Induction of CYP1A1 and CYP1A2 expressions by prototypic and atypical inducers in the human lung

The inducibility of cytochrome P4501A1 gene ( CYP1A1) expression was examined in human lung samples from 27 subjects, using an explant culture system and semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. CYP1A1 transcripts were present in all of the lung specimens...

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Veröffentlicht in:	Cancer letters 2002-04, Vol.178 (1), p.25-36
Hauptverfasser:	Wei, Cindy, Caccavale, Robert J, Weyand, Eric H, Chen, Suzie, Iba, Michael M
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,7,8-tetrachlorodibenzo- p-dioxin 2-Hydroxypyridine Benzo(a)pyrene - pharmacology Benzo[a]pyrene Biological and medical sciences Blotting, Western Carcinogenesis, carcinogens and anticarcinogens Cells, Cultured Chemical agents Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP1A2 - genetics Cytochrome P-450 CYP1A2 - metabolism Cytochrome P4501A1 Cytochrome P4501A2 DNA - metabolism Dose-Response Relationship, Drug Environmental Pollutants - pharmacology Enzyme Induction Enzymes Explant Ganglionic Stimulants - pharmacology Gene Expression Regulation, Enzymologic - drug effects Human lung Humans Induction Lung - cytology Lung - enzymology Lung - metabolism Medical sciences Nicotine Nicotine - pharmacology Omeprazole Polychlorinated Dibenzodioxins - pharmacology Proteins Pyridine Pyridines - pharmacology Reverse Transcriptase Polymerase Chain Reaction Review boards RNA, Messenger - metabolism Studies Tissue Extracts Tobacco smoke Tumors
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