The contribution of clinical and psychosocial factors to fatigue in 182 patients with inflammatory bowel disease: a cross‐sectional study
Summary Background Fatigue is a frequently reported and predominant symptom experienced by patients with inflammatory bowel disease (IBD) and its impact has been associated with poorer quality of life (QoL). The complex interplay between disease‐related variables and potentially modifiable psychosoc...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2017-02, Vol.45 (3), p.403-416 |
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| creator | Artom, M. Czuber‐Dochan, W. Sturt, J. Murrells, T. Norton, C. |
| description | Summary
Background
Fatigue is a frequently reported and predominant symptom experienced by patients with inflammatory bowel disease (IBD) and its impact has been associated with poorer quality of life (QoL). The complex interplay between disease‐related variables and potentially modifiable psychosocial factors in IBD‐fatigue has yet to be unravelled.
Aim
To evaluate the contribution of clinical, sociodemographic and psychosocial factors to the severity and impact of IBD‐fatigue and QoL.
Method
In a cross‐sectional study, 182 patients with IBD were recruited from three tertiary referral hospitals’ out‐patient clinics in London. Fatigue was assessed utilising the Inflammatory Bowel Disease‐Fatigue Scale (IBD‐F), the Multidimensional Fatigue Inventory (MFI); and QoL by the Inflammatory Bowel Disease Questionnaire (IBDQ). Patients completed self‐report questionnaires evaluating emotional, cognitive and behavioural factors potentially correlated with fatigue. Sociodemographic data were collected. Disease‐related and laboratory data were retrieved from patients’ hospital electronic medical records.
Result
In hierarchical regression models, disease activity was the only clinical factor consistently associated with severity and impact of fatigue and QoL (P = 0.01). More negative fatigue perceptions were significantly associated with greater IBD‐F1 scores (P = 0.01). When controlling for clinical factors (disease activity and anti‐TNF therapy), negative perceptions of fatigue, and all‐or‐nothing and avoidance behaviours explained an additional 41% of the variance in fatigue impact (IBD‐F2).
Conclusions
Apart from disease activity, emotional and behavioural factors and patients’ negative fatigue perceptions may be key factors to be addressed. Further exploration of these factors in longitudinal and intervention studies may help to develop effective models of fatigue management.
Linked ContentThis article is linked to Gracie, Ford and Artom et al papers. To view these articles visit https://doi.org/10.1111/apt.13922 and https://doi.org/10.1111/apt.13935. |
| doi_str_mv | 10.1111/apt.13870 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1842548824</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1842548824</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3880-84d7c8061ef80a03a272f5306867fe7bdcfc4087887ee7bf0417512cc76b00e83</originalsourceid><addsrcrecordid>eNp1kcFu1DAQhi0EokvhwAsgS1zoIe3YSexZblVFAakSHJZz5Dhj1lUSh9jRKjfuXHhGngS3Wzgg4Ys9o0_fjPUz9lLAucjnwkzpXJSo4RHbiFLVhYRSPWYbkGpbSBTlCXsW4y0AKA3yKTuRGhVKUW_Yj92euA1jmn27JB9GHhy3vR-9NT03Y8enuNp9iMH63HDGpjBHnkJ-Jv91Ie5HLlDyKZc0psgPPu1z0_VmGEyGV96GA_W885FMpLfccDuHGH99_xnJ3o3M3piWbn3OnjjTR3rxcJ-yL9fvdlcfiptP7z9eXd4UtkSEAqtOWwQlyCEYKI3U0tUlKFTakW4762wFqBE15dJBJXQtpLVatQCE5Sl7c_ROc_i2UEzN4KOlvjcjhSU2AitZV4iyyujrf9DbsMx540xtpawquYVtps6O1P3HZnLNNPvBzGsjoLlLqMkJNfcJZfbVg3FpB-r-kn8iycDFETj4ntb_m5rLz7uj8jfstZyB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1922442909</pqid></control><display><type>article</type><title>The contribution of clinical and psychosocial factors to fatigue in 182 patients with inflammatory bowel disease: a cross‐sectional study</title><source>MEDLINE</source><source>Wiley Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><creator>Artom, M. ; Czuber‐Dochan, W. ; Sturt, J. ; Murrells, T. ; Norton, C.</creator><creatorcontrib>Artom, M. ; Czuber‐Dochan, W. ; Sturt, J. ; Murrells, T. ; Norton, C.</creatorcontrib><description>Summary
Background
Fatigue is a frequently reported and predominant symptom experienced by patients with inflammatory bowel disease (IBD) and its impact has been associated with poorer quality of life (QoL). The complex interplay between disease‐related variables and potentially modifiable psychosocial factors in IBD‐fatigue has yet to be unravelled.
