A high-fat diet differentially regulates glutathione phenotypes in the obesity-prone mouse strains DBA/2J, C57BL/6J, and AKR/J

The ubiquitous tripeptide glutathione (GSH) is a critical component of the endogenous antioxidant defense system. Tissue GSH concentrations and redox status (GSH/GSSG) are genetically controlled, but it is unclear whether interactions between genetic background and diet affect GSH homeostasis. The c...

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Veröffentlicht in:	Nutrition research (New York, N.Y.) N.Y.), 2016-12, Vol.36 (12), p.1316-1324
Hauptverfasser:	Norris, Katie M., Okie, Whitney, Kim, Woo Kyun, Adhikari, Roshan, Yoo, Sarah, King, Stephanie, Pazdro, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant antioxidant activity Body Weight Diet, High-Fat - adverse effects dietary fat Dietary Fats - administration & dosage Dietary Fats - adverse effects Down-Regulation energy Female females gene expression Gene-Environment Interaction genetic background Genetics glutamate-cysteine ligase Glutamate-Cysteine Ligase - metabolism Glutathione Glutathione - metabolism Glutathione Disulfide - metabolism glutathione peroxidase Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism glutathione-disulfide reductase GSH/GSSG High-fat diet Homeostasis Kidney - metabolism kidneys liver Liver - metabolism mice Mice, Inbred AKR Mice, Inbred C57BL Mice, Inbred DBA Mice, Obese Obesity Obesity - etiology Obesity - genetics Obesity - metabolism Phenotype Random Allocation regression analysis Reverse Transcriptase Polymerase Chain Reaction Up-Regulation
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