Characterization of the anti-inflammation mechanism for the AO herbal extract
A broad range of cytokines are secreted during the inflammatory response by the immune system. Some cytokines promote inflammation, while others inhibit inflammation. Inflammatory cytokines work in harmony when they encounter external pathogens or internal dangers. Inflammation is resolved after the...
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| Veröffentlicht in: | Experimental and molecular pathology 2016-12, Vol.101 (3), p.341-345 |
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| creator | Ye, Hong Wang, Yali Yan, Jun Jenson, A. Bennett |
| description | A broad range of cytokines are secreted during the inflammatory response by the immune system. Some cytokines promote inflammation, while others inhibit inflammation. Inflammatory cytokines work in harmony when they encounter external pathogens or internal dangers. Inflammation is resolved after the cause is eliminated. However, if the cause persists, it can lead to significant diseases. The pro-inflammatory cytokine TNFα is a biomarker for the inflammatory response. The AO herbal mixture extracted from 10 medicinal herbs has been investigated for its ability to control the inflammatory process and to inhibit TNFα activity. To find the treatment for inflammation related diseases, we examined whether the AO herbal extract is able to affect the activities of other cytokines. Here we present that the AO herbal extract is able to inhibit pro-inflammatory factor activities including IL-1α. However, it does not affect the activities of IL-1β and IL-6. Interestingly, it promotes the activity of anti-inflammatory factors including IL-4 and IL-13. |
| doi_str_mv | 10.1016/j.yexmp.2016.11.005 |
| format | Article |
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Bennett</creator><creatorcontrib>Ye, Hong ; Wang, Yali ; Yan, Jun ; Jenson, A. Bennett</creatorcontrib><description>A broad range of cytokines are secreted during the inflammatory response by the immune system. Some cytokines promote inflammation, while others inhibit inflammation. Inflammatory cytokines work in harmony when they encounter external pathogens or internal dangers. Inflammation is resolved after the cause is eliminated. However, if the cause persists, it can lead to significant diseases. The pro-inflammatory cytokine TNFα is a biomarker for the inflammatory response. The AO herbal mixture extracted from 10 medicinal herbs has been investigated for its ability to control the inflammatory process and to inhibit TNFα activity. To find the treatment for inflammation related diseases, we examined whether the AO herbal extract is able to affect the activities of other cytokines. Here we present that the AO herbal extract is able to inhibit pro-inflammatory factor activities including IL-1α. However, it does not affect the activities of IL-1β and IL-6. Interestingly, it promotes the activity of anti-inflammatory factors including IL-4 and IL-13.</description><identifier>ISSN: 0014-4800</identifier><identifier>EISSN: 1096-0945</identifier><identifier>DOI: 10.1016/j.yexmp.2016.11.005</identifier><identifier>PMID: 27876570</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Anti-Inflammatory Agents - pharmacology ; Cells, Cultured ; Cytokines - genetics ; Cytokines - metabolism ; IL-13 ; IL-1α ; IL-1β ; IL-4 ; IL-6 ; Macrophages, Peritoneal - drug effects ; Macrophages, Peritoneal - metabolism ; Medicinal herb ; Mice ; Plant Extracts - pharmacology ; TNFα</subject><ispartof>Experimental and molecular pathology, 2016-12, Vol.101 (3), p.341-345</ispartof><rights>2016 The Authors</rights><rights>Copyright © 2016 The Authors. Published by Elsevier Inc. 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Bennett</creatorcontrib><title>Characterization of the anti-inflammation mechanism for the AO herbal extract</title><title>Experimental and molecular pathology</title><addtitle>Exp Mol Pathol</addtitle><description>A broad range of cytokines are secreted during the inflammatory response by the immune system. Some cytokines promote inflammation, while others inhibit inflammation. Inflammatory cytokines work in harmony when they encounter external pathogens or internal dangers. Inflammation is resolved after the cause is eliminated. However, if the cause persists, it can lead to significant diseases. The pro-inflammatory cytokine TNFα is a biomarker for the inflammatory response. The AO herbal mixture extracted from 10 medicinal herbs has been investigated for its ability to control the inflammatory process and to inhibit TNFα activity. To find the treatment for inflammation related diseases, we examined whether the AO herbal extract is able to affect the activities of other cytokines. Here we present that the AO herbal extract is able to inhibit pro-inflammatory factor activities including IL-1α. However, it does not affect the activities of IL-1β and IL-6. 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| ispartof | Experimental and molecular pathology, 2016-12, Vol.101 (3), p.341-345 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anti-Inflammatory Agents - pharmacology Cells, Cultured Cytokines - genetics Cytokines - metabolism IL-13 IL-1α IL-1β IL-4 IL-6 Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Medicinal herb Mice Plant Extracts - pharmacology TNFα |
| title | Characterization of the anti-inflammation mechanism for the AO herbal extract |
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