Differentiating the Causes of Spontaneous Rib Fracture After Breast Cancer
Abstract Spontaneous rib fracture after treatment for primary breast cancer is not uncommon. Although metastatic disease accounts for about 30% of spontaneous rib fractures and should constitute the first line of diagnostic investigation, other possible contributors include primary osteoporosis or s...
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| Veröffentlicht in: | Clinical breast cancer 2016-12, Vol.16 (6), p.431-436 |
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| creator | Harris, Susan R |
| description | Abstract Spontaneous rib fracture after treatment for primary breast cancer is not uncommon. Although metastatic disease accounts for about 30% of spontaneous rib fractures and should constitute the first line of diagnostic investigation, other possible contributors include primary osteoporosis or secondary osteoporosis resulting from cancer treatments. Chemotherapy-induced menopause, aromatase inhibitors, radiation therapy, and long-term bisphosphonate use can all contribute to bone fragility, including spontaneous rib fractures in the latter 3. Drawing on recent breast cancer practice guidelines as well as population-based studies of fracture risk for women with a history of breast cancer and systematic reviews, this Perspective will provide an update on recent developments in understanding how to differentiate the possible reasons for non-traumatic rib fracture in women treated for breast cancer. In addition to describing the various possible causes of spontaneous rib fracture, the recommended medical and imaging procedures for differentiating among the potential causes will be presented. |
| doi_str_mv | 10.1016/j.clbc.2016.07.001 |
| format | Article |
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Although metastatic disease accounts for about 30% of spontaneous rib fractures and should constitute the first line of diagnostic investigation, other possible contributors include primary osteoporosis or secondary osteoporosis resulting from cancer treatments. Chemotherapy-induced menopause, aromatase inhibitors, radiation therapy, and long-term bisphosphonate use can all contribute to bone fragility, including spontaneous rib fractures in the latter 3. Drawing on recent breast cancer practice guidelines as well as population-based studies of fracture risk for women with a history of breast cancer and systematic reviews, this Perspective will provide an update on recent developments in understanding how to differentiate the possible reasons for non-traumatic rib fracture in women treated for breast cancer. In addition to describing the various possible causes of spontaneous rib fracture, the recommended medical and imaging procedures for differentiating among the potential causes will be presented.</description><identifier>ISSN: 1526-8209</identifier><identifier>EISSN: 1938-0666</identifier><identifier>DOI: 10.1016/j.clbc.2016.07.001</identifier><identifier>PMID: 27498118</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age Factors ; Aromatase inhibitors ; Aromatase Inhibitors - adverse effects ; Aromatase Inhibitors - therapeutic use ; Biopsy ; Bone Density - drug effects ; Bone Density - radiation effects ; Bone Density Conservation Agents - adverse effects ; Bone Density Conservation Agents - therapeutic use ; Bone fragility ; Bone Neoplasms - complications ; Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - pathology ; Bone Neoplasms - secondary ; Breast Neoplasms - pathology ; Breast Neoplasms - therapy ; Differential diagnosis ; Diphosphonates - adverse effects ; Diphosphonates - therapeutic use ; Female ; Fractures, Spontaneous - diagnostic imaging ; Fractures, Spontaneous - etiology ; Hematology, Oncology and Palliative Medicine ; Humans ; Menopause, Premature - drug effects ; Metastasis ; Obstetrics and Gynecology ; Osteoporosis - chemically induced ; Osteoporosis - complications ; Osteoporosis - diagnostic imaging ; Osteoporosis, Postmenopausal - complications ; Osteoporosis, Postmenopausal - diagnostic imaging ; Primary Ovarian Insufficiency - chemically induced ; Primary Ovarian Insufficiency - complications ; Radiation fibrosis ; Radiotherapy - adverse effects ; Rib Fractures - diagnostic imaging ; Rib Fractures - etiology ; Tomography, X-Ray Computed</subject><ispartof>Clinical breast cancer, 2016-12, Vol.16 (6), p.431-436</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-3a2a594d2624dcbd4d29cabb77688b93f17967ae880cb772b990b3fb3e2308bf3</citedby><cites>FETCH-LOGICAL-c411t-3a2a594d2624dcbd4d29cabb77688b93f17967ae880cb772b990b3fb3e2308bf3</cites><orcidid>0000-0003-2679-6548</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clbc.2016.07.