A short course of high‐dose cyclophosphamide induces long‐term survival of intestinal allografts in mice
Several transplant programs have recently added cyclophosphamide (CyP) to their immune suppression protocols in an attempt to reduce intestinal graft rejection rates. The present study was undertaken to confirm the benefits of this drug in a murine small bowel transplant model. A short course of mon...
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| Veröffentlicht in: | Transplant international 2001-08, Vol.14 (4), p.261-265 |
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| creator | Kellersmann, R. Zhong, R. Kellersmann, A. Kiyochi, H. Garcia, B. Grant, D. R. Gao, Z. H. |
| description | Several transplant programs have recently added cyclophosphamide (CyP) to their immune suppression protocols in an attempt to reduce intestinal graft rejection rates. The present study was undertaken to confirm the benefits of this drug in a murine small bowel transplant model. A short course of monotherapy with CyP 20 mg/kg per dose resulted in a mean survival time (MST) of 17.5 ± 3.6 days, compared with a MST of 7.5 ± 0.7 days in the untreated controls (p < 0.01). Cyclosporin A (CsA) 30 mg/kg per day produced comparable survival rates when used as monotherapy (MST: 14.2 ± 1.3 days) or in combination with CyP 20 mg/kg per dose (MST: 21.3 ± 5.1 days). Treatment with high dose CyP (40 mg/kg per dose) completely prevented graft loss in 8 of 10 animals (MST: 72.5 ± 5.3 days, p < 0.01). However, adding CsA abrogated the induction of long‐term survival achieved by CyP alone (MST: 23 ± 0.4 days). These data have important implications for the use of CyP in clinical transplantation. |
| doi_str_mv | 10.1111/j.1432-2277.2001.tb00055.x |
| format | Article |
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R. ; Gao, Z. H.</creator><creatorcontrib>Kellersmann, R. ; Zhong, R. ; Kellersmann, A. ; Kiyochi, H. ; Garcia, B. ; Grant, D. R. ; Gao, Z. H.</creatorcontrib><description>Several transplant programs have recently added cyclophosphamide (CyP) to their immune suppression protocols in an attempt to reduce intestinal graft rejection rates. The present study was undertaken to confirm the benefits of this drug in a murine small bowel transplant model. A short course of monotherapy with CyP 20 mg/kg per dose resulted in a mean survival time (MST) of 17.5 ± 3.6 days, compared with a MST of 7.5 ± 0.7 days in the untreated controls (p < 0.01). Cyclosporin A (CsA) 30 mg/kg per day produced comparable survival rates when used as monotherapy (MST: 14.2 ± 1.3 days) or in combination with CyP 20 mg/kg per dose (MST: 21.3 ± 5.1 days). Treatment with high dose CyP (40 mg/kg per dose) completely prevented graft loss in 8 of 10 animals (MST: 72.5 ± 5.3 days, p < 0.01). However, adding CsA abrogated the induction of long‐term survival achieved by CyP alone (MST: 23 ± 0.4 days). These data have important implications for the use of CyP in clinical transplantation.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/j.1432-2277.2001.tb00055.x</identifier><identifier>PMID: 11512060</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cyclophosphamide ; Cyclophosphamide - therapeutic use ; Cyclosporine - therapeutic use ; Graft Rejection ; Graft Survival - drug effects ; Graft vs Host Disease - prevention & control ; Immunomodulators ; Immunosuppression ; Immunosuppressive Agents - therapeutic use ; Intestine, Small - transplantation ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Pharmacology. Drug treatments ; Rejection ; Small bowel transplantation ; Transplantation, Homologous</subject><ispartof>Transplant international, 2001-08, Vol.14 (4), p.261-265</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4301-eae317981a786693f35d19816982f9ed1a3d958ea83dc72f87d23a639564f7f33</citedby><cites>FETCH-LOGICAL-c4301-eae317981a786693f35d19816982f9ed1a3d958ea83dc72f87d23a639564f7f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1432-2277.2001.tb00055.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1432-2277.2001.tb00055.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1122759$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11512060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kellersmann, R.</creatorcontrib><creatorcontrib>Zhong, R.</creatorcontrib><creatorcontrib>Kellersmann, A.</creatorcontrib><creatorcontrib>Kiyochi, H.</creatorcontrib><creatorcontrib>Garcia, B.</creatorcontrib><creatorcontrib>Grant, D. R.</creatorcontrib><creatorcontrib>Gao, Z. H.