Aim
To evaluate the contribution of clinical, sociodemographic and psychosocial factors to the severity and impact of IBD‐fatigue and QoL.
Method
In a cross‐sectional study, 182 patients with IBD were recruited from three tertiary referral hospitals’ out‐patient clinics in London. Fatigue was assessed utilising the Inflammatory Bowel Disease‐Fatigue Scale (IBD‐F), the Multidimensional Fatigue Inventory (MFI); and QoL by the Inflammatory Bowel Disease Questionnaire (IBDQ). Patients completed self‐report questionnaires evaluating emotional, cognitive and behavioural factors potentially correlated with fatigue. Sociodemographic data were collected. Disease‐related and laboratory data were retrieved from patients’ hospital electronic medical records.
Result
In hierarchical regression models, disease activity was the only clinical factor consistently associated with severity and impact of fatigue and QoL (P = 0.01). More negative fatigue perceptions were significantly associated with greater IBD‐F1 scores (P = 0.01). When controlling for clinical factors (disease activity and anti‐TNF therapy), negative perceptions of fatigue, and all‐or‐nothing and avoidance behaviours explained an additional 41% of the variance in fatigue impact (IBD‐F2).
Conclusions
Apart from disease activity, emotional and behavioural factors and patients’ negative fatigue perceptions may be key factors to be addressed. Further exploration of these factors in longitudinal and intervention studies may help to develop effective models of fatigue management.
Linked ContentThis article is linked to Gracie, Ford and Artom et al papers. To view these articles visit https://doi.org/10.1111/apt.13922 and https://doi.org/10.1111/apt.13935.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/apt.13870</identifier><identifier>PMID: 27868215</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Avoidance ; Avoidance behavior ; Cognitive ability ; Colon ; Complex variables ; Cross-Sectional Studies ; Electronic medical records ; Emotional behavior ; Fatigue ; Fatigue - diagnosis ; Fatigue - epidemiology ; Fatigue - psychology ; Female ; Humans ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - complications ; Inflammatory Bowel Diseases - epidemiology ; Inflammatory Bowel Diseases - psychology ; Intestine ; Male ; Middle Aged ; Outpatients - statistics & numerical data ; Quality of Life ; Regression analysis ; Risk Factors ; Sociodemographics ; Socioeconomic Factors ; Surveys and Questionnaires ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - blood ; Young Adult</subject><ispartof>Alimentary pharmacology & therapeutics, 2017-02, Vol.45 (3), p.403-416</ispartof><rights>2016 John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3880-84d7c8061ef80a03a272f5306867fe7bdcfc4087887ee7bf0417512cc76b00e83</citedby><cites>FETCH-LOGICAL-c3880-84d7c8061ef80a03a272f5306867fe7bdcfc4087887ee7bf0417512cc76b00e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapt.13870$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapt.13870$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27868215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Artom, M.</creatorcontrib><creatorcontrib>Czuber‐Dochan, W.</creatorcontrib><creatorcontrib>Sturt, J.</creatorcontrib><creatorcontrib>Murrells, T.</creatorcontrib><creatorcontrib>Norton, C.</creatorcontrib><title>The contribution of clinical and psychosocial factors to fatigue in 182 patients with inflammatory bowel disease: a cross‐sectional study</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
Fatigue is a frequently reported and predominant symptom experienced by patients with inflammatory bowel disease (IBD) and its impact has been associated with poorer quality of life (QoL). The complex interplay between disease‐related variables and potentially modifiable psychosocial factors in IBD‐fatigue has yet to be unravelled.
