Snake venom l-amino acid oxidases
l-amino acid oxidases are widely found in snake venoms and are thought to contribute to the toxicity upon envenomation. The mechanism of these toxic effects and whether they result from the enzymatic activity are still uncertain although many papers describing the biological and pharmacological effe...
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| Veröffentlicht in: | Toxicon 2002-06, Vol.40 (6), p.659-665 |
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| container_title | Toxicon |
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| creator | Du, Xiao-Yan Clemetson, Kenneth J. |
| description | l-amino acid oxidases are widely found in snake venoms and are thought to contribute to the toxicity upon envenomation. The mechanism of these toxic effects and whether they result from the enzymatic activity are still uncertain although many papers describing the biological and pharmacological effects of
l-amino acid oxidases have appeared recently, which provide more information about their action on platelets, induction of apoptosis, haemorrhagic effects, and cytotoxicity. This review summarizes the physiochemical properties, structural characteristics and various biological functions of snake venom
l-amino acid oxidases (SV-LAAOs). In addition, the putative mechanisms of SV-LAAO-induced platelet aggregation and apoptosis of cells are discussed in more detail. |
| doi_str_mv | 10.1016/S0041-0101(02)00102-2 |
| format | Article |
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l-amino acid oxidases have appeared recently, which provide more information about their action on platelets, induction of apoptosis, haemorrhagic effects, and cytotoxicity. This review summarizes the physiochemical properties, structural characteristics and various biological functions of snake venom
l-amino acid oxidases (SV-LAAOs). In addition, the putative mechanisms of SV-LAAO-induced platelet aggregation and apoptosis of cells are discussed in more detail.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/S0041-0101(02)00102-2</identifier><identifier>PMID: 12175601</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Amino Acid Oxidoreductases - chemistry ; Amino Acid Oxidoreductases - metabolism ; Amino Acid Sequence ; Animal poisons toxicology. Antivenoms ; Animals ; Apoptosis ; Biological and medical sciences ; Hydrogen peroxide ; L-Amino Acid Oxidase ; Medical sciences ; Models, Chemical ; Molecular Sequence Data ; Platelet aggregation ; Sequence Homology, Amino Acid ; Snake venom ; Snake Venoms - enzymology ; Snakes - physiology ; Species Specificity ; Toxicology</subject><ispartof>Toxicon, 2002-06, Vol.40 (6), p.659-665</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><rights>Copright 2002 Elsevier Science Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-ef66483ed4c1b0bd39fecbf8af31ebc8491ad9577f93f198193a608d7efd2a0d3</citedby><cites>FETCH-LOGICAL-c474t-ef66483ed4c1b0bd39fecbf8af31ebc8491ad9577f93f198193a608d7efd2a0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0041-0101(02)00102-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,778,782,790,3539,27911,27913,27914,45984</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14185759$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12175601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Du, Xiao-Yan</creatorcontrib><creatorcontrib>Clemetson, Kenneth J.</creatorcontrib><title>Snake venom l-amino acid oxidases</title><title>Toxicon</title><addtitle>Toxicon</addtitle><description>l-amino acid oxidases are widely found in snake venoms and are thought to contribute to the toxicity upon envenomation. The mechanism of these toxic effects and whether they result from the enzymatic activity are still uncertain although many papers describing the biological and pharmacological effects of
l-amino acid oxidases have appeared recently, which provide more information about their action on platelets, induction of apoptosis, haemorrhagic effects, and cytotoxicity. This review summarizes the physiochemical properties, structural characteristics and various biological functions of snake venom
