Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis
•Two modified polysaccharides (AcMZPS and AlMZPS) were isolated and purified.•Hyperlipidemic mice were established by high-fat-high-cholesterol emulsion.•The antioxidant and anti-hyperlipidemic effects were investigated.•Glucose was determined to the major monosaccharide component of polysaccharides...
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Veröffentlicht in: | International journal of biological macromolecules 2017-02, Vol.95, p.204-214 |
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creator | Xu, Nuo Ren, Zhenzhen Zhang, Jianjun Song, Xinling Gao, Zheng Jing, Huijuan Li, Shangshang Wang, Shouxian Jia, Le |
description | •Two modified polysaccharides (AcMZPS and AlMZPS) were isolated and purified.•Hyperlipidemic mice were established by high-fat-high-cholesterol emulsion.•The antioxidant and anti-hyperlipidemic effects were investigated.•Glucose was determined to the major monosaccharide component of polysaccharides.•Findings proved that AcMZPS and AlMZPS had prevention effects of hyperlipidemia.
The aims of this work were designed to investigate the hepatoprotective and antioxidant effects of acidic- and alkali-extractable mycelia zinc polysaccharides (AcMZPS, AlMZPS) from Pleurotus eryngii var. tuoliensis on high-fat-high-cholesterol emulsion-induced hyperlipidemic mice. The in vivo experiments demonstrated that both AcMZPS and AlMZPS had potential hepatoprotective effects by significantly decreasing the levels of LDL-C, VLDL-C, TC, TG, ALT, AST, ALP, MDA and LPO, and remarkably increasing the HDL-C, SOD, GSH-Px, and CAT in serum lipid/liver homogenate, respectively. In addition, four polysaccharide fractions of AcMZPS-1, AcMZPS-2, AlMZPS-1, and AlMZPS-2, purified from AcMZPS and AlMZPS using DEAE chromatography, respectively, were subjected to monosaccharide composition analysis and valuated for the in vitro antioxidant activity. The results obtained in present study suggested that AcMZPS, AlMZPS and their purified fractions could be used as functional foods and natural drugs in preventing the hyperlipidemia and non-alcoholic fatty liver. |
doi_str_mv | 10.1016/j.ijbiomac.2016.11.060 |
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The aims of this work were designed to investigate the hepatoprotective and antioxidant effects of acidic- and alkali-extractable mycelia zinc polysaccharides (AcMZPS, AlMZPS) from Pleurotus eryngii var. tuoliensis on high-fat-high-cholesterol emulsion-induced hyperlipidemic mice. The in vivo experiments demonstrated that both AcMZPS and AlMZPS had potential hepatoprotective effects by significantly decreasing the levels of LDL-C, VLDL-C, TC, TG, ALT, AST, ALP, MDA and LPO, and remarkably increasing the HDL-C, SOD, GSH-Px, and CAT in serum lipid/liver homogenate, respectively. In addition, four polysaccharide fractions of AcMZPS-1, AcMZPS-2, AlMZPS-1, and AlMZPS-2, purified from AcMZPS and AlMZPS using DEAE chromatography, respectively, were subjected to monosaccharide composition analysis and valuated for the in vitro antioxidant activity. The results obtained in present study suggested that AcMZPS, AlMZPS and their purified fractions could be used as functional foods and natural drugs in preventing the hyperlipidemia and non-alcoholic fatty liver.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2016.11.060</identifier><identifier>PMID: 27871790</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antihyperlipidemic effects ; Antioxidant effects ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Body Weight - drug effects ; Cytoprotection - drug effects ; Fungal Polysaccharides - chemistry ; Fungal Polysaccharides - pharmacology ; Fungal Polysaccharides - therapeutic use ; Hydrogen-Ion Concentration ; Hypolipidemic Agents - chemistry ; Hypolipidemic Agents - pharmacology ; Hypolipidemic Agents - therapeutic use ; Liver - drug effects ; Liver - pathology ; Mice ; Monosaccharides - analysis ; Mycelium - chemistry ; Pleurotus - chemistry ; Pleurotus eryngii var. tuoliensis ; Zinc - chemistry ; Zinc polysaccharides</subject><ispartof>International journal of biological macromolecules, 2017-02, Vol.95, p.204-214</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-36ad6246ebde04d6bdd7db2941bcc58f405eef7209004c86a49958883018d3283</citedby><cites>FETCH-LOGICAL-c368t-36ad6246ebde04d6bdd7db2941bcc58f405eef7209004c86a49958883018d3283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijbiomac.2016.11.060$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27871790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Nuo</creatorcontrib><creatorcontrib>Ren, Zhenzhen</creatorcontrib><creatorcontrib>Zhang, Jianjun</creatorcontrib><creatorcontrib>Song, Xinling</creatorcontrib><creatorcontrib>Gao, Zheng</creatorcontrib><creatorcontrib>Jing, Huijuan</creatorcontrib><creatorcontrib>Li, Shangshang</creatorcontrib><creatorcontrib>Wang, Shouxian</creatorcontrib><creatorcontrib>Jia, Le</creatorcontrib><title>Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>•Two modified polysaccharides (AcMZPS and AlMZPS) were isolated and purified.•Hyperlipidemic mice were established by high-fat-high-cholesterol emulsion.•The antioxidant and anti-hyperlipidemic effects were investigated.•Glucose was determined to the major monosaccharide component of polysaccharides.•Findings proved that AcMZPS and AlMZPS had prevention effects of hyperlipidemia.