Aim
To evaluate the contribution of clinical, sociodemographic and psychosocial factors to the severity and impact of IBD‐fatigue and QoL.
Method
In a cross‐sectional study, 182 patients with IBD were recruited from three tertiary referral hospitals’ out‐patient clinics in London. Fatigue was assessed utilising the Inflammatory Bowel Disease‐Fatigue Scale (IBD‐F), the Multidimensional Fatigue Inventory (MFI); and QoL by the Inflammatory Bowel Disease Questionnaire (IBDQ). Patients completed self‐report questionnaires evaluating emotional, cognitive and behavioural factors potentially correlated with fatigue. Sociodemographic data were collected. Disease‐related and laboratory data were retrieved from patients’ hospital electronic medical records.
Result
In hierarchical regression models, disease activity was the only clinical factor consistently associated with severity and impact of fatigue and QoL (P = 0.01). More negative fatigue perceptions were significantly associated with greater IBD‐F1 scores (P = 0.01). When controlling for clinical factors (disease activity and anti‐TNF therapy), negative perceptions of fatigue, and all‐or‐nothing and avoidance behaviours explained an additional 41% of the variance in fatigue impact (IBD‐F2).
Conclusions
Apart from disease activity, emotional and behavioural factors and patients’ negative fatigue perceptions may be key factors to be addressed. Further exploration of these factors in longitudinal and intervention studies may help to develop effective models of fatigue management.
Linked ContentThis article is linked to Gracie, Ford and Artom et al papers. To view these articles visit https://doi.org/10.1111/apt.13922 and https://doi.org/10.1111/apt.13935.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Avoidance</subject><subject>Avoidance behavior</subject><subject>Cognitive ability</subject><subject>Colon</subject><subject>Complex variables</subject><subject>Cross-Sectional Studies</subject><subject>Electronic medical records</subject><subject>Emotional behavior</subject><subject>Fatigue</subject><subject>Fatigue - diagnosis</subject><subject>Fatigue - epidemiology</subject><subject>Fatigue - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Inflammatory Bowel Diseases - epidemiology</subject><subject>Inflammatory Bowel Diseases - psychology</subject><subject>Intestine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Outpatients - statistics & numerical data</subject><subject>Quality of Life</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Sociodemographics</subject><subject>Socioeconomic Factors</subject><subject>Surveys and Questionnaires</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Young Adult</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhi0EokvhwAsgS1zoIe3YSexZblVFAakSHJZz5Dhj1lUSh9jRKjfuXHhGngS3Wzgg4Ys9o0_fjPUz9lLAucjnwkzpXJSo4RHbiFLVhYRSPWYbkGpbSBTlCXsW4y0AKA3yKTuRGhVKUW_Yj92euA1jmn27JB9GHhy3vR-9NT03Y8enuNp9iMH63HDGpjBHnkJ-Jv91Ie5HLlDyKZc0psgPPu1z0_VmGEyGV96GA_W885FMpLfccDuHGH99_xnJ3o3M3piWbn3OnjjTR3rxcJ-yL9fvdlcfiptP7z9eXd4UtkSEAqtOWwQlyCEYKI3U0tUlKFTakW4762wFqBE15dJBJXQtpLVatQCE5Sl7c_ROc_i2UEzN4KOlvjcjhSU2AitZV4iyyujrf9DbsMx540xtpawquYVtps6O1P3HZnLNNPvBzGsjoLlLqMkJNfcJZfbVg3FpB-r-kn8iycDFETj4ntb_m5rLz7uj8jfstZyB</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Artom, M.</creator><creator>Czuber‐Dochan, W.</creator><creator>Sturt, J.</creator><creator>Murrells, T.</creator><creator>Norton, C.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201702</creationdate><title>The contribution of clinical and psychosocial factors to fatigue in 182 patients with inflammatory bowel disease: a cross‐sectional study</title><author>Artom, M. ; Czuber‐Dochan, W. ; Sturt, J. ; Murrells, T. ; Norton, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3880-84d7c8061ef80a03a272f5306867fe7bdcfc4087887ee7bf0417512cc76b00e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Avoidance</topic><topic>Avoidance behavior</topic><topic>Cognitive ability</topic><topic>Colon</topic><topic>Complex variables</topic><topic>Cross-Sectional Studies</topic><topic>Electronic medical records</topic><topic>Emotional behavior</topic><topic>Fatigue</topic><topic>Fatigue - diagnosis</topic><topic>Fatigue - epidemiology</topic><topic>Fatigue - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Inflammatory Bowel Diseases - complications</topic><topic>Inflammatory Bowel Diseases - epidemiology</topic><topic>Inflammatory Bowel Diseases - psychology</topic><topic>Intestine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Outpatients - statistics & numerical data</topic><topic>Quality of Life</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><topic>Sociodemographics</topic><topic>Socioeconomic Factors</topic><topic>Surveys and Questionnaires</topic><topic>Tumor necrosis factor</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Artom, M.