Twenty-six-week repeat-dose toxicity study of a recombinant human granulocyte colony-stimulating factor derivative (Nartograstim) in cynomolgus monkeys

An rhG-CSF derivative, nartograstim (NTG), at dose levels of 0 (saline), 0.1, 1, 10, and 100 microg/kg, was administered subcutaneously to groups of 3 male and 3 female cynomolgus monkeys once daily for 26 weeks to investigate its toxicity. In Week 4 or later, an increase in leukocyte counts consist...

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