Niclosamide ethanolamine inhibits artery constriction

[Display omitted] We previously demonstrated that the typical mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP) inhibited artery constriction, but CCCP was used only as a pharmacological tool. Niclosamide is an anthelmintic drug approved by FDA. Niclosamide ethanolamine (NEN) i...

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Veröffentlicht in:	Pharmacological research 2017-01, Vol.115, p.78-86
Hauptverfasser:	Li, Shan-Liang, Yan, Jie, Zhang, Yan-Qiu, Zhen, Chang-Lin, Liu, Ming-Yu, Jin, Jing, Gao, Jin-Lai, Xiao, Xiao-Lin, Shen, Xin, Tai, Yu, Hu, Nan, Zhang, Xin-Zi, Sun, Zhi-Jie, Dong, De-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Animals Antihypertensive Agents - pharmacology Aorta - drug effects Aorta - metabolism Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Artery Ethanolamine - pharmacology KATP Channels - antagonists & inhibitors Male Mesenteric Arteries - drug effects Mesenteric Arteries - metabolism Mice Mice, Inbred C57BL mitochondrial uncoupler Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism niclosamide Niclosamide - pharmacology Phenylephrine - pharmacology Rats Rats, Sprague-Dawley Vascular Diseases - drug therapy Vascular Diseases - metabolism Vasoconstriction - drug effects Vasodilation - drug effects Vasodilator Agents - pharmacology vasorelaxation
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