Interaction of HIV-1 Integrase with DNA Repair Protein hRad18

We have previously shown that human immunodeficiency virus-1 (HIV-1) integrase is an unstable protein and a substrate for the N-end rule degradation pathway. This degradation pathway shares its ubiquitin-conjugating enzyme, Rad6, with the post-replication/translesion DNA repair pathway. Because DNA...

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Veröffentlicht in:	The Journal of biological chemistry 2002-07, Vol.277 (30), p.27489-27493
Hauptverfasser:	Mulder, Lubbertus C.F., Chakrabarti, Lisa A., Muesing, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cell Line DNA Repair DNA-Binding Proteins - metabolism Gene Deletion HIV Integrase - metabolism Humans Microscopy, Fluorescence Mutation Plasmids - metabolism Precipitin Tests Protein Binding Protein Structure, Tertiary Retroviridae - genetics Transfection Ubiquitin-Protein Ligases
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