Statistically designed experiments in a tiered approach to screen mixtures of Fusarium mycotoxins for possible interactions

This paper presents a test strategy to detect interactive effects between several mycotoxins using a DNA synthesis inhibition assay in L929 cells. The joint action of the Fusarium mycotoxins T-2 toxin (T2), deoxynivalenol (DON), nivalenol (NIV), zearalenone (ZEA) and fumonisin (FB1) was studied in a...

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Veröffentlicht in:	Food and chemical toxicology 2002-05, Vol.40 (5), p.685-695
Hauptverfasser:	Tajima, O., Schoen, E.D., Feron, V.J., Groten, J.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Biological and medical sciences Cell Line Central composite design DNA - biosynthesis Dose-Response Relationship, Drug Drug Synergism Full factorial design Fusarium - chemistry Fusarium mycotoxins Interaction Joint action Linear Models Medical sciences Mice Mycotoxins - toxicity Nucleic Acid Synthesis Inhibitors - toxicity Plant poisons toxicology Tiered approach Toxicology
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