Sex-dependent toxicity of a novel acyl-coA:cholesterol acyltransferase inhibitor, YIC-C8-434, in relation to sex-specific forms of cytochrome P450 in rats

YIC-C8-434 is a novel inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT). To clarify the toxicity of YIC-C8-434, the compound was given orally to Sprague-Dawley rats for 28 days at 0, 4, 20, 100, or 500 mg/kg/day. The toxicity of the drug differed significantly between male and female r...

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Veröffentlicht in:	Toxicological sciences 2001-12, Vol.64 (2), p.259-268
Hauptverfasser:	KANEKO, Kimiyuki, UCHIDA, Kazum, KOBAYASHI, Toshihide, MIURA, Kouzou, TANOKURA, Keiko, HOSHINO, Kayoko, KATO, Ikuo, ONOUE, Masaharu, YOKOKURA, Teruo
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Body Weight - drug effects Cinnamates - adverse effects Cinnamates - pharmacokinetics Cytochrome P-450 Enzyme System - drug effects Cytochrome P-450 Enzyme System - metabolism Drug toxicity and drugs side effects treatment Eating - drug effects Enzyme Inhibitors - pharmacology Female Male Medical sciences Microsomes, Liver - metabolism Miscellaneous (drug allergy, mutagens, teratogens...) Organ Size - drug effects Pharmacology. Drug treatments Piperazines - adverse effects Piperazines - pharmacokinetics Proadifen - pharmacology Rats Rats, Sprague-Dawley Sex Factors Sterol O-Acyltransferase - antagonists & inhibitors
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