</creatorcontrib><title>A short course of high‐dose cyclophosphamide induces long‐term survival of intestinal allografts in mice</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>Several transplant programs have recently added cyclophosphamide (CyP) to their immune suppression protocols in an attempt to reduce intestinal graft rejection rates. The present study was undertaken to confirm the benefits of this drug in a murine small bowel transplant model. A short course of monotherapy with CyP 20 mg/kg per dose resulted in a mean survival time (MST) of 17.5 ± 3.6 days, compared with a MST of 7.5 ± 0.7 days in the untreated controls (p < 0.01). Cyclosporin A (CsA) 30 mg/kg per day produced comparable survival rates when used as monotherapy (MST: 14.2 ± 1.3 days) or in combination with CyP 20 mg/kg per dose (MST: 21.3 ± 5.1 days). Treatment with high dose CyP (40 mg/kg per dose) completely prevented graft loss in 8 of 10 animals (MST: 72.5 ± 5.3 days, p < 0.01). However, adding CsA abrogated the induction of long‐term survival achieved by CyP alone (MST: 23 ± 0.4 days). These data have important implications for the use of CyP in clinical transplantation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - therapeutic use</subject><subject>Cyclosporine - therapeutic use</subject><subject>Graft Rejection</subject><subject>Graft Survival - drug effects</subject><subject>Graft vs Host Disease - prevention & control</subject><subject>Immunomodulators</subject><subject>Immunosuppression</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Intestine, Small - transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred CBA</subject><subject>Pharmacology. Drug treatments</subject><subject>Rejection</subject><subject>Small bowel transplantation</subject><subject>Transplantation, Homologous</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMtq3DAYhUVpaKZpXyGYULqzo4ttSVkUQuglEAiEZC0UXcYaZGsi2Ulm10fIM_ZJIjMm7bbaiCN95_8PB4ATBCuUz-mmQjXBJcaUVhhCVI33EMKmqZ7fgdXb13uwgpzUJWS0PgQfU9pkCLMGfgCHCDUIwxaugD8vUhfiWKgwxWSKYIvOrbs_v190yFLtlA_bLqRtJ3unTeEGPSmTCh-GdYZGE_siTfHRPUo_m90wmjS6ISvpfVhHaceUX4veKfMJHFjpk_m83Efg7sf324tf5dX1z8uL86tS1QSi0khDEOUMScralhNLGo2ybDnDlhuNJNG8YUYyohXFllGNiWwJb9raUkvIEfi6n7uN4WHKeUTvkjLey8GEKQnEakw54Rk824MqhpSisWIbXS_jTiAo5q7FRsyFirlQMXctlq7FczYfL1um-97ov9al3Ax8WQCZlPQ2ykG59A-XpzZziG977Ml5s_uPBOL25hK3iLwC3_eeLg</recordid><startdate>200108</startdate><enddate>200108</enddate><creator>Kellersmann, R.</creator><creator>Zhong, R.</creator><creator>Kellersmann, A.</creator><creator>Kiyochi, H.</creator><creator>Garcia, B.</creator><creator>Grant, D. R.</creator><creator>Gao, Z. H.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>200108</creationdate><title>A short course of high‐dose cyclophosphamide induces long‐term survival of intestinal allografts in mice</title><author>Kellersmann, R. ; Zhong, R. ; Kellersmann, A. ; Kiyochi, H. ; Garcia, B. ; Grant, D. R. ; Gao, Z. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4301-eae317981a786693f35d19816982f9ed1a3d958ea83dc72f87d23a639564f7f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cyclophosphamide</topic><topic>Cyclophosphamide - therapeutic use</topic><topic>Cyclosporine - therapeutic use</topic><topic>Graft Rejection</topic><topic>Graft Survival - drug effects</topic><topic>Graft vs Host Disease - prevention & control</topic><topic>Immunomodulators</topic><topic>Immunosuppression</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Intestine, Small - transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred CBA</topic><topic>Pharmacology. Drug treatments</topic><topic>Rejection</topic><topic>Small bowel transplantation</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kellersmann, R.</creatorcontrib><creatorcontrib>Zhong, R.</creatorcontrib><creatorcontrib>Kellersmann, A.</creatorcontrib><creatorcontrib>Kiyochi, H.</creatorcontrib><creatorcontrib>Garcia, B.</creatorcontrib><creatorcontrib>Grant, D. R.</creatorcontrib><creatorcontrib>Gao, Z. 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H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A short course of high‐dose cyclophosphamide induces long‐term survival of intestinal allografts in mice</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2001-08</date><risdate>2001</risdate><volume>14</volume><issue>4</issue><spage>261</spage><epage>265</epage><pages>261-265</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>Several transplant programs have recently added cyclophosphamide (CyP) to their immune suppression protocols in an attempt to reduce intestinal graft rejection rates. The present study was undertaken to confirm the benefits of this drug in a murine small bowel transplant model. A short course of monotherapy with CyP 20 mg/kg per dose resulted in a mean survival time (MST) of 17.5 ± 3.6 days, compared with a MST of 7.5 ± 0.7 days in the untreated controls (p < 0.01). 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals |
| subjects | Animals Biological and medical sciences Cyclophosphamide Cyclophosphamide - therapeutic use Cyclosporine - therapeutic use Graft Rejection Graft Survival - drug effects Graft vs Host Disease - prevention & control Immunomodulators Immunosuppression Immunosuppressive Agents - therapeutic use Intestine, Small - transplantation Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Pharmacology. Drug treatments Rejection Small bowel transplantation Transplantation, Homologous |
| title | A short course of high‐dose cyclophosphamide induces long‐term survival of intestinal allografts in mice |
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