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27498118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harris, Susan R</creatorcontrib><title>Differentiating the Causes of Spontaneous Rib Fracture After Breast Cancer</title><title>Clinical breast cancer</title><addtitle>Clin Breast Cancer</addtitle><description>Abstract Spontaneous rib fracture after treatment for primary breast cancer is not uncommon. Although metastatic disease accounts for about 30% of spontaneous rib fractures and should constitute the first line of diagnostic investigation, other possible contributors include primary osteoporosis or secondary osteoporosis resulting from cancer treatments. Chemotherapy-induced menopause, aromatase inhibitors, radiation therapy, and long-term bisphosphonate use can all contribute to bone fragility, including spontaneous rib fractures in the latter 3. Drawing on recent breast cancer practice guidelines as well as population-based studies of fracture risk for women with a history of breast cancer and systematic reviews, this Perspective will provide an update on recent developments in understanding how to differentiate the possible reasons for non-traumatic rib fracture in women treated for breast cancer. In addition to describing the various possible causes of spontaneous rib fracture, the recommended medical and imaging procedures for differentiating among the potential causes will be presented.</description><subject>Age Factors</subject><subject>Aromatase inhibitors</subject><subject>Aromatase Inhibitors - adverse effects</subject><subject>Aromatase Inhibitors - therapeutic use</subject><subject>Biopsy</subject><subject>Bone Density - drug effects</subject><subject>Bone Density - radiation effects</subject><subject>Bone Density Conservation Agents - adverse effects</subject><subject>Bone Density Conservation Agents - therapeutic use</subject><subject>Bone fragility</subject><subject>Bone Neoplasms - complications</subject><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - pathology</subject><subject>Bone Neoplasms - secondary</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Differential diagnosis</subject><subject>Diphosphonates - adverse effects</subject><subject>Diphosphonates - therapeutic use</subject><subject>Female</subject><subject>Fractures, Spontaneous - diagnostic imaging</subject><subject>Fractures, Spontaneous - etiology</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Menopause, Premature - drug effects</subject><subject>Metastasis</subject><subject>Obstetrics and Gynecology</subject><subject>Osteoporosis - chemically induced</subject><subject>Osteoporosis - complications</subject><subject>Osteoporosis - diagnostic imaging</subject><subject>Osteoporosis, Postmenopausal - complications</subject><subject>Osteoporosis, Postmenopausal - diagnostic imaging</subject><subject>Primary Ovarian Insufficiency - chemically induced</subject><subject>Primary Ovarian Insufficiency - complications</subject><subject>Radiation fibrosis</subject><subject>Radiotherapy - adverse effects</subject><subject>Rib Fractures - diagnostic imaging</subject><subject>Rib Fractures - etiology</subject><subject>Tomography, X-Ray Computed</subject><issn>1526-8209</issn><issn>1938-0666</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9rFTEUxYNYbG39Ai7KLN3MmJvMyyQgQn21aikU-mcdksyN5jlv5plkCv32zfBaFy5chBzCOYeb3yXkPdAGKIiPm8YN1jWs6IZ2DaXwihyB4rKmQojXRa-YqCWj6pC8TWlDKRMc6BtyyLpWSQB5RC7Pg_cYcczB5DD-rPIvrNZmTpiqyVe3u2nMZsRpTtVNsNVFNC7PEasznzFWXyKalIt_dBhPyIE3Q8J3z_cxub_4erf-Xl9df_uxPruqXQuQa26YWam2Z4K1vbN9UcoZa7tOSGkV99Ap0RmUkrryyKxS1HJvOTJOpfX8mHzY9-7i9GfGlPU2JIfDsJ9Tg2zZipcDxcr2VhenlCJ6vYtha-KjBqoXhnqjF4Z6YahppwvDEjp97p_tFvu_kRdoxfBpb8Dyy4eAUScXsCDoQ0SXdT-F__d__ifuhjAGZ4bf-IhpM81xLPw06MQ01bfLFpclguAUCiT-BCk7lps</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Harris, Susan R</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2679-6548</orcidid></search><sort><creationdate>20161201</creationdate><title>Differentiating the Causes of Spontaneous Rib Fracture After Breast Cancer</title><author>Harris, Susan R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-3a2a594d2624dcbd4d29cabb77688b93f17967ae880cb772b990b3fb3e2308bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age Factors</topic><topic>Aromatase inhibitors</topic><topic>Aromatase Inhibitors - adverse effects</topic><topic>Aromatase Inhibitors - therapeutic use</topic><topic>Biopsy</topic><topic>Bone Density - drug effects</topic><topic>Bone Density - radiation effects</topic><topic>Bone