signaling, exacerbated AD neuropathology, defects in synaptic stability/plasticity, and apoptotic neuronal cell death in conjunction with exacerbated cognitive deficits in the affected brain regions, which were all significantly alleviated in the HFD + EX mice.
CONCLUSIONThe current findings suggest that treadmill running protects against AD-like disease progression and cognitive deficits caused by an HFD in the 3xTg-AD mice.</abstract><cop>United States</cop><pub>American College of Sports Medicine</pub><pmid>27875496</pmid><doi>10.1249/MSS.0000000000001166</doi><tpages>11</tpages></addata></record> |
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| ispartof | Medicine and science in sports and exercise, 2017-04, Vol.49 (4), p.676-686 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Ovid Autoload |
| subjects | Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Amyloid - metabolism Animals Apoptosis Blood Glucose - metabolism Brain - metabolism Brain-Derived Neurotrophic Factor Cholesterol - blood Diet, High-Fat Disease Models, Animal Disease Progression Down-Regulation Insulin - blood Insulin - metabolism Male Mice, Transgenic Neuronal Plasticity Physical Conditioning, Animal - physiology Running - physiology tau Proteins - metabolism Triglycerides - blood |
| title | Exercise Attenuates High-Fat Diet–induced Disease Progression in 3xTg-AD Mice |
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