l-amino acid oxidases (SV-LAAOs). In addition, the putative mechanisms of SV-LAAO-induced platelet aggregation and apoptosis of cells are discussed in more detail.</description><subject>Amino Acid Oxidoreductases - chemistry</subject><subject>Amino Acid Oxidoreductases - metabolism</subject><subject>Amino Acid Sequence</subject><subject>Animal poisons toxicology. Antivenoms</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Hydrogen peroxide</subject><subject>L-Amino Acid Oxidase</subject><subject>Medical sciences</subject><subject>Models, Chemical</subject><subject>Molecular Sequence Data</subject><subject>Platelet aggregation</subject><subject>Sequence Homology, Amino Acid</subject><subject>Snake venom</subject><subject>Snake Venoms - enzymology</subject><subject>Snakes - physiology</subject><subject>Species Specificity</subject><subject>Toxicology</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLlOAzEQhi0EIiHwCKBQgKBYmFnvYVcIRVxSJIpAbXntsWTYI6yTCN6eTbIiJdVM8f1zfIydItwgYHY7A0gwgq6_gvgauiaO4j02RJHLiGMK-2z4hwzYUQgfAMCFzA7ZAGPM0wxwyM5ntf6k8YrqphqXka583Yy18XbcfHurA4VjduB0GeikryP2_vjwNnmOpq9PL5P7aWSSPFlE5LIsEZxsYrCAwnLpyBROaMeRCiMSidrKNM-d5A6lQMl1BsLm5GyswfIRu9zOnbfN15LCQlU-GCpLXVOzDApFEqdcZB2YbkHTNiG05NS89ZVufxSCWrtRGzdq_biCWG3cqLjLnfULlkVFdpfqZXTARQ_oYHTpWl0bH3ZcgiLNU9lxd1uOOh0rT60KxlNtyPqWzELZxv9zyi9fE36O</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Du, Xiao-Yan</creator><creator>Clemetson, Kenneth J.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20020601</creationdate><title>Snake venom l-amino acid oxidases</title><author>Du, Xiao-Yan ; Clemetson, Kenneth J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-ef66483ed4c1b0bd39fecbf8af31ebc8491ad9577f93f198193a608d7efd2a0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Amino Acid Oxidoreductases - chemistry</topic><topic>Amino Acid Oxidoreductases - metabolism</topic><topic>Amino Acid Sequence</topic><topic>Animal poisons toxicology. Antivenoms</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Hydrogen peroxide</topic><topic>L-Amino Acid Oxidase</topic><topic>Medical sciences</topic><topic>Models, Chemical</topic><topic>Molecular Sequence Data</topic><topic>Platelet aggregation</topic><topic>Sequence Homology, Amino Acid</topic><topic>Snake venom</topic><topic>Snake Venoms - enzymology</topic><topic>Snakes - physiology</topic><topic>Species Specificity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Xiao-Yan</creatorcontrib><creatorcontrib>Clemetson, Kenneth J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicon</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Xiao-Yan</au><au>Clemetson, Kenneth J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Snake venom l-amino acid oxidases</atitle><jtitle>Toxicon</jtitle><addtitle>Toxicon</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>40</volume><issue>6</issue><spage>659</spage><epage>665</epage><pages>659-665</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>l-amino acid oxidases are widely found in snake venoms and are thought to contribute to the toxicity upon envenomation. The mechanism of these toxic effects and whether they result from the enzymatic activity are still uncertain although many papers describing the biological and pharmacological effects of
l-amino acid oxidases have appeared recently, which provide more information about their action on platelets, induction of apoptosis, haemorrhagic effects, and cytotoxicity. This review summarizes the physiochemical properties, structural characteristics and various biological functions of snake venom
l-amino acid oxidases (SV-LAAOs). In addition, the putative mechanisms of SV-LAAO-induced platelet aggregation and apoptosis of cells are discussed in more detail.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12175601</pmid><doi>10.1016/S0041-0101(02)00102-2</doi><tpages>7</tpages></addata></record> |
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| ispartof | Toxicon, 2002-06, Vol.40 (6), p.659-665 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Amino Acid Oxidoreductases - chemistry Amino Acid Oxidoreductases - metabolism Amino Acid Sequence Animal poisons toxicology. Antivenoms Animals Apoptosis Biological and medical sciences Hydrogen peroxide L-Amino Acid Oxidase Medical sciences Models, Chemical Molecular Sequence Data Platelet aggregation Sequence Homology, Amino Acid Snake venom Snake Venoms - enzymology Snakes - physiology Species Specificity Toxicology |
| title | Snake venom l-amino acid oxidases |
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