Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein

α-Synucleinopathies are neurodegenerative disorders that range pathologically from the demise of select groups of nuclei to pervasive degeneration throughout the neuraxis. Although mounting evidence suggests that α-synuclein lesions lead to neurodegeneration, this remains controversial. To explore t...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2002-05, Vol.34 (4), p.521-533
Hauptverfasser:	Giasson, Benoit I., Duda, John E., Quinn, Shawn M., Zhang, Bin, Trojanowski, John Q., Lee, Virginia M.-Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein Animals Axons - metabolism Axons - pathology Axons - ultrastructure Behavior, Animal - physiology Brain - metabolism Brain - pathology Brain - ultrastructure Disease Models, Animal Female Gene Expression Regulation - physiology Humans Inclusion Bodies - metabolism Inclusion Bodies - pathology Inclusion Bodies - ultrastructure Male Mice Mice, Transgenic Microscopy, Electron Movement Disorders - genetics Movement Disorders - metabolism Movement Disorders - pathology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - ultrastructure Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurons - metabolism Neurons - pathology Neurons - ultrastructure Phenotype Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - ultrastructure Solubility Spinal Cord - metabolism Spinal Cord - pathology Spinal Cord - ultrastructure Synucleins Wallerian Degeneration - genetics Wallerian Degeneration - metabolism Wallerian Degeneration - pathology
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