Synthesis and antitumor activity of novel substituted uracil-1′(N)-acetic acid ester derivatives of 20(S)-camptothecins

A series of novel substituted uracil-1′(N)-acetic acid esters (6–20) of camptothecins (CPTs) were synthesized by the acylation method. These new compounds were evaluated for in vitro antitumor activity against tumor cell lines, A549, Bel7402, BGC-823, HCT-8 and A2780. In vitro results showed that mo...

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Veröffentlicht in:	European journal of medicinal chemistry 2017-01, Vol.125, p.1235-1246
Hauptverfasser:	Li, Di-Zao, Zhang, Qiang-Zhe, Wang, Cun-Ying, Zhang, Yan-Ling, Li, Xing-Yu, Huang, Ji-Tao, Liu, Hong-Yan, Fu, Zhao-Di, Song, Hua-Xian, Lin, Jin-Ping, Ji, Teng-Fei, Pan, Xian-Dao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemical synthesis Acetates - chemistry Acetates - pharmacology Acetates - therapeutic use Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antitumor activity Camptothecin Camptothecin - analogs & derivatives Camptothecin - chemical synthesis Camptothecin - pharmacology Camptothecin - therapeutic use Cell Line, Tumor Cell Survival - drug effects DNA Topoisomerases, Type I - metabolism Humans Mice, Nude Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Substituted uracil-1′(N)-acetic acid Synthesis The mechanism of antitumor activity Topoisomerase I Inhibitors - chemical synthesis Topoisomerase I Inhibitors - chemistry Topoisomerase I Inhibitors - pharmacology Topoisomerase I Inhibitors - therapeutic use Uracil - analogs & derivatives Uracil - chemical synthesis Uracil - pharmacology Uracil - therapeutic use
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