Evidence for Phosphate Adducts in DNA from Mice Treated with 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

The weakly alkylating capacity of phosphotriesters (PTE) has been used for the determination of adducts to phosphate groups in DNA by specific transfer to the strongly nucleophilic compound cob(I)alamin [Cbl(I)]. When enzymatically degraded liver DNA from mice treated with 1-(N-methyl-N-nitrosamino)...

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Veröffentlicht in:	Chemical research in toxicology 2002-06, Vol.15 (6), p.773-779
Hauptverfasser:	Haglund, Johanna, Henderson, Alistair P, Golding, Bernard T, Törnqvist, Margareta
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Animals Biotransformation Carcinogens - metabolism Carcinogens - toxicity Chromatography, High Pressure Liquid DNA - drug effects DNA - metabolism DNA Adducts - analysis DNA Adducts - biosynthesis Hydroxylation Liver - chemistry Liver - metabolism Mice Nitrosamines - metabolism Nitrosamines - toxicity Phosphates - metabolism Phosphoric Diester Hydrolases - chemistry Piperidines - chemistry Spectrophotometry, Ultraviolet Vitamin B 12 - analogs & derivatives Vitamin B 12 - chemistry
Online-Zugang:	Volltext
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