The aims of this work were designed to investigate the hepatoprotective and antioxidant effects of acidic- and alkali-extractable mycelia zinc polysaccharides (AcMZPS, AlMZPS) from Pleurotus eryngii var. tuoliensis on high-fat-high-cholesterol emulsion-induced hyperlipidemic mice. The in vivo experiments demonstrated that both AcMZPS and AlMZPS had potential hepatoprotective effects by significantly decreasing the levels of LDL-C, VLDL-C, TC, TG, ALT, AST, ALP, MDA and LPO, and remarkably increasing the HDL-C, SOD, GSH-Px, and CAT in serum lipid/liver homogenate, respectively. In addition, four polysaccharide fractions of AcMZPS-1, AcMZPS-2, AlMZPS-1, and AlMZPS-2, purified from AcMZPS and AlMZPS using DEAE chromatography, respectively, were subjected to monosaccharide composition analysis and valuated for the in vitro antioxidant activity. The results obtained in present study suggested that AcMZPS, AlMZPS and their purified fractions could be used as functional foods and natural drugs in preventing the hyperlipidemia and non-alcoholic fatty liver.</description><subject>Animals</subject><subject>Antihyperlipidemic effects</subject><subject>Antioxidant effects</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Body Weight - drug effects</subject><subject>Cytoprotection - drug effects</subject><subject>Fungal Polysaccharides - chemistry</subject><subject>Fungal Polysaccharides - pharmacology</subject><subject>Fungal Polysaccharides - therapeutic use</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hypolipidemic Agents - chemistry</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>Hypolipidemic Agents - therapeutic use</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Mice</subject><subject>Monosaccharides - analysis</subject><subject>Mycelium - chemistry</subject><subject>Pleurotus - chemistry</subject><subject>Pleurotus eryngii var. tuoliensis</subject><subject>Zinc - chemistry</subject><subject>Zinc polysaccharides</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP3TAQRq2qqFwefwF52U3COA_H2RWhPpCQYAFry7EnZa6SOLUT1PDra3ShWxaW5dH5PDOHsQsBuQAhL_c57Tvyo7F5kd65EDlI-MR2QjVtBgDlZ7YDUYlMiRKO2UmM-1SVtVBf2HHRqEY0LezYfDUt5P-SM9PCzeTSWSh72mYMA83kcCTLse_RLpH7no-bxYEMf6HJ8tkPWzTWPpmQyMi7jd8PuAa_rJFj2KbfRPzZhJwvqx8Ip0jxjB31Zoh4_nafsscf3x-uf2W3dz9vrq9uM1tKtWSlNE4WlcTOIVROds41rivaSnTW1qqvoEbsmwJagMoqaaq2rZVSJQjlykKVp-zr4d85-D8rxkWPFNPsg5nQr1ELVRV1m9J1QuUBtcHHGLDXc6DRhE0L0K-29V6_29avtrUQOtlOwYu3Hms3ovsfe9ebgG8HANOmz4RBR5s0WHQUklHtPH3U4x_LepYh</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Xu, Nuo</creator><creator>Ren, Zhenzhen</creator><creator>Zhang, Jianjun</creator><creator>Song, Xinling</creator><creator>Gao, Zheng</creator><creator>Jing, Huijuan</creator><creator>Li, Shangshang</creator><creator>Wang, Shouxian</creator><creator>Jia, Le</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201702</creationdate><title>Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis</title><author>Xu, Nuo ; Ren, Zhenzhen ; Zhang, Jianjun ; Song, Xinling ; Gao, Zheng ; Jing, Huijuan ; Li, Shangshang ; Wang, Shouxian ; Jia, Le</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-36ad6246ebde04d6bdd7db2941bcc58f405eef7209004c86a49958883018d3283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antihyperlipidemic effects</topic><topic>Antioxidant effects</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Body Weight - drug effects</topic><topic>Cytoprotection - drug effects</topic><topic>Fungal Polysaccharides - chemistry</topic><topic>Fungal Polysaccharides - pharmacology</topic><topic>Fungal Polysaccharides - therapeutic use</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hypolipidemic