Density Conservation Agents - adverse effects</topic><topic>Bone Density Conservation Agents - therapeutic use</topic><topic>Bone fragility</topic><topic>Bone Neoplasms - complications</topic><topic>Bone Neoplasms - diagnostic imaging</topic><topic>Bone Neoplasms - pathology</topic><topic>Bone Neoplasms - secondary</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - therapy</topic><topic>Differential diagnosis</topic><topic>Diphosphonates - adverse effects</topic><topic>Diphosphonates - therapeutic use</topic><topic>Female</topic><topic>Fractures, Spontaneous - diagnostic imaging</topic><topic>Fractures, Spontaneous - etiology</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Menopause, Premature - drug effects</topic><topic>Metastasis</topic><topic>Obstetrics and Gynecology</topic><topic>Osteoporosis - chemically induced</topic><topic>Osteoporosis - complications</topic><topic>Osteoporosis - diagnostic imaging</topic><topic>Osteoporosis, Postmenopausal - complications</topic><topic>Osteoporosis, Postmenopausal - diagnostic imaging</topic><topic>Primary Ovarian Insufficiency - chemically induced</topic><topic>Primary Ovarian Insufficiency - complications</topic><topic>Radiation fibrosis</topic><topic>Radiotherapy - adverse effects</topic><topic>Rib Fractures - diagnostic imaging</topic><topic>Rib Fractures - etiology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harris, Susan R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical breast cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harris, Susan R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differentiating the Causes of Spontaneous Rib Fracture After Breast Cancer</atitle><jtitle>Clinical breast cancer</jtitle><addtitle>Clin Breast Cancer</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>16</volume><issue>6</issue><spage>431</spage><epage>436</epage><pages>431-436</pages><issn>1526-8209</issn><eissn>1938-0666</eissn><abstract>Abstract Spontaneous rib fracture after treatment for primary breast cancer is not uncommon. Although metastatic disease accounts for about 30% of spontaneous rib fractures and should constitute the first line of diagnostic investigation, other possible contributors include primary osteoporosis or secondary osteoporosis resulting from cancer treatments. Chemotherapy-induced menopause, aromatase inhibitors, radiation therapy, and long-term bisphosphonate use can all contribute to bone fragility, including spontaneous rib fractures in the latter 3. Drawing on recent breast cancer practice guidelines as well as population-based studies of fracture risk for women with a history of breast cancer and systematic reviews, this Perspective will provide an update on recent developments in understanding how to differentiate the possible reasons for non-traumatic rib fracture in women treated for breast cancer. In addition to describing the various possible causes of spontaneous rib fracture, the recommended medical and imaging procedures for differentiating among the potential causes will be presented.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27498118</pmid><doi>10.1016/j.clbc.2016.07.001</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2679-6548</orcidid></addata></record> |
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| subjects | Age Factors Aromatase inhibitors Aromatase Inhibitors - adverse effects Aromatase Inhibitors - therapeutic use Biopsy Bone Density - drug effects Bone Density - radiation effects Bone Density Conservation Agents - adverse effects Bone Density Conservation Agents - therapeutic use Bone fragility Bone Neoplasms - complications Bone Neoplasms - diagnostic imaging Bone Neoplasms - pathology Bone Neoplasms - secondary Breast Neoplasms - pathology Breast Neoplasms - therapy Differential diagnosis Diphosphonates - adverse effects Diphosphonates - therapeutic use Female Fractures, Spontaneous - diagnostic imaging Fractures, Spontaneous - etiology Hematology, Oncology and Palliative Medicine Humans Menopause, Premature - drug effects Metastasis Obstetrics and Gynecology Osteoporosis - chemically induced Osteoporosis - complications Osteoporosis - diagnostic imaging Osteoporosis, Postmenopausal - complications Osteoporosis, Postmenopausal - diagnostic imaging Primary Ovarian Insufficiency - chemically induced Primary Ovarian Insufficiency - complications Radiation fibrosis Radiotherapy - adverse effects Rib Fractures - diagnostic imaging Rib Fractures - etiology Tomography, X-Ray Computed |
| title | Differentiating the Causes of Spontaneous Rib Fracture After Breast Cancer |
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