Abstract 4722: Selective inhibition of DNA methyltransferases and efficacy of novel DNMT inhibitors in leukemia xenografts

Background. DNA methyltransferase (DNMT) 1 plays an important role in tumorigenesis and is responsible for maintenance and propagation of DNA methylation patterns, and DNMT3A and DNMT3B are involved in de novo DNA methylation. 4’-Thio-5-aza-2’-deoxycytidine (5-aza-T-dCyd) and 4’-thio-2’-deoxycytidin...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-07, Vol.76 (14_Supplement), p.4722-4722
Hauptverfasser:	Nguyen, Dat, Hollingshead, Melinda, Rubinstein, Larry, Doroshow, James, Yang, Sherry X.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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