Agents - chemistry</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>Hypolipidemic Agents - therapeutic use</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Mice</topic><topic>Monosaccharides - analysis</topic><topic>Mycelium - chemistry</topic><topic>Pleurotus - chemistry</topic><topic>Pleurotus eryngii var. tuoliensis</topic><topic>Zinc - chemistry</topic><topic>Zinc polysaccharides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Nuo</creatorcontrib><creatorcontrib>Ren, Zhenzhen</creatorcontrib><creatorcontrib>Zhang, Jianjun</creatorcontrib><creatorcontrib>Song, Xinling</creatorcontrib><creatorcontrib>Gao, Zheng</creatorcontrib><creatorcontrib>Jing, Huijuan</creatorcontrib><creatorcontrib>Li, Shangshang</creatorcontrib><creatorcontrib>Wang, Shouxian</creatorcontrib><creatorcontrib>Jia, Le</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Nuo</au><au>Ren, Zhenzhen</au><au>Zhang, Jianjun</au><au>Song, Xinling</au><au>Gao, Zheng</au><au>Jing, Huijuan</au><au>Li, Shangshang</au><au>Wang, Shouxian</au><au>Jia, Le</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2017-02</date><risdate>2017</risdate><volume>95</volume><spage>204</spage><epage>214</epage><pages>204-214</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>•Two modified polysaccharides (AcMZPS and AlMZPS) were isolated and purified.•Hyperlipidemic mice were established by high-fat-high-cholesterol emulsion.•The antioxidant and anti-hyperlipidemic effects were investigated.•Glucose was determined to the major monosaccharide component of polysaccharides.•Findings proved that AcMZPS and AlMZPS had prevention effects of hyperlipidemia.
The aims of this work were designed to investigate the hepatoprotective and antioxidant effects of acidic- and alkali-extractable mycelia zinc polysaccharides (AcMZPS, AlMZPS) from Pleurotus eryngii var. tuoliensis on high-fat-high-cholesterol emulsion-induced hyperlipidemic mice. The in vivo experiments demonstrated that both AcMZPS and AlMZPS had potential hepatoprotective effects by significantly decreasing the levels of LDL-C, VLDL-C, TC, TG, ALT, AST, ALP, MDA and LPO, and remarkably increasing the HDL-C, SOD, GSH-Px, and CAT in serum lipid/liver homogenate, respectively. In addition, four polysaccharide fractions of AcMZPS-1, AcMZPS-2, AlMZPS-1, and AlMZPS-2, purified from AcMZPS and AlMZPS using DEAE chromatography, respectively, were subjected to monosaccharide composition analysis and valuated for the in vitro antioxidant activity. The results obtained in present study suggested that AcMZPS, AlMZPS and their purified fractions could be used as functional foods and natural drugs in preventing the hyperlipidemia and non-alcoholic fatty liver.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27871790</pmid><doi>10.1016/j.ijbiomac.2016.11.060</doi><tpages>11</tpages></addata></record> |
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subjects | Animals Antihyperlipidemic effects Antioxidant effects Antioxidants - chemistry Antioxidants - pharmacology Antioxidants - therapeutic use Body Weight - drug effects Cytoprotection - drug effects Fungal Polysaccharides - chemistry Fungal Polysaccharides - pharmacology Fungal Polysaccharides - therapeutic use Hydrogen-Ion Concentration Hypolipidemic Agents - chemistry Hypolipidemic Agents - pharmacology Hypolipidemic Agents - therapeutic use Liver - drug effects Liver - pathology Mice Monosaccharides - analysis Mycelium - chemistry Pleurotus - chemistry Pleurotus eryngii var. tuoliensis Zinc - chemistry Zinc polysaccharides |
title | Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis |
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