</creatorcontrib><creatorcontrib>Czuber‐Dochan, W.</creatorcontrib><creatorcontrib>Sturt, J.</creatorcontrib><creatorcontrib>Murrells, T.</creatorcontrib><creatorcontrib>Norton, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Artom, M.</au><au>Czuber‐Dochan, W.</au><au>Sturt, J.</au><au>Murrells, T.</au><au>Norton, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The contribution of clinical and psychosocial factors to fatigue in 182 patients with inflammatory bowel disease: a cross‐sectional study</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2017-02</date><risdate>2017</risdate><volume>45</volume><issue>3</issue><spage>403</spage><epage>416</epage><pages>403-416</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background
Fatigue is a frequently reported and predominant symptom experienced by patients with inflammatory bowel disease (IBD) and its impact has been associated with poorer quality of life (QoL). The complex interplay between disease‐related variables and potentially modifiable psychosocial factors in IBD‐fatigue has yet to be unravelled.
Aim
To evaluate the contribution of clinical, sociodemographic and psychosocial factors to the severity and impact of IBD‐fatigue and QoL.
Method
In a cross‐sectional study, 182 patients with IBD were recruited from three tertiary referral hospitals’ out‐patient clinics in London. Fatigue was assessed utilising the Inflammatory Bowel Disease‐Fatigue Scale (IBD‐F), the Multidimensional Fatigue Inventory (MFI); and QoL by the Inflammatory Bowel Disease Questionnaire (IBDQ). Patients completed self‐report questionnaires evaluating emotional, cognitive and behavioural factors potentially correlated with fatigue. Sociodemographic data were collected. Disease‐related and laboratory data were retrieved from patients’ hospital electronic medical records.
Result
In hierarchical regression models, disease activity was the only clinical factor consistently associated with severity and impact of fatigue and QoL (P = 0.01). More negative fatigue perceptions were significantly associated with greater IBD‐F1 scores (P = 0.01). When controlling for clinical factors (disease activity and anti‐TNF therapy), negative perceptions of fatigue, and all‐or‐nothing and avoidance behaviours explained an additional 41% of the variance in fatigue impact (IBD‐F2).
Conclusions
Apart from disease activity, emotional and behavioural factors and patients’ negative fatigue perceptions may be key factors to be addressed. Further exploration of these factors in longitudinal and intervention studies may help to develop effective models of fatigue management.
Linked ContentThis article is linked to Gracie, Ford and Artom et al papers. To view these articles visit https://doi.org/10.1111/apt.13922 and https://doi.org/10.1111/apt.13935.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27868215</pmid><doi>10.1111/apt.13870</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Journals; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Adult Aged Aged, 80 and over Avoidance Avoidance behavior Cognitive ability Colon Complex variables Cross-Sectional Studies Electronic medical records Emotional behavior Fatigue Fatigue - diagnosis Fatigue - epidemiology Fatigue - psychology Female Humans Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - epidemiology Inflammatory Bowel Diseases - psychology Intestine Male Middle Aged Outpatients - statistics & numerical data Quality of Life Regression analysis Risk Factors Sociodemographics Socioeconomic Factors Surveys and Questionnaires Tumor necrosis factor Tumor Necrosis Factor-alpha - blood Young Adult |
| title | The contribution of clinical and psychosocial factors to fatigue in 182 patients with inflammatory bowel disease: a cross‐sectional study |
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